초록 ▼

An apparatus for the handling of hazardous fluids includes a collection vessel, a collection vessel connector, a dose control connector, a unit dose container, a delivery control connector, and a delivery site access device. The collection vessel contains the fluid prior to dispensing, the unit dose

An apparatus for the handling of hazardous fluids includes a collection vessel, a collection vessel connector, a dose control connector, a unit dose container, a delivery control connector, and a delivery site access device. The collection vessel contains the fluid prior to dispensing, the unit dose container contains a predetermined amount of the fluid for dispensing, the delivery site access device provides access to an intended delivery site, and the connector attaches pieces of the apparatus to one another. The method of the invention allows needle-free connections to be made for the apparatus, using a predetermined arrangement of the pieces of the apparatus, and in one embodiment, employs deformable elastomeric valves capable of creating a decreased pressure at a valve surface, so that upon closure of said valves, a fluid on the surface on the valves is withdrawn within the connector.

대표청구항 ▼

I claim: 1. A method for the handling of a radiopharmaceutical fluid comprising the steps of: a) enclosing a collection vessel volume (160) to be handled in a collection vessel (100) further comprising: (i) a collection vessel fluid port interlock (180), releasably interlockable to a collection ves

I claim: 1. A method for the handling of a radiopharmaceutical fluid comprising the steps of: a) enclosing a collection vessel volume (160) to be handled in a collection vessel (100) further comprising: (i) a collection vessel fluid port interlock (180), releasably interlockable to a collection vessel connector male end fluid port interlock (224); (ii) a collection vessel internal channel (110) in fluid communication with the collection vessel volume (160) and in fluid communication with a collection vessel fluid port (170) being reversibly sealed from the environment by a collection vessel fluid port elastomeric closure (172) being biased in favor of being sealed; b) releasably interlocking the collection vessel connector male end fluid port interlock (224) to the collection vessel fluid port interlock (180), thereby interlocking to the collection vessel (100) a collection vessel connector (200) having a connector vessel connector male end (220) and a collection vessel connector female end (230) further comprising; i) the collection vessel connector male end fluid port interlock (224); ii) a collection vessel connector male end fluid port (222) in fluid communication with a collection vessel connector internal channel (210); iii) a connection vessel connector female end fluid port (232) in fluid communication with the collection vessel connector internal channel (210); iv) the collection vessel connector internal channel (210) containing collection vessel connector internal channel deformable elastomeric valve (212) having a collection vessel connector internal channel deformable elastomeric valve male end (214) and a collection vessel connector internal channel deformable elastomeric valve female end (216); v) wherein the collection vessel connector internal channel deformable elastomeric valve female end (216) reversibly seals the collection vessel connector female end fluid port (232) from the collection vessel internal channel (210), and the collection vessel connector internal channel deformable elastomeric valve female end (216) is biased in favor of being sealed; vi) a collection vessel connector female end fluid port interlock (234); and said interlocking of the collection vessel connector male end fluid port interlock (224) to the collection vessel fluid port interlock (180) causing the collection vessel fluid port elastomeric closure (172) to reverse bias and become opened, thereby placing the collection vessel volume (160) in fluid communication with the collection vessel connector male end fluid port (222) and thereby in fluid communication with the collection vessel connector internal channel (210); c) releasably interlocking a unit dose container male end fluid port interlock (480) to a dose control connector female end fluid port interlock (334), thereby interlocking to a dose control connector (300) a unit dose container (400) further comprising; i) the unit dose container fluid port interlock (480); ii) a unit dose container internal channel (410) in fluid communication with a unit dose container volume (460) and in fluid communication with a unit dose container fluid port (470); and iii) a unit dose container fluid manipulation regulator (490) regulating the unit dose container volume (460); said interlocking of unit dose container fluid port interlock (480) and the dose control connector female end fluid port interlock (334) placing the unit dose connector internal channel (410), in fluid communication with the collection vessel connector internal channel (210); d) releasably interlocking a dose control connector male end fluid port interlock (324) to the collection vessel connector female end fluid port interlock (234), thereby interlocking to the collection vessel connector (200) a dose control connector (300) having a dose control