A method of treating a mammal to promote wound healing in the mammal in need thereof, comprising orally administering to the mammal an effective amount of a palatable, concentrated protein composition comprising an effective amount of hydrolyzed gelatin and tryptophan, and an ingestible carrier, the
A method of treating a mammal to promote wound healing in the mammal in need thereof, comprising orally administering to the mammal an effective amount of a palatable, concentrated protein composition comprising an effective amount of hydrolyzed gelatin and tryptophan, and an ingestible carrier, the composition comprising the essential amino acids required by the mammal. Palatability is preferably achieved by the use of an effective amount of a sweetener. The method is particularly useful for treating wounds resulting from decubitus ulcers and bariatric surgery.
대표청구항▼
The invention claimed is: 1. A method of treating a mammal, comprising having said mammal orally ingest an effective amount of a concentrated protein composition comprising about 5 to about 75 parts by weight of enzymatically hydrolyzed animal collagen gelatin, about 0.02 to about 2.0 parts by weig
The invention claimed is: 1. A method of treating a mammal, comprising having said mammal orally ingest an effective amount of a concentrated protein composition comprising about 5 to about 75 parts by weight of enzymatically hydrolyzed animal collagen gelatin, about 0.02 to about 2.0 parts by weight of tryptophan, about 0.1 to about 2 parts by weight of a sweetener, and about 5 to about 100 parts by weight of an ingestible carrier, said composition comprising the amino acids alanine, arginine, aspartic acid, cystine, glutamic acid, glycine, hydroxylysine, hydroxyproline, proline, serine, tyrosine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine; said concentrated composition administered in a 1 ounce (30 mL) dosage to promote wound healing of decubitus or pressure ulcers in said mammal in need thereof; wherein said composition comprises the following amino acids, in grams per hundred grams of protein, each value understood to include a range of ±30% by weight: Amino Acid g/100 g Protein L-Alanine 8.60 L-Arginine 7.90 L-Aspartic Acid 5.90 L-Cystine 0.07 L-Glutamic Acid 9.90 Glycine 23.10 L-Histidine 0.73 Hydroxylysine 1.00 L-Hydroxyproline 6.60 L-Isoleucine 1.30 L-Leucine 3.00 L-Lysine 4.30 L-Methionine 0.73 L-Phenylalanine 2.30 L-Proline 15.20 L-Serine 6.60 L-Threonine 2.00 L-Tryptophan 0.40 L-Tyrosine 0.70 L-Valine 2.40. 2. The method of claim 1 wherein said hydrolyzed gelatin is a product resulting from the proteolytic enzymatic hydrolysis of gelatin derived from animal collagen. 3. The method of claim 2 wherein said animal collagen is derived from the skin of one or more animals selected from the group consisting of the pig, bovine, ox, cow, calf, bull, sheep, goat, antelope and buffalo. 4. The method of claim 3 wherein said animal collagen is derived from the skin of pork bellies or calves. 5. The method of claim 2 wherein said hydrolysis is accomplished with a protease selected from the group consisting of animal and bacterial serine protease, plant cysteine protease, animal and fungal aspartic protease, animal and bacterial metallo protease, and mixtures of the aforementioned proteases. 6. The method of claim 5 wherein said protease is an enzyme is selected from the group consisting of bromelain, papain, chymopapain, ficin, pepsin, chymosin and trypsin. 7. The method of claim 5 wherein said protease is papain. 8. The method of claim 1 wherein the composition is in liquid form and wherein the carrier is water in a proportion of about 15 to about 80 parts by weight, said composition additionally comprising, in parts by weight, about 0.3 to about 10 parts of a palatable acid, about 7 to about 25 parts of sorbitol (70 wt.%), about 0.1 to about 3 parts of a preservative, and about 0 to about 0.4 parts of a flavoring agent. 9. The method of claim 1 wherein the composition is administered in addition to the generally accepted standard treatment for treatment of decubitus ulcers, said standard treatment including identifying individuals at high risk for pressure ulcers; frequently changing the position of immobile patients to relieve pressure; using items in contact with the individual to help reduce or relieve pressure; using powdered lubricants, salves or skin creams; ensuring sufficient dietary intake to avoid malnutrition; encouraging daily exercise, including range-of-motion exercises; following good skin care and personal hygiene; debridement and cleansing of wounds; using dressings that maintain a moist environment at the wound/dressing interface; and instituting, where appropriate, systemic antibiotic therapy. 10. The method of claim 1 wherein said sweetener is a natural sweetener, an artificial sweetener or mixtures thereof. 11. The method of claim 10 wherein said artificial sweetener is selected from the group consisting of acesulfame potassium, aspartame, neotame, saccharin, sucralose, alitame, cyclamate and mixtures thereof. 12. The method of claim 10 wherein said natural sweetener is selected from the group consisting of tagatose, trehalose, a dihydrochalcone, clycyrrhizin, stevioside, thaumatin, erythritol, hydrogenated starch hydolysates, isomalt, lactitol, maltitol, mannitol, sorbitol, xylitol and mixtures thereof. 13. The method of claim 11 wherein said artificial sweetener is sucralose. 14. The method of claim 1 wherein the amount of said concentrated protein composition ingested is about 30 mL and is sufficient to provide about 15 grams of protein and from about 64 to about 101 calories. 15. The method of claim 1 wherein about 30 mL of said composition having about 15 grams of protein and about 64 to about 101 calories is ingested by mouth or by gastrointestinal feeding tube twice or three times per day. 16. The method of claim 1 wherein about 30 mL of said composition having about 15 grams of protein and about 64 to about 101 calories is ingested by mouth or by gastrointestinal feeding tube twice or three times per day. 17. The method of claim 1 wherein said mammal is a person.
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