[특허]Systems and methods for radioisotope generation

Draximage General Partnership

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특허 상세정보

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Systems and methods for radioisotope generation

특허상세정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G21G-001/04 G21F-005/015
미국특허분류(USC)	250/432.PD; 422/159; 423/249
출원번호	UP-0773022 (2007-07-03)
등록번호	US-7700926 (2010-05-20)
발명자 / 주소	Tartaglia, Daniel Coppola, Carlo Teoli, Vince Bournival, Alain Guy
출원인 / 주소	Draximage General Partnership
대리인 / 주소	Woodcock Washburn LLP
인용정보	피인용 횟수 : 11 인용 특허 : 22

초록
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Systems and methods are disclosed for producing customized, predictable and reproducible supplies of radioisotopes using, for example, a reactor housing that is fabricated from a radioactive shielding material and has both an internal volume and a surface that comprises an entry port and an exit port, a chromatographic column that is positioned within said internal volume such that a first end of said column is in fluid communication with said entry port and a second end of said column is in fluid communication with said exit port, and a changeable filte...

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What is claimed: 1. A system comprising: a reactor housing that is fabricated from a radioactive shielding material and has both an internal volume and a surface that comprises an entry port and an exit port; a chromatographic column that bears at least one radioisotope and is positioned within said internal volume; a filter module that is disposed external to said reactor housing and in fluid communication with said column; an adapter disk disposed on said reactor housing, comprising a ridge of material that extends around said entry port and a ridge of material that extends around said exit port, and, an adapter ridge disposed circumferentially internal to said ridge of material that extends around said entry port. 2. The system of claim 1 wherein said radioactive shielding material is lead, tungsten or depleted uranium. 3. The system of claim 1 wherein said reactor housing is substantially rectilinear. 4. The system of claim 1 wherein said reactor housing is substantially cylindrical. 5. The system of claim 1 wherein said reactor housing includes a first end, a second end, and a wall extending between said first end and said second end. 6. The system of claim 5 wherein said entry port and said exit port are positioned at said first end. 7. The system of claim 6 further comprising a ridge of radioactive shielding material extending around said entry port at said first end. 8. The system of claim 6 further comprising a ridge of radioactive shielding material extending around said exit port at said first end. 9. The system of claim 1 wherein said column comprises aluminum oxide particles from about 50 to about 200 μm in size. 10. The system of claim 1 wherein said column comprises silica gel particles from about 20 to about 100 μm in size. 11. The system of claim 1 wherein said column comprises one or more layers or polypropylene filter membranes, deactivated fused silica wool, one or more glass filter membranes from about 0.2 to about 10 μm in size and/or stainless steel tubing with needle and filter adaptors. 12. The system of claim 11 further comprising funnel drains. 13. The system of claim 1 wherein said filter module comprises a sterile 13 to 25 mm filter membrane from about 0.1 to about 0.22 μm size. 14. The system of claim 1 wherein said filter module is attached to said reactor vessel by a thread type adaptor. 15. The system of claim 14 wherein a needle is attached to said filter module. 16. The system of claim 1 wherein a collection housing is connected to said reactor housing via said filter module. 17. The system of claim 1 wherein said at least one radioisotope is Molybdate Mo-99. 18. The system of claim 1 wherein said at least one radioisotope is Pertechnetate Tc99m. 19. The system of claim 1 further comprising a delivery vessel that is disposed external to said reactor housing and in fluid communication with said column. 20. The system of claim 19 wherein said delivery vessel is contained within a delivery housing that is fabricated from radioactive shielding material. 21. The system of claim 20 wherein said delivery housing has a first end that includes a first coupling, a second end that includes a second coupling, and a wall extending between said first end and said second end. 22. The system of claim 21 wherein said first coupling is threaded. 23. The system of claim 21 further comprising a transfer tool that comprises a pick-up and release rod having a handle at a first end thereof and a coupling at a second end thereof that is compatible with said first coupling. 24. The system of claim 23 wherein said transfer tool is a T-bar handle. 25. The system of claim 19 wherein said delivery vessel comprises a solution of at least one radioisotope. 26. The system of claim 25 wherein said at least one radioisotope is Molybdate Mo-99. 