connector male end (320) and a dose control connector female end (330) further comprising; i) the dose control connector male end fluid port interlock (324); ii) a dose control connector male end fluid port (322) in fluid communication with a dose control connector internal channel (310); iii) the dose control connector internal channel (310) containing a dose control connector deformable elastomeric valve (312) having a dose control connector deformable elastomeric valve male end (314) and a dose control connector deformable elastomeric valve female end (316); iv) wherein the dose control connector deformable elastomeric valve male end (312) reversibly seals the dose control connector male end fluid port (322) from the environment, the dose control connector elastomeric valve male end (312) being biased in favor of being sealed; v) a dose control female end fluid port (332) in fluid communication with the dose control connector internal channel (310); vi) a dose control connector female end fluid port interlock (334); and said interlocking of the dose control connector male end fluid port interlock (324) to the collection vessel connector female end fluid port interlock (234), causing the collection vessel connector deformable elastomeric valve female end (216) and the dose control connector deformable elastomeric valve male end (314) to reverse bias and become opened, thereby placing the collection vessel volume (160) in fluid communication with the dose control connector male end fluid port (322) and thereby in fluid communication with the dose control connector internal channel (310); e) withdrawing the radiopharmaceutical fluid from the collection vessel (100) through the collection vessel connector (200) thence through the dose control connector 300) and thence into the unit dose container (400) by manipulation of the unit dose container fluid manipulation regulator (490); f) releasably disengaging the dose control connector (300) from the collection vessel connector (200), the act of disengaging including the disengaging of the collection vessel connector female end fluid port interlock (234) and the dose control connector male end fluid port interlock (324), said disengaging causing the dose control connector internal channel deformable elastomeric valve male end (314) and the collection vessel connector internal channel deformable elastomeric valve female end (216) to reverse bias and become sealed, thereby interrupting the fluid communication between the dose control connector internal channel (310) and the collection vessel connector internal channel (210); g) suitably transporting the connected dose control connector (300) and unit dose container (400) to a point of use. 2. The method according to claim 1, further compromising the steps of: a) releasably attaching a delivery site access device (600) having a delivery site connector delivery site end (620) and a delivery site access device delivery site end fluid port (622) to a delivery site (S), thereby interlocking to the delivery site (S) a delivery site access device (600) having a delivery site access device female end (630) further comprising: i) a delivery site access device female end fluid port interlock (634); ii) a delivery site access device female end fluid port (632) in fluid communication with a delivery site access device internal channel (610) thence to the delivery site end fluid port (622) and thence to the delivery site (S); b) releasably interlocking a delivery control connector male end fluid port interlock (524) to the delivery site access device female end fluid port interlock (634), thereby interlocking to the delivery site (S) a delivery control connector (500) having a delivery control connector male end (520) and a delivery control connector female end (530) further comprising; i) the delivery control connector male end fluid port interlock (524); ii) a delivery control connector male end fluid port (522) in fluid communication with a delivery control connector internal channel (510); iii) the delivery control connector internal channel (510) containing a delivery control connector internal channel deformable elastomeric valve (512) having a delivery control connector internal channel deformable elastomeric valve male end (514) and a delivery control connector internal channel deformable elastomeric valve female end (516); iv) a delivery control connector female end fluid port (532) in fluid communication with the delivery control connector internal channel (510); v) wherein the delivery control connector internal channel deformable elastomeric valve female end (516) reversibly seals the delivery control connector female end fluid port (532) from the environment, the delivery control connector internal channel elastomeric valve female end (516) being biased in favor of being sealed; vi) said interlocking of the delivery control connector male end fluid port interlock (524) to the delivery site access device female end fluid port interlock (634) placing the delivery site (S) in fluid communication with the delivery site access device internal channel (610); c) releasably interlocking the dose control connector male end fluid port interlock (324) and the delivery control connector female end fluid port interlock (534), thereby interlocking the dose control connector (300) and the delivery control connector (500); said interlocking of the dose control connector male end fluid port interlock (324) and the delivery control connector female end fluid port interlock (534), causing the dose control connector internal channel deformable elastomeric valve male end (314) and the delivery control connector internal channel deformable elastomeric valve female end (516) to reverse bias and become opened and thereby to place the delivery control connector internal channel (510) and the dose control connector internal channel (310) in fluid communication with the unit dose container volume (460); d) dispensing the radiopharmaceutical fluid from the unit dose container (400) through the dose control connector (300) thence through the delivery control connector (500) and thence through the delivery site access device (600) to the delivery site (S) by means of manipulating the unit dose container fluid manipulation regulator (490); and e) releasably disengaging the dose control connector (300) from the delivery control connector (500), the act of disengaging including the disengaging of dose control connector male end fluid port interlock (324) and the delivery control connector female end fluid port interlock (534), said disengaging causing the dose control connector internal channel deformable elastomeric valve male end (314) and the delivery control connector internal channel deformable elastomeric valve female end (516) to reverse bias and thereby to reversibly interrupt the fluid communication between the dose control connector internal channel (310) and the delivery control connector internal channel (510). 3. The method according to claim 2, further comprising the steps of; a) removing the dose control connector (300) and unit dose container (400) from the point of use and suitably transporting the dose control connector (300) and unit dose container (400) for disposal; b) removing the delivery site access device (600) and delivery control connector (500) from the delivery site (S) and suitably transporting the connected delivery site access device (600) and delivery control connector (500) for disposal; and c) suitably disposing of the dose control connector (300), the unit dose container (400), the delivery control connector (500), and the delivery site access device (600). 4. The method according to claim 2, wherein the dose control connector internal channel deformable elastomeric valve female end (316) reversibly seals the dose control connector female end fluid port (334) from the environment, the dose control connector elastomeric valve female end (316) being biased in favor of being sealed; and the step of releasably interlocking the dose control connector female end fluid port interlock (334) to the unit dose container fluid port interlock (480) causes the dose control connector deformable elastomeric valve female end (316) to reverse bias and become opened. 5. The method according to claim 2, wherein the delivery control connector deformable internal channel elastomeric valve male end (514) reversibly seals the delivery control connector male end fluid port (522) from the environment, the delivery control connector internal channel elastomeric valve male end (514) being biased in favor of being sealed; and the step of reversibly interlocking the delivery control connector male end fluid port interlock (524) to the delivery site access device female end fluid port interlock (634) causes the delivery control connector internal channel deformable elastomeric valve male end (514) to reverse bias and become opened. 6. The method according to claim 2, wherein the act of releasably interlocking the collection vessel connector male end fluid port interlock (224) to the collection vessel fluid port interlock (180) further comprises puncturing a collection vessel connector male end fluid port ingress regulator (223) through a collection vessel fluid port puncturable resealable elastomeric seal (174), thereby placing the collection vessel connector male end fluid port (222) in fluid communication with the collection vessel volume (160). 7. The method according to claim 2, wherein the collection vessel (100), the collection vessel connector (200), the dose control connector (300), the unit dose container (400), the delivery control connector (500), and the delivery site access device (600) are matched in coloration. 8. The method according to claim 2, wherein the act of releasably interlocking the collection vessel connector male end fluid port interlock (224) to the collection vessel fluid port interlock (180), further requires the engagement of a first interlock safety feature (555) on the collection vessel (100) and a cooperating second interlock safety feature (666) on the collection vessel connector (200). 9. The method according to claim 2, wherein the act of releasably interlocking a dose control connector male end fluid port interlock (324) to the collection vessel connector female end fluid port interlock (234), further requires the engagement of a third interlock safety feature (777) on the collection vessel connector (200) and a cooperating fourth interlock safety feature (888) on the dose control connector (300). 