Method and apparatus for transferring heat to or from an organ or tissue container
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01N-001/02
F25D-003/08
출원번호
UP-0815853
(2004-04-02)
등록번호
US-7691622
(2010-05-20)
발명자
/ 주소
Garland, Jeffrey C.
Schein, Douglas
Wright, David Walter
출원인 / 주소
Lifeline Scientific, Inc.
대리인 / 주소
Oliff & Berridge, PLC.
인용정보
피인용 횟수 :
19인용 특허 :
93
초록▼
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the cassette and transporter
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the cassette and transporter with heat transfer surfaces arranged to transfer heat between a cooling source in said transporter and the heat transfer surfaces of the cassette.
대표청구항▼
What is claimed is: 1. Apparatus for holding an organ or a tissue for at least one of perfusion, storage, diagnosis and transport of the organ or tissue, comprising: an organ or tissue transporter being configured to perfuse an organ or a tissue; a portable housing having one or more heat transfer
What is claimed is: 1. Apparatus for holding an organ or a tissue for at least one of perfusion, storage, diagnosis and transport of the organ or tissue, comprising: an organ or tissue transporter being configured to perfuse an organ or a tissue; a portable housing having one or more heat transfer surfaces; a compartment within the transporter having one or more heat transfer surfaces arranged on an outer surface of the compartment to transfer heat between a cooling source contained within the compartment and at least a part of one of the one or more heat transfer surfaces of the portable housing, the compartment being liquid-tight and preventing contact between a liquid contained within the compartment and the portable housing; and an organ or tissue supporting surface configured to support the organ or tissue within said portable housing, wherein the portable housing is configured to be received by the transporter and wherein at least a portion of at least one of the one or more heat transfer surfaces of the compartment is in contact with at least a portion of at least one of the one or more heat transfer surfaces of the portable housing to allow effective heat transfer to or from the contents of the portable housing. 2. The apparatus of claim 1, wherein the cooling source is a cooling fluid. 3. The apparatus of claim 2, wherein the cooling fluid is a cryogenic fluid. 4. The apparatus of claim 3, wherein the cryogenic fluid is at least one of ice, water, and a combination of water and ice. 5. The apparatus of claim 1, wherein the supporting surface is configured to support the organ or tissue while allowing effluent medical fluid to pass through said organ or tissue. 6. The apparatus of claim 1, wherein the outer surface of compartment and the portable housing have substantially complementary configurations. 7. The apparatus of claim 6, wherein a majority of at least one of the one or more heat transfer surfaces of the compartment is in contact with a majority of at least one of the one or more heat transfer surfaces of the portable housing. 8. The apparatus of claim 6, wherein substantially all of at least one of the one or more heat transfer surfaces of the compartment is in contact with substantially all of at least one of the one or more heat transfer surfaces of the portable housing. 9. The apparatus of claim 6, wherein the portable housing is configured to mate with the compartment. 10. The apparatus of claim 6, wherein each of the compartment and the portable housing have multiple heat transfer surfaces forming the outer surface of compartment and the portable housing, wherein the multiple heat transfer surfaces of each of the compartment and the portable housing are arranged such that a side cross-sectional view forms a trapezoid. 11. The apparatus of claim 6, wherein the outer surface of the compartment and the portable housing have complementary configurations forming a truncated cone. 12. The apparatus of claim 6, wherein the one or more heat transfer surfaces of the compartment and the one or more heat transfer surfaces of the portable housing are planar surfaces. 13. The apparatus of claim 6, wherein the one or more heat transfer surfaces of the compartment and the one or more heat transfer surfaces of the portable housing are non-planar surfaces. 14. The apparatus of claim 1, wherein the portable housing includes openings configured to allow tubing to pass through said openings and be connected to the organ. 15. The apparatus of claim 14, wherein the tubing can pass through the openings when the portable housing is mated with the compartment. 16. The apparatus of claim 14, wherein the tubing is configured to be mated with the portable housing, when the portable housing is removed from the compartment. 17. The apparatus of claim 1, wherein the transporter includes a heater. 18. The apparatus of claim 1, wherein the portable housing includes a handle that is accessible when the portable housing is mated with the compartment. 19. The apparatus of claim 1, wherein a bottom portion of the portable housing is liquid-tight and configured to collect medical fluid that has passed through a perfused organ to form an organ bath. 20. The apparatus of claim 1, wherein the transporter includes at least one sensor configured to detect a presence of the portable housing within the compartment. 