The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular u
The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
대표청구항▼
The invention claimed is: 1. A method, in a subject in need thereof, of delivering an amphetamine, said method comprising administering to said subject L-lysine-d-amphetamine or a salt thereof. 2. A method as defined in claim 1, wherein said subject suffers from attention deficit hyperactivity di
The invention claimed is: 1. A method, in a subject in need thereof, of delivering an amphetamine, said method comprising administering to said subject L-lysine-d-amphetamine or a salt thereof. 2. A method as defined in claim 1, wherein said subject suffers from attention deficit hyperactivity disorder. 3. A method as defined in claim 1, wherein said subject is an adult human. 4. A method as defined in claim 1, wherein said subject is a human who is not an adult. 5. A method as defined in claim 1, wherein said L-lysine-d-amphetamine is in the form of a salt. 6. A method as defined in claim 5, wherein said salt is a mesylate salt. 7. A method as defined in claim 6, wherein said salt is a dimesylate salt. 8. A method as defined in claim 5, wherein said salt is a hydrochloride salt. 9. A method as defined in claim 1, wherein said L-lysine-d-amphetamine or salt thereof is in a dosage form selected from the group consisting of a tablet, capsule, caplet, oral solution, and oral suspension. 10. A method as defined in claim 9, wherein the amount of said L-lysine-d-amphetamine or salt thereof in said dosage form is from about 2.5 to about 500 mg. 11. A method as defined in claim 10, wherein said amount is from about 5 to about 500 mg. 12. A method as defined in claim 11, wherein the amount is from about 10 to about 100 mg. 13. A method as defined in claim 12, wherein said amount is from 25 to 75 mg. 14. A method as defined in claim 13, wherein said amount is 30 mg. 15. A method as defined in claim 13, wherein said amount is 50 mg. 16. A method as defined in claim 13, wherein said amount is 70 mg. 17. A method, in a subject in need thereof, of delivering an amphetamine, said method comprising administering to said subject a composition comprising L-lysine-d-amphetamine or a salt thereof having a covalent bond between an amphetamine moiety and a lysine moiety, and hydrolysing said covalent bond. 18. A method as defined in claim 17, wherein said subject suffers from attention deficit hyperactivity disorder. 19. A method as defined in claim 17, wherein said subject is an adult human. 20. A method as defined in claim 17, wherein said subject is a human who is not an adult. 21. A method as defined in claim 17, wherein said L-lysine-d-amphetamine is in the form of a salt. 22. A method as defined in claim 21, wherein said salt is a mesylate salt. 23. A method as defined in claim 22, wherein said salt is a dimesylate salt. 24. A method as defined in claim 21, wherein said salt is a hydrochloride salt. 25. A method as defined in claim 17, wherein said L-lysine-d-amphetamine or salt thereof is in a dosage form selected from the group consisting of a tablet, capsule, caplet, oral solution, and oral suspension. 26. A method as defined in claim 25, wherein the amount of said L-lysine-d-amphetamine or salt thereof in said dosage form is from about 2.5 to about 500 mg. 27. A method as defined in claim 26, wherein said amount is from about 5 to about 500 mg. 28. A method as defined in claim 27, wherein the amount is from about 10 to about 100 mg. 29. A method as defined in claim 28, wherein said amount is from 25 to 75 mg. 30. A method as defined in claim 29, wherein said amount is 30 mg. 31. A method as defined in claim 29, wherein said amount is 50 mg. 32. A method as defined in claim 29, wherein said amount is 70 mg.
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