10. The method according to claim 2, wherein the act of releasably interlocking a unit dose container male end fluid port interlock (480) to the dose control connector fluid port interlock (334), further requires the engagement of a third interlock safety feature (777) on the dose control connector (300) and a cooperating fourth interlock safety feature (888) on the unit dose container (400). 11. The method according to claim 2, wherein the act of releasably disengaging the dose control connector (300) from the collection vessel connector (200), further requires the disengagement of a third interlock safety feature (777) on the collection vessel connector (200) and a cooperating fourth interlock safety feature (888) on the dose control connector (300). 12. The method according to claim 2, wherein the act of releasably interlocking a delivery control connector male end fluid port interlock (524) to the delivery site access device female end fluid port interlock (634), further requires the engagement of a third interlock safety feature (777) on the delivery site access device (600) and a cooperating fourth interlock safety feature (888) on the delivery control connector (500). 13. The method according to claim 2, wherein the act of releasably interlocking the dose control connector male end fluid port interlock (324) to the delivery control female end fluid port interlock (534), further requires the engagement of a third interlock safety feature (777) on the delivery control connector (500) and a cooperating fourth interlock safety feature (888) on the dose control connector (300). 14. The method according to claim 2, wherein the act of releasably disengaging the dose control connector (300) from the delivery control connector (500), further requires the disengagement of a third interlock safety feature (777) on the delivery control connector (500) and a cooperating fourth interlock safety feature (888) on the dose control connector. 15. The method according to claim 2, wherein the act of suitably transporting the connected dose control connector (300) and unit dose container (400) to a point of use further comprises enclosing the connected dose control connector (300) and unit dose container (400) in a closed container having an adsorbent inner layer and a moisture resistant outer layer. 16. The method according to claim 2, wherein the act of suitably transporting the connected dose control connector (300) and unit dose container (400) to a point of use further comprises enclosing the connected dose control connector (300) and unit dose container (400) in a radiation shielded container. 17. The method according to claim 2, wherein the step of disengaging the dose control connector (300) and the collection vessel connector (200) thereby causing the dose control connector internal channel deformable elastomeric valve male end (314) and the collection vessel connector internal channel deformable elastomeric valve female end (216) to reverse bias and become sealed, thereby reversibly interrupting the fluid communication between the dose control connector internal channel (310) and the collection vessel connector internal channel (210); further comprises the act of reversing bias and becoming sealed creating a decreased pressure at the collection vessel connector female end fluid port (232), the decreased pressure withdrawing substantially all of the fluid remaining on a surface of the collection vessel connector female end fluid port (232) into the collection vessel connector internal channel (210). 18. The method according to claim 2, wherein the step of disengaging the dose control connector (300) and the delivery control connector (500) causes the dose control connector internal channel deformable elastomeric valve male end (314) and the delivery control connector internal channel deformable elastomeric valve female end (516) to reverse bias and thereby to reversibly interrupt the fluid communication between the dose control connector internal channel (310) and the delivery control connector internal channel (510), further comprises the act of reversing bias creating a decreased pressure at the delivery control connector female end fluid port (532), the decreased pressure withdrawing substantially all of the fluid on the surface on a surface of the delivery control connector female end fluid port (532) into the delivery control connector internal channel (510). 19. An apparatus (10) for the handling of a radiopharmaceutical fluid comprising; a) a collection vessel (100) containing a collection vessel volume (160), the collection vessel (100) further comprising: i) a collection vessel fluid port interlock (180), releasably attachable to a collection vessel connector (200); ii) a collection vessel internal channel (110) in fluid communication with the collection vessel volume (160) and in fluid communication with a collection vessel fluid port (170), being reversibly sealed from the environment by a collection vessel fluid port elastomeric closure (172) being biased in favor of being sealed; and b) the collection vessel connector (200) further comprising; i) a collection vessel connector male end fluid port interlock (224) releasably interlocking the collection vessel connector (200) to the collection vessel (100); ii) a collection vessel connector male end fluid port (222) in fluid communication with a collection vessel connector internal channel (210); iii) a connection vessel connector female end fluid port (232) in fluid communication with the collection vessel connector internal channel (210); iv) the collection vessel connector internal channel (210) containing a collection vessel connector deformable elastomeric valve (212) having a collection vessel connector deformable elastomeric valve male end (214) and a collection vessel connector deformable elastomeric valve female end (216); v) wherein the collection vessel connector deformable elastomeric valve female end (216) reversibly seals the collection vessel female end fluid port (232) from the collection vessel internal channel (210), and the collection vessel connector elastomeric valve female end (216) is biased in favor of being sealed; vi) a collection vessel connector female end fluid port interlock (234) releasably interlocking the collection vessel connector (200) to a first external device selected from the group of first external devices consisting of a unit dose container (300), a dose control connector (400), a delivery control connector (500), and a delivery site access device (600); c) the dose control connector (300) having; i) a dose control connector male end fluid port interlock (324) releasably interlocking the dose control connector (300) to a second external device selected from the group of second external devices consisting of the collection vessel connector (200), the delivery control connector (500), and the delivery site access device (600); ii) a dose control connector male end fluid port (322) in fluid communication with a dose control connector internal channel (310); iii) the dose control connector internal channel (310) containing a dose control connector deformable elastomeric valve (312) having a dose control connector deformable elastomeric valve male end (314) and a dose control connector deformable elastomeric valve female end (316); iv) wherein the dose control connector deformable elastomeric valve male end (312) reversibly seals the dose control male end fluid port (322) from the environment, the dose control connector elastomeric valve male end (312) being biased in favor of being sealed; v) a dose control female end fluid port (332) in fluid communication with the dose control connector internal channel (310); vi) a dose control connector female end fluid port interlock (334) releasably interlocking the dose control connector (300) to a third external device selected from the group of third external devices consisting of the unit dose container (400) and the delivery control connector (500); d) the unit dose container (400) containing a unit dose container volume (460), the unit dose container (400) further comprising; i) a unit dose container fluid port interlock (480) releasably interlocking the unit dose container (400) to a fourth external device selected from the group of fourth external devices consisting of the collection vessel connector (200), the dose control connector (300), the delivery control connector (500); and the delivery site access device (600); ii) a unit dose container internal channel (410) in fluid communication with the unit dose container volume (460) and in fluid communication with a unit dose container fluid port (470); iii) a unit dose container fluid manipulation regulator (490) regulating the unit dose container volume (460); e) the delivery control connector (500) having; i) a delivery control connector male end fluid port interlock (524) releasably interlocking the delivery control connector (500) to a fifth external device selected from the group of fifth external devices consisting of the collection vessel connector (200), the dose control connector (300), and the delivery site access device (600); ii) a delivery control connector male end fluid port (522) in fluid communication with a delivery control connector internal channel (510); iii) the delivery control connector internal channel (510) containing a delivery control connector deformable elastomeric valve (512) having a delivery control connector deformable elastomeric valve male end (514) and a delivery control connector deformable elastomeric valve female end (516); iv) a delivery control female end fluid port (532) in fluid communication with the delivery control connector internal channel (510); v) wherein the delivery control deformable elastomeric valve female end (516) reversibly seals the delivery control female end fluid port (532) from the environment, the delivery control connector elastomeric valve female end (516) being biased in favor of being sealed; vi) a delivery control connector female end fluid port interlock (534) releasably interlocking the delivery control connector (500) to a sixth external device selected from the group of sixth external devices consisting of the unit dose container (400) and the dose control connector (300); f) the delivery site access device (600) having; i) a delivery site access device fluid port (632) in fluid communication with a delivery site access device internal channel (610) and thence to a delivery site (S); ii) a delivery site interlock (630) releasably interlocking the delivery site connector to a seventh external device selected from the group of seventh external devices consisting of the unit dose container (400), the dose control connector (300), and the delivery control connector (500). 