21. A method of transporting an organ or a tissue, comprising: placing the organ or tissue in a portable housing, the portable housing having one or more heat transfer surfaces; placing the portable housing containing the organ or tissue in a compartment of a transporter configured to receive the portable housing and configured to perfuse the organ or tissue, the compartment having one or more heat transfer surfaces arranged on an outer surface of the compartment, the compartment being liquid-tight and preventing contact between a liquid contained within the compartment and the portable housing, wherein at least a portion of at least one of the one or more heat transfer surfaces of the compartment is in contact with at least a portion of at least one of the one or more heat transfer surfaces of the portable housing; transferring heat between a cooling source contained within the compartment, via at least a part of one of the one or more heat transfer surfaces of the compartment, to or from the contents of the portable housing; and transporting the organ in said portable housing in said transporter. 22. The method of claim 21, further comprising placing the portable housing containing the organ in an organ or tissue diagnostic device configured to receive the portable housing; and diagnosing the organ or tissue without removal of the organ from the portable housing. 23. The method of claim 21, further comprising placing the portable housing containing the organ or tissue in a perfusion device configured to receive the portable housing; and perfusing the organ or tissue without removal of the organ from the portable housing. 24. The method of claim 21, further comprising connecting tubing to the organ. 25. The method of claim 21, wherein the cooling source is a cooling fluid. 26. The method of claim 25, wherein the cooling fluid is a cryogenic fluid. 27. The method of claim 26, wherein the cryogenic fluid is at least one of ice, water, and a combination of ice and water. 28. The method of claim 25, wherein a bottom portion of the housing is liquid-tight and configured to collect medical fluid that has passed through a perfused organ to form an organ bath. 29. The method of claim 28, further comprising cooling the medical fluid with the cooling fluid. 30. The method of claim 21, wherein the outer surface of the compartment and the portable housing have substantially complementary configurations. 31. The method of claim 30, wherein each of the compartment and the portable housing have multiple heat transfer surfaces forming the outer surface of the compartment and the portable housing, wherein the multiple heat transfer surfaces of each of the compartment and the portable housing are arranged such that a side cross-sectional view forms a trapezoid. 32. The method of claim 30, wherein the outer surface of the compartment and the portable housing have complementary configurations forming a truncated cone. 33. The method of claim 21, wherein the portable housing includes tubing and connection devices to allow connection of an organ in the portable housing to tubing of at least one of the transporter, the organ diagnosis device and the organ perfusion device. 34. The method of claim 21, wherein the portable housing includes a handle and the handle is accessible when the portable housing is mated with the compartment. 35. The method of claim 21, wherein the one or more heat transfer surfaces of the compartment and the one or more heat transfer surfaces of the portable housing are planar surfaces. 36. The method of claim 21, wherein the one or more heat transfer surfaces of the compartment and the one or more heat transfer surfaces of the portable housing are non-planar surfaces. 37. The method of claim 21, wherein the portable housing includes openings configured to allow tubing to pass through said openings and be connected to the organ. 38. The method of claim 37, wherein the tubing can pass through the openings when the portable housing is mated with the compartment. 39. The method of claim 21, wherein the transporter includes a heater to heat the cooling source. 40. The method of claim 39, further comprising transferring heat from the cooling source to the medical fluid. 41. The method of claim 21, wherein the transporter includes at least one sensor configured to detect a presence of the portable housing within the compartment. 42. A system for holding an organ or tissue for transport of the organ or tissue, comprising: an organ or tissue transporter; a portable housing having one or more heat transfer surfaces; a compartment within the transporter having one or more heat transfer surfaces arranged on an outer surface of the compartment to transfer heat between a cooling source contained within the compartment and at least a part of one of the one or more heat transfer surfaces of the portable housing, the compartment being liquid-tight and preventing contact between a liquid contained within the compartment and the portable housing; and an organ or tissue supporting surface configured to support an organ or tissue within said portable housing; wherein the portable housing is configured to be received by the transporter and wherein at least a portion of at least one of the one or more heat transfer surfaces of the compartment is in contact with at least a portion of at least one of the one or more heat transfer surfaces of the portable housing to allow effective heat transfer to or from the contents of the portable housing, wherein the portable housing includes openings configured to allow tubing to pass through said openings and be connected to the organ, the tubing being configured to pass through the openings when the portable housing is mated with the compartment and being configured to be mated with the portable housing when the portable housing is removed from the compartment, and wherein the portable housing includes a handle that is accessible when the portable housing is mated with the compartment. 43. The system of claim 42, wherein the cooling source is a cooling fluid. 44. The system of claim 43, wherein the cooling fluid is a cryogenic fluid. 