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다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | UP-0335240 (2002-12-31) |
등록번호 | US-7717863 (2010-06-10) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 2 인용 특허 : 1030 |
A tissue penetration device includes a penetrating member driver and a cartridge. A plurality of penetrating members are integrated with the cartridge. Each penetrating member is coupled to the penetrating member driver when advanced along a path into a tissue target. A penetrating member sensor is
A tissue penetration device includes a penetrating member driver and a cartridge. A plurality of penetrating members are integrated with the cartridge. Each penetrating member is coupled to the penetrating member driver when advanced along a path into a tissue target. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configured to provide information relative to a depth of penetration of a penetrating member through a skin surface.
What is claimed is: 1. A tissue penetration device, comprising: a penetrating member driver; a cartridge; a plurality of penetrating members integrated with the cartridge, each of penetrating member coupled to the penetrating member driver when advanced along a path into a tissue target; and a pene
What is claimed is: 1. A tissue penetration device, comprising: a penetrating member driver; a cartridge; a plurality of penetrating members integrated with the cartridge, each of penetrating member coupled to the penetrating member driver when advanced along a path into a tissue target; and a penetrating member position sensor coupled to a processor, the processor including a memory that includes stored information of (i) a distance of a penetrating member tip from a target tissue, (ii) acceleration and displacement of the penetrating member; and (iii) a start position of the penetrating member, the processor using the stored information to calculate depth of penetration of the penetrating member and a feedback loop coupled to the penetrating member position sensor. 2. The system of claim 1, wherein the depth of penetration is 100 to 2500 microns. 3. The system of claim 1, wherein the depth of penetration is 500 to 750 microns. 4. The system of claim 1, wherein the penetrating member sensor is further configured to provide an indication of velocity of a penetrating member. 5. The system of claim 1, further comprising: a second penetrating member sensor configured to provide an indication of velocity of a penetrating member. 6. The system of claim 1, wherein the penetrating member driver is an electric drive force member. 7. The system of claim 1, wherein the penetrating member driver is a voice coil drive force generator. 8. The system of claim 1, wherein the processor includes a memory for storage and retrieval of a set of penetrating member profiles utilized with the penetrating member driver. 9. The system of claim 8, wherein the processor is utilized to control a withdraw force to the penetrating member so that the penetrating member moves in a second direction away from the target tissue. 10. The system of claim 9, wherein in a first direction the penetrating member moves toward the target tissue at a speed that is different than a speed at which the penetrating member moves away from the target tissue. 11. The system of claim 10, wherein in the first direction the penetrating member moves toward the target tissue at a speed that is greater than a speed at which the penetrating member moves away from the target tissue. 12. The system of claim 10, wherein a speed of a penetrating member in the first direction is the range of 0.05 to 60 m/sec. 13. The system of claim 10, wherein a speed of a penetrating member in the first direction is the range of 0.1 to 20.0 m/sec. 14. The system of claim 10, wherein a speed of a penetrating member in the first direction is the range of 1.0 to 10.0 m/sec. 15. The system of claim 10, wherein a speed of a penetrating member in the first direction is the range of 3.0 to 8.0 m/sec. 16. The system of claim 10, wherein a dwell time of the penetrating member in the target tissue below a skin surface is in the range of 1 microsecond to 2 seconds. 17. The system of claim 1, wherein a dwell time of the penetrating member in the target tissue below a skin surface is in the range of 500 milliseconds to 1.5 second. 18. The system of claim 1, wherein a dwell time of the penetrating member in the target tissue below a skin surface is in the range of 100 milliseconds to 1 second. 19. The system of claim 1, further comprising: a plurality of cartridges integrated in a cassette. 20. The system of claim 19, wherein each cartridge has an exit port, and upon launch each penetrating member exists from the exit port. 21. The system of claim 1, wherein the penetrating member sensor includes an optical encoder. 22. The system of claim 1, further comprising: an analyte detecting member. 23. The system of claim 1, further comprising: a plurality of analyte detecting members each coupled to a penetrating member. 24. The system of claim 1, further comprising: a sample chamber with an opening for transport of a body fluid into the sample chamber, the sample chamber being sized to receive no more than 1.0 μL of the body fluid. 25. The system of claim 24, wherein each of a penetrating member and an associated sample chamber have a combined packing density of no more than 1.0 cm3. 26. The system of claim 24, wherein each of a penetrating member and an associated sample chamber have a combined packing density of no more than 0.75 cm3. 27. The system of claim 24, wherein each of a penetrating member and an associated sample chamber have a combined packing density of no more than 0.5 cm3. 28. The system of claim 24, wherein each of a penetrating member and an associated sample chamber have a combined packing density of no more than 0.25 cm3. 29. The system of claim 24, wherein each of a penetrating member and an associated sample chamber have a combined packing density of no more than 0.1 cm3. 30. The system of claim 1, further comprising: a sample chamber with an opening for transport of a body fluid into the sample chamber, the sample chamber being sized to receive no more than 0.75 μL of the body fluid. 31. The system of claim 1, further comprising: a sample chamber with an opening for transport of a body fluid into the sample chamber, the sample chamber being sized to receive no more than 0.5 μL of the body fluid. 32. The system of claim 1, further comprising: a sample chamber with an opening for transport of a body fluid into the sample chamber, the sample chamber being sized to receive no more than 0.25 μL of the body fluid. 33. The system of claim 1, further comprising: a sample chamber with an opening for transport of a body fluid into the sample chamber, the sample chamber being sized to receive no more than 0.1 μL of the body fluid. 34. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 1 μL of a body fluid disposed in the sample chamber. 35. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 0.75 μL of a body fluid disposed in the sample chamber. 36. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 0.5 μL of a body fluid disposed in the sample chamber. 37. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 0.25 μL of a body fluid disposed in the sample chamber. 38. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 0.1 μL of a body fluid disposed in the sample chamber. 39. The system of claim 1, wherein each of a penetrating of the plurality of penetrating members has a packing density of no more than 1.0 cm3/penetrating member. 40. The system of claim 1, wherein each of a penetrating member of the plurality of penetrating members has a packing density of no more than 0.5 cm3/penetrating member. 41. The system of claim 1, wherein the each of a penetrating member of the plurality of penetrating members has a packing density of no more than 0.5 cm3/penetrating member. 42. The system of claim 1, wherein each of a penetrating member of the plurality of penetrating members has a packing density of no more than 0.25 cm3/penetrating member. 43. The system of claim 1, where in each of a penetrating member of the plurality of penetrating members has a packing density of no more than 0.1 cm3/penetrating member. 44. The system of claim 1, further comprising: a first seal formed by a fracturable material between the penetrating member and the cartridge, the first seal being positioned at least one of a distal port or a proximal port of the cartridge 45. The system of claim 44, further comprising a second fracturable seal located at least one of the distal port or proximal port of cartridge. 46. The system of claim 1, wherein each penetrating member is an elongate member without molded attachments. 47. The system of claim 1, further comprising: a penetrating member transport device for moving each of a penetrating member into a position aligned with the penetrating member driver. 48. The system of claim 1, further comprising, a belt for holding the penetrating members in an array configuration. 49. The system of claim 1, further comprising: a tape device configured to hold the penetrating members in an array configuration. 50. The system of claim 1, further comprising: a support channel configured to hold the penetrating members in an array configuration. 51. The system of claim 1, further comprising: a cog configured to hold the penetrating members in an array configuration. 52. The system of claim 1, further comprising: a plurality of connectors between penetrating members for holding the penetrating members in an array configuration. 53. The system of claim 1, further comprising: a support structure for receiving the penetrating members.
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