A system, including catheter apparatus, and related method for performing site specific therapy. The catheter apparatus can include one or more semipermeable microcatheters for use in performing site specific microdialysis. The system and method are particularly suited for use in addressing cerebral
A system, including catheter apparatus, and related method for performing site specific therapy. The catheter apparatus can include one or more semipermeable microcatheters for use in performing site specific microdialysis. The system and method are particularly suited for use in addressing cerebral edema by affecting the osmolar relationship between fluids making up the brain tissue. Also disclosed is an apparatus having a delivery/recovery mechanism in the form of a pump reservoir and one or more catheters in the form of semipermeable microcatheters, for use in delivering and/or recovering fluid to and/or from a tissue site or for performing tissue engineering outside of the body. The apparatus can be used in a method to perform site specific microtherapy, including for the treatment of avascular necrosis, compartment syndrome, cerebral edema, and to improve skin flap survival in the course of reconstructive surgery.
대표청구항▼
What is claimed is: 1. An apparatus for performing site specific tissue therapy, the apparatus comprising: (a) one or more semipermeable microcatheters adapted to be positioned within the tissue site, and (b) a delivery and/or recovery mechanism for employing the microcatheter(s) to control the mov
What is claimed is: 1. An apparatus for performing site specific tissue therapy, the apparatus comprising: (a) one or more semipermeable microcatheters adapted to be positioned within the tissue site, and (b) a delivery and/or recovery mechanism for employing the microcatheter(s) to control the movement of bulk fluids and/or active fluid components within or between tissue portions or adjacent tissues in a manner that achieves a therapeutic effect, wherein at least one of the one or more microcatheters consists essentially of a central guidewire positioned within the microcatheter to facilitate its placement, the microcatheter and guidewire being bound together at their distal ends. 2. An apparatus according to claim 1 wherein the microcatheter with central guidewire comprises a single lumen for the flow of fluid therein. 3. An apparatus according to claim 2 wherein the microcatheter is provided in the form of a capillary having an outer diameter of less than about one centimeter. 4. An apparatus according to claim 3 wherein the diameter is less than about three millimeters. 5. An apparatus according to claim 1 wherein the microcatheter with central guidewire is adapted for use as a container to effect the controlled release of materials from the fiber. 6. An apparatus according to claim 1 wherein the microcatheter with central guidewire is adapted for use as a reactor to chemically modify a permeant as it diffuses through a chemically activated wall. 7. An apparatus according to claim 1 wherein the microcatheter with central guidewire is either open to the permeation of gas or liquid through its wall, while flow of the lumen medium is not restricted, or the microcatheter wall is loaded such that the lumen is itself filled with an immobilized solid or liquid. 8. An apparatus according to claim 1 wherein the microcatheter with central guidewire is formed of a material selected from the group consisting of isotropic and anisotropic materials. 9. A system for performing site specific tissue therapy, the system comprising an apparatus according to claim 1, wherein the system comprises the microcatheter with central guidewire in fluid communication with one or more pump reservoirs for the delivery and/or recovery of fluid and/or fluid components. 10. A system according to claim 9 wherein the tissue site comprises impaired interstitial circulation, and the system is adapted to recover water and permeant solutes from the tissue site. 11. A system according to claim 9 wherein the tissue site comprises a solid tumor. 12. A system according to claim 9 wherein the fluid movement is used to effect the movement of biologically active molecules within the tissue site. 13. A system according to claim 9 wherein the apparatus is used for the deliberate and controlled movement of fluids and/or the active fluid components, within or between tissue portions or adjacent tissues. 14. A system according to claim 9 wherein the system is used for the infusion of therapeutic agents and the corresponding removal of tissue fluids. 15. A system according to claim 9, wherein the system is used to deliver toxic agents directly to a tissue site. 16. A system according to claim 9, wherein the system is used for the delivery of poorly diffusible molecules to the interstitum. 17. A system according to claim 9, wherein the apparatus is used to treat inflammation in a fixed tissue space. 18. A system according to claim 9 wherein the system is adapted for tissues having an inadequate local tissue microcirculatory system to perfuse the tissue. 19. An apparatus according to claim 1 wherein the tissue site exhibits impaired interstitial circulation, and the system is adapted to recover water and permeant solutes from the tissue site. 20. An apparatus according to claim 1 wherein the tissue site comprises a solid tumor. 21. An apparatus according to claim 1 wherein the fluid movement is used to effect the movement of biologically active molecules. 22. An apparatus according to claim 1 wherein the apparatus is used for the deliberate and controlled movement of fluids and/or the active fluid components, within or between tissue portions or adjacent tissues. 23. An apparatus according to claim 1 wherein the system is used for the infusion of therapeutic agents and the corresponding removal of tissue fluids. 24. An apparatus according to claim 1, wherein the system is used to deliver toxic agents directly to a tissue site. 25. An apparatus according to claim 1, wherein the system is used for the delivery of poorly diffusible molecules to the interstitum. 26. An apparatus according to claim 1, wherein the apparatus is used to treat inflammation in a fixed tissue space. 27. An apparatus according to claim 1 wherein the system is adapted for tissues having an inadequate local tissue microcirculatory system to perfuse the tissue. 28. A system according to claim 9 wherein the microcatheter comprises a single lumen for the flow of fluid therein. 29. A system according to claim 9 wherein the microcatheter with central guidewire has an outer diameter of less than about one centimeter. 30. A system according to claim 29 wherein the diameter is less than about three millimeters. 31. A system according to claim 9 wherein the microcatheter with central guidewire is formed of a material selected from the group consisting of isotropic and anisotropic materials. 32. An apparatus according to claim 1 wherein the microcatheter with central guidewire is adapted to deliver and/or recover fluid and/or solutes from the tissue site. 33. An apparatus according to claim 32 wherein such delivery/recovery is provided by means selected from the group consisting of osmolar forces, hydrostatic pressure, diffusion, and combinations thereof. 34. An apparatus according to claim 33 wherein the microcatheter comprises a single lumen and has an outer diameter of less than about one centimeter. 35. An apparatus according to claim 34 wherein the system is adapted for a therapeutic application selected from the group consisting of the infusion of therapeutic agents, the delivery of toxic agents directly to a tissue site, the delivery of poorly diffusible molecules to the tissue interstitium, and the treatment of inflammation in a fixed tissue space. 36. An apparatus for performing site specific tissue therapy, the apparatus comprising: (a) one or more semipermeable microcatheters adapted to be positioned within the tissue site, and (b) a delivery and/or recovery mechanism for employing the microcatheter(s) to control the movement of bulk fluids and/or active fluid components within or between tissue portions or adjacent tissues in a manner that achieves a therapeutic effect, wherein at least one of the one or more microcatheters consists essentially of a central guidewire to facilitate its placement, the microcatheter and guidewire being bound together at their distal ends, and wherein the microcatheter with central guidewire comprises a single lumen for the flow of fluid therein. 37. An apparatus according to claim 36 wherein the microcatheter is provided in the form of a capillary having an outer diameter of less than about three millimeters. 38. An apparatus according to claim 37 wherein the microcatheter comprises a single lumen and has an outer diameter of less than about one centimeter. 39. An apparatus according to claim 38 wherein the system is adapted for a therapeutic application selected from the group consisting of the infusion of therapeutic agents, the delivery of toxic agents directly to a tissue site, the delivery of poorly diffusible molecules to the tissue interstitium, and the treatment of inflammation in a fixed tissue space.
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