초록

Compositions comprising a catechin as found in green tea, e.g., epigallocatechin gallate, and ligand which activates the peroxisome proliferatoractivated receptor gamma (PPAR-gamma are useful for the treatment and prevention of diabetes mellitus).

대표청구항 ▼

What is claimed is: 1. A solid unit oral dosage form for effecting glucose tolerance and inhibiting body weight gain or adipose tissue weight gain associated with use of a PPARγ ligand, comprising a catechin found in green tea, and a peroxisome proliferator-activated receptor gamma (PPAR;

What is claimed is: 1. A solid unit oral dosage form for effecting glucose tolerance and inhibiting body weight gain or adipose tissue weight gain associated with use of a PPARγ ligand, comprising a catechin found in green tea, and a peroxisome proliferator-activated receptor gamma (PPARγ) ligand selected from the group consisting of thiazolidinediones, ligustilide and phytanic acid, wherein the catechin and the PPARγ ligand are present in glucose lowering amounts. 2. The solid unit oral dosage form according to claim 1 wherein the catechin is (−) epigallocatechin gallate. 3. The solid unit oral dosage form according to claim 2 wherein (−) epigallocatechin gallate is present in an amount of about 10 mg to about 2000 mg. 4. The solid unit oral dosage form according to claim 1 wherein the PPARγ ligand is ligustilide. 5. The solid unit oral dosage form according to claim 1 wherein the PPARγ ligand is in a dosage of from about 1 to about 1000 mg. 6. The solid unit oral dosage form according to claim 1 wherein the catechin is (−) epigallocatechin gallate and (−) epigallocatechin gallate is present in an amount of from about 10 mg to about 2000 mg, and wherein the PPARγ ligand is present in an amount of from about 1 to about 1000 mg. 7. The solid unit oral dosage form according to claim 6 wherein the PPARγ ligand is ligustilide. 8. The solid unit oral dosage form according to claim 6 wherein the (−)-epigallocatechin gallate is present in an amount of about 2000 mg, and PPARγ ligand is present in an amount of about 1000 mg. 9. The solid unit dosage form according to claim 1, wherein the thiazolidinediones are selected from the group consisting of ciglitazone, rosiglitazone, and pioglitazone. 10. A solid unit oral dosage form for effecting glucose tolerance comprising an effective amount of a catechin found in green tea, and of a peroxisome proliferator-activated receptor gamma (PPARγ) ligand selected from the group consisting of thiazolidinediones, ligustilide and phytanic acid, wherein the effective amount of each of the catechin and the PPARγ ligand in combination reduces fasted state glucose concentration and inhibits body weight gain or adipose tissue weight gain associated with use of a PPARγ ligand. 11. The pharmaceutical composition solid unit oral dosage form according to claim 10 wherein the PPARγ ligand is ligustilide. 12. The pharmaceutical composition solid unit oral dosage form according to claim 10 wherein the catechin is (−) epigallocatechin gallate and (−) epigallocatechin gallate is present in an amount of from about 10 mg to about 2000 mg, and wherein the PPARγ ligand is present in an amount of from about 1 to about 1000 mg. 13. The solid unit oral dosage form according to claim 6 wherein the (−)-epigallocatechin gallate is present in an amount of from 100 mg to 300 mg, and the PPARγ ligand is present in an amount of from 8 mg to 100 mg. 14. The solid unit dosage form according to claim 10, wherein the thiazolidinediones are selected from the group consisting of ciglitazone, rosiglitazone, and pioglitazone.