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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | UP-0077693 (2005-03-10) |
등록번호 | US-7713574 (2010-06-03) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 399 인용 특허 : 248 |
The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
What is claimed is: 1. A method for forming a plurality of non-planar analyte sensors, the method comprising: providing a non-planar continuous strand comprising an electrode material; coating a membrane system over the non-planar continuous strand by serially depositing a plurality of layers to fo
What is claimed is: 1. A method for forming a plurality of non-planar analyte sensors, the method comprising: providing a non-planar continuous strand comprising an electrode material; coating a membrane system over the non-planar continuous strand by serially depositing a plurality of layers to form the membrane system, wherein the membrane system comprises a membrane layer configured to control a flux of an analyte and an enzyme domain layer comprising an enzyme for reacting with the analyte, and wherein the membrane system is coated over the non-planar continuous strand by a continuous process; and cutting the non-planar continuous strand to form a plurality of non-planar analyte sensors. 2. The method of claim 1, wherein the step of coating comprises serially depositing a plurality of membrane layers to form the membrane system, wherein the membrane system has a thickness of from about 1 micron to about 15 microns. 3. The method of claim 1, wherein the step of coating comprises coating a bioprotective domain configured to protect one or more electrodes from a biological environment. 4. The method of claim 1, wherein the step of coating comprises coating an electrode domain configured to provide hydrophilicity at one or more electrodes. 5. The method of claim 1, wherein the step of coating comprises coating a resistance domain configured to control a flux of the analyte. 6. The method of claim 1, wherein the step of coating comprises coating an interference domain configured to block or resist passage therethrough of one or more interferents. 7. The method of claim 1, further comprising drying or curing the membrane system. 8. The method of claim 1, wherein the step of coating is conducted substantially without human interaction. 9. The method of claim 1, wherein the plurality of non-planar sensors are configured for substantially continuous analyte measurement in a biological environment. 10. The method of claim 9, wherein the plurality of non-planar sensors are configured for substantially continuous measurement of glucose in a host. 11. The method of claim 1, wherein the non-planar continuous strand comprises a wire. 12. The method of claim 11, wherein the wire has a diameter of less than about 0.010 inches. 13. The method of claim 1, wherein the non-planar continuous strand comprises at least two non-planar electrode materials. 14. The method of claim 13, wherein the at least two non-planar electrode materials are coaxially formed. 15. The method of claim 13, wherein the at least two non-planar electrode materials are twisted wires. 16. The method of claim 1, wherein the continuous process is a continuous reel-to-reel process. 17. The method of claim 1, wherein the non-planar continuous strand comprises a working electrode and a reference electrode. 18. The method of claim 17, wherein the non-planar strand further comprises an insulator located between the working electrode and the reference electrode. 19. The method of claim 1, wherein at least a portion of membrane system is exposed on an outer surface of the non-planar continuous strand during the cutting. 20. The method of claim 1, wherein the membrane system comprises a plurality of membrane domains. 21. The method of claim 1, wherein the non-planar continuous strand comprises an inner electrode and an insulating layer. 22. The method of claim 21, further comprising removing a portion of the insulating layer prior to coating, wherein removing a portion of the insulating layer exposes a surface of the inner electrode. 23. The method of claim 22, wherein the coating is over the exposed surface of the inner electrode. 24. The method of claim 1, wherein the non-planar continuous strand comprises an inner electrode core, an insulating layer and outer electrode layer. 25. The method of claim 24, further comprising removing a portion of the outer electrode core and the insulating layer prior to coating, wherein removing a portion of the outer electrode core and the insulating layer exposes a surface of the inner electrode core. 26. The method of claim 25, wherein the coating is over the exposed surface of the inner electrode core. 27. The method of claim 1, wherein the non-planar continuous strand comprises a working electrode formed from a core of a first metal and an outer layer of a second metal. 28. The method of claim 27, wherein the coating is over the working electrode.
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