IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
|
| 출원번호 |
UP-0800538
(2007-05-07)
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| 등록번호 |
US-7695979
(2010-05-20)
|
|
발명자
/ 주소 |
- Sayre, Curtis
- Cohen, David
- Kaylor, Rosann
|
| 출원인 / 주소 |
- Kimberly-Clark Worldwide, Inc.
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| 대리인 / 주소 |
|
| 인용정보 |
피인용 횟수 :
0 인용 특허 :
176 |
초록
▼
A biosensor includes a substrate with a layer of receptive material disposed thereon overlying a layer containing a photo-reactive agent. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the receptive material are defined in the receptive mater
A biosensor includes a substrate with a layer of receptive material disposed thereon overlying a layer containing a photo-reactive agent. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the receptive material are defined in the receptive material layer by a masking process wherein the photo-reactive agent is activated in the exposed regions of the mask.
대표청구항
▼
What is claimed is: 1. A biosensor, comprising: a substrate member defining a surface; a photo-reactive agent overlying the surface of said substrate member; a receptive material layer applied directly over said photo-reactive agent and generally uniformly covering said surface of said substrate me
What is claimed is: 1. A biosensor, comprising: a substrate member defining a surface; a photo-reactive agent overlying the surface of said substrate member; a receptive material layer applied directly over said photo-reactive agent and generally uniformly covering said surface of said substrate member, said receptive material being specific for an analyte of interest; wherein a pattern of active and inactive areas is defined by said receptive material layer, said active and inactive areas formed by a masking process wherein a mask is placed over said substrate member prior to irradiating said substrate member with an energy source sufficient for activating said photo-reactive agent such that areas exposed by said mask define said pattern of inactive areas of said receptive material and said areas shielded by said mask define said pattern of active areas of receptive material; and wherein said biosensor is configured to detect the presence of an analyte of interest when exposed to a medium containing said analyte of interest by binding the analyte to said receptive material in said active areas and subsequently facilitate diffraction of transmitted light or reflected light in a diffraction pattern corresponding to said active areas. 2. The biosensor as in claim 1, wherein said substrate comprises a material from the list of materials consisting of plastics, metal coated plastics and glass, functionalized plastics and glass, silicon wafers, foils, glass, and polymer films. 3. The biosensor as in claim 1, wherein said photo-reactive agent is applied as a layer on said substrate member. 4. The biosensor as in claim 1, wherein said diffraction pattern is visible to a naked eye of a user. 5. The biosensor as in claim 1 wherein said receptive material is protein based. 6. The biosensor as in claim 5, wherein said receptive material is an antibody. 7. The biosensor as in claim 1, wherein said substrate member is irradiated with UV light at a wavelength sufficient for activating said photo-reactive agent exposed through said mask. 8. The biosensor as in claim 1, wherein said receptive material is at least one of an antigen, antibody, nucleotide, chelator, enzyme, bacteria, yeast, fungi, virus, bacterial pili, bacterial flagellar material, nucleic acid, polysaccharide, lipid, protein, carbohydrate, metal, hormone, aptamer, peptide, and respective receptor for said materials. 9. The biosensor as in claim 1, wherein said analyte of interest is at least one of a bacteria, yeast, fungus, virus, rheumatoid factor, IgG, IgM, IgA, IgD, and IgE antibodies, carcinoembryonic antigen, streptococcus Group A antigen, viral antigens, antigens associated with autoimmune disease, allergens, tumor antigens, streptococcus group B antigen, HIV I or HIV II antigen, antibodies viruses, antigens specific to RSV, an antibody, antigen, enzyme, hormone, polysaccharide, protein, lipid, carbohydrate, drug, nucleic acid, Neisseria meningitides groups A, B, C, Y and W sub 135, Streptococcus pneumoniae, E. coli K1, Haemophilus influenza type A/B, an antigen derived from microorganisms, PSA and CRP antigens, a hapten, a drug of abuse, a therapeutic drug, an environmental agents, or antigens specific to Hepatitis. 10. The biosensor as in claim 1, wherein said photo-reactive agent is a photo-acid agent. 11. The biosensor as in claim 1, wherein said photo-reactive agent is a photo-oxidant agent. 12. The biosensoras in claim 1, wherein the photo-oxidant agent comprises gold. 13. The biosensor as in claim 1, wherein the photo-oxidant agent comprises chromium. 14. A biosensor, comprising: a substrate member defining a surface; a photo-reactive agent overlying the surface of the substrate member; a receptive material layer molecularly attached to the photo-reactive agent, the receptive material being specific for an analyte of interest; wherein the receptive material layer defines active areas and inactive areas; wherein the active areas are configured to bind to an analyte of interest, and wherein the inactive areas comprise activated photo-reactive agent and denatured receptive material such that the denatured receptive material does not bind to the analyte of interest; wherein the biosensor is configured to detect the presence of an analyte of interest in a medium through diffraction of transmitted light or reflected light. 15. The biosensor as in claim 14, wherein active areas of the receptive material layer correspond to areas shielded by a mask protecting the underlying photo-reactive agent from irradiation from an energy source. 16. The biosensor as in claim 14, wherein the inactive areas of the receptive material layer correspond to areas of the photo-reactive agent irradiated by an energy source. 17. The biosensor as in claim 14, wherein the photo-reactive agent comprises a photo-acid agent. 18. The biosensor as in claim 14, wherein the photo-reactive agent comprises a photo-oxidant agent. 19. The biosensor as in claim 18, wherein the photo-oxidant agent comprises gold. 20. The biosensor as in claim 18, wherein the photo-oxidant agent comprises chromium.
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