A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invent
A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retaining structure. The retaining structure is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retaining structure may be penetrable by a fluid transfer device.
대표청구항▼
What we claim is: 1. A penetrable cap comprising: a core structure comprising: a closed side wall; a ledge extending radially inwardly from an inner surface of the side wall, the ledge defining an opening that is sized to receive a pipette tip therethrough; a first bore defined by the inner surface
What we claim is: 1. A penetrable cap comprising: a core structure comprising: a closed side wall; a ledge extending radially inwardly from an inner surface of the side wall, the ledge defining an opening that is sized to receive a pipette tip therethrough; a first bore defined by the inner surface of the side wall and a top surface of the ledge, the first bore extending from the top surface of the ledge to a top surface of the side wall; and attachment means for fixing the cap to an open end of a vessel in sealing engagement; a first frangible seal comprising a foil layer, the first frangible seal being affixed to a surface of the ledge to provide a fluid barrier between the first bore and fluid contents of a vessel; and a second frangible seal affixed to a top surface of the side wall, the second frangible seal being disposed over the first bore and in axial alignment with the first frangible seal, wherein the cap is capable of being penetrated by a plastic pipette tip, and wherein the cap is capable of being penetrated by a plastic pipette tip, and wherein air passageways are formed between the first and second frangible seals and a plastic pipette tip when the plastic pipette tip penetrates the first and second frangible seals, whereby air can be vented through the cap when the cap is secured to an open end of a vessel. 2. The cap of claim 1, wherein the core structure of the cap further comprises a skirt depending from the ledge, and wherein the skirt has an inner surface that defines a second bore having a diameter that is smaller than the diameter of the first bore. 3. The cap of claim 1, wherein the core structure is a molded plastic piece to which the first and second frangible seals are affixed. 4. The cap of claim 1, wherein the second frangible seal comprises a foil layer. 5. The cap of claim 4, wherein each of the first and second frangible seals further comprises a brittle layer. 6. The cap of claim 4, wherein each of the first and second frangible seals further comprises a heat seal layer and an intervening brittle layer. 7. The cap of claim 4, wherein each of the first and second frangible seals further comprises a combined brittle/heat seal layer. 8. The cap of claim 1, wherein at least one of the first and second frangible seals is modified to facilitate penetration by a plastic pipette tip, wherein the modification reduces the tensile strength of at least one of the first and second frangible seals. 9. The cap of claim 1, wherein neither of the first and second frangible seals is modified to facilitate penetration by a plastic pipette tip by reducing the tensile strength of at least one of the first and second frangible seals. 10. The cap of claim 1 further comprising a filter interposed between the first and second frangible seals. 11. The cap of claim 10, wherein the filter is comprised of a resilient material. 12. The cap of claim 10, wherein the filter is gas permeable. 13. The cap of claim 12, wherein the filter is constructed and arranged to trap an aerosol and/or bubbles. 14. A collection device comprising the cap of claim 1 secured to an open end of a fluid-holding vessel, thereby providing a substantially leak-proof seal. 15. A kit comprising the collection device of claim 14 in packaged combination with a specimen-retrieval device. 16. The kit of claim 15, wherein the core structure of the cap further comprises a skirt depending from the ledge, and wherein the skirt has an inner surface that defines a second bore having a diameter that is smaller than the diameter of the first bore. 17. The kit of claim 15, wherein the second frangible seal comprises a foil layer. 18. The kit of claim 15, wherein the specimen-retrieval device is a swab. 19. A method for removing a fluid substance from the collection device of claim 14, the method comprising the steps of: (a) penetrating the first and second frangible seals with a plastic pipette tip, thereby forming air passageways between the plastic pipette tip and the first and second frangible seals; (b) drawing a fluid substance in the vessel into the plastic pipette tip; and (c) removing the plastic pipette tip from the collection device. 20. The method of claim 19, wherein the core structure of the cap farther comprises a skirt depending from the ledge, and wherein the skiff has an inner surface that defines a second bore having a diameter that is smaller than the diameter of the first bore. 21. The method of claim 19, wherein the second frangible seal comprises a foil layer. 22. The method of claim 19 further comprising a filter interposed between the first and second frangible seals. 23. The method of claim 22, wherein the filter is comprised of a resilient material. 24. The method of claim 22, wherein the filter is gas permeable. 25. The cap of claim 24, wherein the filter impedes or prevents the release of an aerosol and/or bubbles from the collection device during step (a). 26. The method of claim 19, wherein the fluid substance comprises a biological specimen. 27. The method of claim 26, wherein the collection device contains a specimen-retrieval device within an interior space of the collection device. 28. The method of claim 27, wherein the specimen-retrieval device is a swab. 29. The method of claim 19 further comprising, after step (c), the step of amplifying a target nucleic acid sequence present in the fluid substance removed from the collection device in step (c).
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