45. The system of claim 44, wherein the cryogenic fluid is at least one of ice, water, and a combination of water and ice. 46. The system of claim 42, wherein the supporting surface is configured to support the organ or tissue while allowing effluent medical fluid to pass through said organ or tissue. 47. The system of claim 42, wherein the outer surface of the compartment and the portable housing have substantially complementary configurations. 48. The system of claim 47, wherein a majority of at least one of the one or more heat transfer surfaces of the compartment is in contact with a majority of at least one of the one or more heat transfer surfaces of the portable housing. 49. The system of claim 47, wherein substantially all of at least one of the one or more heat transfer surfaces of the compartment is in contact with substantially all of at least one of the one or more heat transfer surfaces of the portable housing. 50. The system of claim 47, wherein the portable housing is configured to mate with the outer surface of the compartment. 51. The system of claim 47, wherein each of the compartment and the portable housing have multiple heat transfer surfaces forming the outer surface of the compartment and the portable housing, wherein the multiple heat transfer surfaces of each of the compartment and the portable housing are arranged such that a side cross-sectional view forms a trapezoid. 52. The system of claim 47, wherein the outer surface of the compartment and the portable housing have complementary configurations forming a truncated cone. 53. The system of claim 47, wherein the one or more heat transfer surfaces of the compartment and the one or more heat transfer surfaces of the portable housing are planar surfaces. 54. The system of claim 47, wherein the one or more heat transfer surfaces of the compartment and the one or more heat transfer surfaces of the portable housing are non-planar surfaces. 55. The system of claim 42, wherein the transporter includes a heater. 56. The system of claim 42, wherein a bottom portion of the portable housing is liquid-tight and configured to collect medical fluid that has passed through a perfused organ to form an organ bath. 57. The system of claim 42, further comprising: at least one of an organ perfusion device and an organ diagnostic device, wherein the portable housing is configured to be received by the at least one organ perfusion device and the organ diagnostic device and to allow at least one of perfusion and diagnosis of the organ without removal of the organ from the portable housing. 58. The system of claim 42, wherein the transporter includes at least one sensor configured to detect a presence of the portable housing within the compartment. 59. The system of claim 58, wherein the portable housing includes identification information, and wherein the sensor identifies the portable housing by reading the identification information. 60. The system of claim 42, wherein the transporter is configured to perfuse the organ or tissue. 61. Apparatus for holding an organ or a tissue for at least one of perfusion, storage, diagnosis and transport of the organ or tissue, comprising: an organ or tissue transporter; a portable housing having one or more heat transfer surfaces; a compartment within the transporter having one or more heat transfer surfaces arranged on an outer surface of the compartment to transfer heat between a cooling source contained within the compartment and at least a part of one of the one or more heat transfer surfaces of the portable housing, the compartment being liquid-tight and preventing contact between a liquid contained within the compartment and the portable housing; and an organ or tissue supporting surface configured to support the organ or tissue within said portable housing, wherein the portable housing is configured to be received by the transporter and wherein at least a portion of at least one of the one or more heat transfer surfaces of the compartment is in contact with at least a portion of at least one of the one or more heat transfer surfaces of the portable housing to allow effective heat transfer to or from the contents of the portable housing, wherein the portable housing includes openings configured to allow tubing to pass through said openings and be connected to the organ or tissue, and wherein the tubing can pass through the openings when the portable housing is mated with the compartment. 62. A method of transporting an organ or a tissue, comprising: placing the organ or tissue in a portable housing, the portable housing having one or more heat transfer surfaces; placing the portable housing containing the organ or tissue in a compartment of a transporter configured to receive the portable housing, the compartment having one or more heat transfer surfaces arranged on an outer surface of the compartment, the compartment being liquid-tight and preventing contact between a liquid contained within the compartment and the portable housing, wherein at least a portion of at least one of the one or more heat transfer surfaces of the compartment is in contact with at least a portion of at least one of the one or more heat transfer surfaces of the portable housing; transferring heat between a cooling source contained within the compartment, via at least a part of one of the one or more heat transfer surfaces of the compartment, to or from the contents of the portable housing; and transporting the organ in said portable housing in said transporter, wherein the portable housing includes openings configured to allow tubing to pass through said openings and be connected to the organ, and wherein the tubing can pass through the openings when the portable housing is mated with the compartment.
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