Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/00
A61K-038/16
A61K-038/17
A61K-038/18
A61K-031/7088
A61K-031/7105
A61K-031/711
A61K-031/713
출원번호
UP-0594510
(2006-11-07)
등록번호
US-7687462
(2010-04-23)
발명자
/ 주소
Ting, Kang
Wu, Ben
Soo, Chia
출원인 / 주소
The Regents of the University of California
대리인 / 주소
Squire, Sanders & Dempsey L.L.P.
인용정보
피인용 횟수 :
30인용 특허 :
18
초록
Provided herein is a composition for cartilage formation or regeneration comprising a NELL gene product and a method of treating cartilage-related conditions using such a composition.
대표청구항▼
We claim: 1. A method of increasing cartilage formation or repair comprising: applying a NELL-1 peptide or an expression vector encoding said NELL-1 peptide in an effective amount for cartilage formation or repair in a region where cartilage formation or repair is desired; optionally applying an ag
We claim: 1. A method of increasing cartilage formation or repair comprising: applying a NELL-1 peptide or an expression vector encoding said NELL-1 peptide in an effective amount for cartilage formation or repair in a region where cartilage formation or repair is desired; optionally applying an agent to the region where cartilage formation or repair is desired; and at least inducing hypertrophy of chondroblast in the region where cartilage formation or repair is desired, wherein the NELL-1 peptide comprises the amino acid sequence set forth in SEQ ID NO: 2, 4, or 6 or a fragment of the amino acid sequence of SEQ ID NO: 2, 4, or 6 which has cartilage-forming activity. 2. The method of claim 1, wherein cartilage formation or repair includes bone healing or bone regeneration. 3. The method of claim 1, wherein the agent is selected from chondroprotective agents, anti-pain and/or anti-inflammatory agents, growth factors, cytokines, small molecules, anti-angiogenic factors, and combinations thereof. 4. The method of claim 1, wherein the agent is selected from collagen, bone matrix, ligament matrix, tendon matrix, chondrogenic cells, and osteochondroprogenitor cells. 5. A method of treating or ameliorating a cartilage related condition, comprising applying to a site in a mammalian subject a composition comprising a NELL-1 peptide or an expression vector encoding said NELL-1 peptide in an effective amount for cartilage formation or repair; wherein the NELL-1 peptide comprises the amino acid sequence set forth in SEQ ID NO: 2, 4, or 6 or a fragment of the amino acid sequence of SEQ ID NO: 2, 4, or 6 which has cartilage-forming activity. 6. The method of claim 5, wherein the composition further comprises a second agent selected from the group consisting of chondroprotective agents, anti-pain and/or anti-inflammatory agents, growth factors, cytokines, small molecules, anti-angiogenic factors and combinations thereof. 7. A method of treating or ameliorating a cartilage related condition, comprising applying to a site in a mammalian subject an implant comprising a substrate having a surface, wherein at least a portion of the surface includes a composition that comprises a NELL-1 peptide or an expression vector encoding said NELL-1 peptide in an effective amount for cartilage formation or repair; wherein the NELL-1 peptide comprises the amino acid sequence set forth in SEQ ID NO: 2, 4, or 6 or a fragment of the amino acid sequence of SEQ ID NO: 2, 4, or 6 which has cartilage-forming activity. 8. The method of claim 7, wherein the composition further comprises a second agent selected from the group consisting of chondroprotective agents, anti-pain and/or anti-inflammatory agents, growth factors, cytokines, small molecules, anti-angiogenic factors and combinations thereof.
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