20. The apparatus (10) according to claim 19, wherein the dose control connector internal channel deformable elastomeric valve female end (316) reversibly seals the dose control female end fluid port (332) from the environment, the dose control connector elastomeric valve female end (316) being biased in favor of being sealed. 21. The apparatus (10) according to claim 19, wherein the delivery control connector deformable elastomeric valve male end (514) reversibly seals the delivery control male end fluid port (522) from the environment, the delivery control connector elastomeric valve male end (514) being biased in favor of being sealed. 22. The apparatus (10) according to claim 19, wherein the collection vessel fluid port elastomeric closure (172) further comprises a collection vessel fluid port puncturable resealable elastomeric seal (174). 23. The apparatus (10) according to claim 19, wherein the collection vessel connector male end fluid port (222) further comprises a collection vessel connector male end fluid port ingress regulator (223) capable of reversibly traversing the collection vessel fluid port puncturable resealable elastomeric seal (174) and thereby placing the collection vessel connector fluid port (222) in fluid communication with the collection vessel volume (160). 24. The apparatus (10) according to claim 19, wherein the collection vessel internal channel deformable elastomeric valve male end (214) is capable of sealing the collection vessel connector male end fluid port (222) from the environment, and the collection vessel internal channel deformable elastomeric valve male end (214) is biased in favor of being sealed. 25. The apparatus (10) according to claim 19, wherein the collection vessel fluid port interlock (180) further comprises a first interlock safety feature (555) capable of interlocking only with a cooperating second interlock safety feature (666) on the collection vessel connector (200). 26. The apparatus (10) according to claim 19, wherein the collection vessel connector female end fluid port interlock (234) further comprises a third interlock safety feature (777) capable of interlocking only with a cooperating fourth interlock safety feature (888). 27. The apparatus (10) according to claim 19, wherein the dose control connector female end fluid port interlock (434) further comprises a third interlock safety feature (777) capable of interlocking only with a cooperating fourth interlock safety feature (888). 28. The apparatus (10) according to claim 19, wherein the delivery control connector female end fluid port interlock (534) further comprises a third interlock safety feature (777) capable of interlocking only with a cooperating fourth interlock safety feature (888). 29. The apparatus (10) according to claim 19, wherein the delivery site access device interlock (630) further comprises a third interlock safety feature (777) capable of interlocking only with a cooperating fourth interlock safety feature (888). 30. The apparatus (10) according to claim 19, wherein the unit dose container fluid port interlock (480) further comprises a fourth interlock safety feature (888) capable of interlocking only with a cooperating third interlock safety feature (777). 31. The apparatus (10) according to claim 19, wherein the dose control connector male end fluid port interlock (324) further comprises a fourth interlock safety feature (888) capable of interlocking only with a mating third interlock safety feature (777). 32. The apparatus (10) according to claim 19, wherein the delivery control connector male end fluid port interlock (524) further comprises a fourth interlock safety feature (888) capable of interlocking only with a cooperating third interlock safety feature (777). 33. The apparatus (10) according to claim 19, wherein the delivery site access device interlock (630) further comprises a third interlock safety feature (777) capable of interlocking only with a mating fourth interlock safety feature (888). 34. The apparatus (10) according to claim 19, wherein the collection vessel (100), the collection vessel connector (200), the dose control connector (300), the unit does container (400), the delivery control connector (500), and the delivery site access device (600) are matched in coloration. 35. An apparatus (10) for the handling of a radiopharmaceutical fluid comprising; a) a collection vessel (100) containing a collection vessel volume (160), the collection vessel (100) further comprising: i) a collection vessel fluid port interlock (180), releasably attachable to a collection vessel connector (200); ii) a collection vessel internal channel (110) in fluid communication with the collection vessel volume (160) and in fluid communication with a collection vessel fluid port (170) reversibly sealed from the environment by a collection vessel fluid port elastomeric closure (172) being biased in favor of being sealed; b) the collection vessel connector (200) having a collection vessel male end (220) and a collection vessel female end (230) and further comprising; i) a collection vessel connector male end fluid port interlock (224) releasably interlocking the collection vessel connector (200) to the collection vessel (100); ii) a collection vessel connector male end fluid port (222) in fluid communication with a collection vessel connector internal channel (210); iii) a connection vessel connector female end fluid port (232) in fluid communication with the collection vessel connector internal channel (210); iv) the collection vessel connector internal channel (210) containing a collection vessel connector deformable elastomeric valve (212) having a collection vessel connector deformable elastomeric valve male end (214) and a collection vessel connector deformable elastomeric valve female end (216); v) wherein the collection vessel connector deformable elastomeric valve female end (216) reversibly seals the collection vessel female end fluid port (232) from the collection vessel internal channel (210), and the collection vessel connector elastomeric valve female end (216) is biased in favor of being sealed; vi) a collection vessel connector female end fluid port interlock (234) releasably interlocking the collection vessel connector (200) to a dose control connector (300); c) the dose control connector (300) having a dose control connector male end (320) and a dose control connector female end (330) and further comprising; i) a dose control connector male end fluid port interlock (324) releasably interlocking the dose control connector (300) to an eighth external device selected from the group of eighth external devices consisting of the collection vessel connector (200) and the delivery control connector (500); ii) a dose control connector male end fluid port (322) in fluid communication with a dose control connector internal channel (310); iii) the dose control connector internal channel (310) containing a dose control connector deformable elastomeric valve (312) having a dose control connector deformable elastomeric valve male end (314) and a dose control connector deformable elastomeric valve female end (316); iv) wherein the dose control connector deformable elastomeric valve male end (312) reversibly seals the dose control male end fluid port (322) from the environment, the dose control connector elastomeric valve male end (312) being biased in favor of being sealed; v) a dose control female end fluid port (332) in fluid communication with the dose control connector internal channel (310); vi) a dose control connector female end fluid port interlock (334) permanently interlocking the dose control connector (300) to the unit dose container fluid port interlock (480); d) the unit dose container (400) containing a unit dose container volume (460), the unit dose container (400) further comprising; i) a unit dose container fluid port interlock (480) permanently interlocking the unit dose container (400) to the dose control connector (300); ii) a unit dose container internal channel (410) in fluid communication with the unit dose container volume (460) and in fluid communication with a unit dose container fluid port (470); iii) a unit dose container fluid manipulation regulator (490) regulating the unit dose container volume (460); iv) a unit dose container fluid port interlock (480) permanently interlocking the unit dose container (400) to the dose control connector female end fluid port interlock (334); e) the delivery control connector (500) having a delivery control connector male end (520) and a delivery control connector female end (530) and further comprising; i) a delivery control connector male end fluid port interlock (524) permanently interlocking the delivery control connector (500) to the delivery site connector female end fluid port interlock (634); ii) a delivery control connector male end fluid port (522) in fluid communication with a delivery control connector internal channel (510); iii) the delivery control connector internal channel (510) containing a delivery control connector deformable elastomeric valve (512) having a delivery control connector deformable elastomeric valve male end (514) and a delivery control connector deformable elastomeric valve female end (516); iv) a delivery control female end fluid port (532) in fluid communication with the delivery control connector internal channel (510); v) wherein the delivery control deformable elastomeric valve female end (516) reversibly seals the delivery control female end fluid port (532) from the environment, the delivery control connector elastomeric valve female end (516) being biased in favor of being sealed; vi) a delivery control connector female end fluid port interlock (534) releasably interlocking the delivery control connector (500) the dose control connector (300); f) the delivery site access device (600) having a delivery site access device delivery site end (620) and a delivery site access device female end (630) and further comprises; i) a delivery site access device delivery site end (620) having delivery site connector delivery site end fluid port (622) in fluid communication with a delivery site access device internal channel (610); ii) a delivery site access device female end (630) having a delivery site access device female end fluid port (632) in fluid communication with the delivery site connector internal channel (610); and iii) a delivery site access device female end fluid port interlock (634) permanently interlocking the delivery site access device (600) to the delivery control connector male end fluid port interlock (524).