IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0920734
(2004-08-18)
|
등록번호 |
US-7689276
(2010-04-23)
|
발명자
/ 주소 |
|
출원인 / 주소 |
|
인용정보 |
피인용 횟수 :
92 인용 특허 :
82 |
초록
▼
A method for the treatment of obesity or other disorders by electrical activation or inhibition of nerves is disclosed. This activation or inhibition can be accomplished by stimulating a nerve using an electrode. Dynamic stimulation through ramped cycling of electrical stimulation, stimulation frequ
A method for the treatment of obesity or other disorders by electrical activation or inhibition of nerves is disclosed. This activation or inhibition can be accomplished by stimulating a nerve using an electrode. Dynamic stimulation through ramped cycling of electrical stimulation, stimulation frequency alteration, and/or duty cycle variance can produce therapeutic benefits.
대표청구항
▼
What is claimed is: 1. A method of electrically stimulating a splanchnic nerve in a mammal by applying a stimulation pattern to provide weight loss, the method comprising: applying an intermittent electrical signal comprising a frequency, a pulse width and a current to the splanchnic nerve, wherein
What is claimed is: 1. A method of electrically stimulating a splanchnic nerve in a mammal by applying a stimulation pattern to provide weight loss, the method comprising: applying an intermittent electrical signal comprising a frequency, a pulse width and a current to the splanchnic nerve, wherein the intermittent signal comprises a stimulation time period and a no stimulation time period and wherein the stimulation time period comprises a signal on time and a signal off time; changing the intermittent electrical signal frequently enough, and substantially enough to prevent compensation, wherein the changing intermittent electrical signal is configured to achieve a net weight loss over at least 28 days. 2. The method of claim 1, wherein the frequency is increased after one or more signal off times. 3. The method of claim 1, wherein the current is increased after one or more signal off time. 4. The method of claim 1, wherein the stimulation pattern comprises a ramp portion that lasts about 9 days. 5. The method of claim 1, wherein the current is increased daily. 6. The method of claim 1, wherein the current increases by about 20% in a 24 hour period. 7. The method of claim 1, wherein the current reduces after one or more signal off times. 8. The method of claim 1, wherein the frequency reduces after one or more signal off times. 9. The method of claim 1, wherein the current reduces during one or more stimulation periods for about 1 day. 10. The method of claim 1, wherein the current reduces for about 4 days. 11. The method of claim 1, wherein the frequency reduces during one or more stimulation periods for about 3 days. 12. The method of claim 1, wherein the current reduces for between about 1 day and about 10 days. 13. The method of claim 1, wherein the signal off time varies. 14. The method of claim 1, wherein the frequency increases hourly for between about 1 day and about 5 days. 15. The method of claim 1, wherein the intermittent signal current increases from 0 mA to about 5 mA. 16. The method of claim 1, wherein the current increases from about ½ mA to about 5 mA. 17. The method of claim 1, wherein the increases stimulation intensity from 1.0 -5.0 mAmp-mSec. 18. The method according to claim 1, wherein the frequency changes from about 10 Hz to about 20 Hz. 19. The method according to claim 1, wherein abdominal fat is reduced. 20. The method according to claim 1, wherein liver fat is reduced. 21. The method according to claim 1, wherein the mammal has type II diabetes. 22. The method according to claim 1, wherein the stimulation intensity during the no-stimulation period is non-zero. 23. A method of electrically stimulating a splanchnic nerve in a mammal by applying a stimulation pattern to provide weight loss, the method comprising: applying an intermittent electrical signal comprising a frequency, a pulse width and a current to the splanchnic nerve, wherein the intermittent signal comprises a stimulation time period and a no stimulation time period and wherein the stimulation time period comprises a signal on time and a signal off time; changing the intermittent electrical signal frequently enough, and substantially enough to prevent compensation, wherein the changing intermittent electrical signal is configured to achieve a net weight loss over at least 28 days and wherein the intermittent electrical signal changes by varying one or more of the frequency from about 1 Hz to about 500 Hz, the current at intensities greater than 2 mA, the pulse width at lengths greater than 0.250 mSec, the duration of the signal off time or combinations thereof. 24. The method according to claim 23, wherein the signal off time is greater than the signal on time. 25. The method according to claim 23, wherein abdominal fat is reduced. 26. The method according to claim 23, wherein liver fat is reduced. 27. The method according to claim 23, wherein the mammal has type II diabetes. 28. The method according to claim 23, wherein the stimulation intensity during the no-stimulation period is non-zero.
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