27. The system of claim 25 wherein said solution is Sodium Molybdate Mo-99. 28. The system of claim 25 wherein said delivery vessel comprises about 1 to about 50 Ci. 29. The system of claim 19 wherein said delivery vessel comprises Normal Saline [0.9%] solution. 30. The system of claim 20 wherein said delivery housing abuts a ridge of material that is external to said reactor housing and extends around said entry port. 31. The system of claim 20 wherein said delivery housing is at least partially contained within a ridge of material that is external to said reactor housing and extends around said entry port. 32. The system of claim 19 wherein said delivery vessel is at least partially contained within a ridge of material that is external to said reactor housing and extends around said entry port. 33. The system of claim 1 further comprising a collection vessel that is disposed external to said reactor housing and in fluid communication with said column via said filter module. 34. The system of claim 1 wherein said collection vessel is evacuated. 35. The system of claim 1 wherein said collection vessel comprises a solution of at least one radioisotope. 36. The system of claim 35 wherein said at least one radioisotope is Technetium Tc99m. 37. The system of claim 35 wherein said solution is Sodium Pertechnetate Tc-99m. 38. The system of claim 1 further comprising a saline vessel that is disposed external to said reactor housing and in fluid communication with said column. 39. The system of claim 38 wherein said saline vessel comprises Normal Saline [0.9%] solution. 40. The system of claim 1 wherein said filter module abuts a ridge of radioactive shielding material that is external to said reactor housing and extends around said exit port. 41. The system of claim 1 wherein said filter module is at least partially contained within a ridge of radioactive shielding material that is external to said reactor housing and extends around said exit port. 42. The system of claim 1 wherein said collection vessel is contained within a collection housing that is fabricated from radioactive shielding material. 43. The system of claim 42 wherein said collection housing abuts a ridge of material that is external to said reactor housing and extends around said exit port. 44. The system of claim 42 wherein said collection housing is at least partially contained within a ridge of material that is external to said reactor housing and extends around said exit port. 45. The system of claim 1 further comprising a cart that includes a plurality of delivery vessels that each independently comprises a reactor vessel. 46. The system of claim 1 further comprising a cart that includes a plurality of delivery vessels that each independently comprise a solution of at least one radioisotope and are contained within a delivery housing that is fabricated from radioactive shielding material. 47. The system of claim 46 further comprising a conveyor belt for moving said delivery housing. 48. The system of claim 46 further comprising a transfer tool for moving said delivery housing. 49. The system of claim 46 wherein said at least one radioisotope is Molybdenum-99. 50. The system of claim 46 wherein said solution is Sodium Molybdate Mo 99. 51. The system of claim 46 wherein said delivery vessels each independently comprise about 1 to about 50 Ci. 52. The system of claim 1 further comprising a cart that includes a plurality of evacuated collection vessels. 53. The system of claim 1 further comprising a cart that includes a plurality of saline vessels. 54. The system according to claim 1 wherein said column is configured to be reloaded with radioisotope solution at least once. 55. The system according to claim 54 wherein said column is configured to be reloaded with radioisotope solution at least two times, at least four times, or at least six times. 56. The system according to claim 28 wherein said column is configured to be reloaded with radioisotope solution from a further delivery vessel at least once. 57. The system according to claim 56 wherein said column is configured to be reloaded with radioisotope solution from a further delivery vessel at least two times, at least four times, or at least six times. 58. The system according to claim 1 further comprising a column assembly comprising a further chromatographic column for replacing said chromatographic column after said at least some of said radioisotope has been eluted therefrom. 59. The system according to claim 58 wherein said further chromatographic column is configured to be reloaded with radioisotope solution one to six times. 60. The system according to claim 58 wherein said further chromatographic column is configured to be reloaded with radioisotope solution more than six times.

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이 특허를 인용한 특허 피인용횟수: 11

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Systems and methods for radioisotope generation

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