[특허]Bone growth particles and osteoinductive composition thereof

Bone growth particles and osteoinductive composition thereof 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-008/65 C07K-014/78
출원번호	UP-0614422 (2006-12-21)
등록번호	US-7718616 (2010-06-10)
발명자 / 주소	Thorne, Kevin J.
출원인 / 주소	Zimmer Orthobiologics, Inc.
대리인 / 주소	Howrey LLP
인용정보	피인용 횟수 : 12 인용 특허 : 162

초록 ▼

A biocompatible synthetic bone growth composition comprising a fibrillar collagen component and a calcium phosphate component. The composition is formed into particles, and then formed into a unitary article that may be provided at the site of a skeletal defect. An osteoinductive component may be further added, either before or after forming the unitary article. The composition may be formulated as a paste or putty and facilitates bone growth and/or repair.

대표청구항 ▼

What is claimed is: 1. A process for producing a bone growth composition comprising combining a fibrillar collagen component with an acidic calcium phosphate component to produce a mineralized collagen component, and creating particles of the mineralized collagen component, wherein the mineralized collagen component comprises the form of a crosslinked sponge prior to creating the particles, wherein creation of the particles includes milling. 2. The process of claim 1 wherein the mineralized collagen component comprises the form of a gel prior to creating the particles. 3. The process of claim 1 comprising adding an osteoinductive component to the composition. 4. The process of claim 3 wherein the osteoinductive component is added after the particles are formed. 5. The process of claim 1 wherein combining a fibrillar collagen component with an acidic calcium phosphate component to produce a mineralized collagen component further comprises preparing a collagen gel. 6. The composition of claim 5 further comprising lyophilizing the mineralized collagen compomnent. 7. The process of claim 1 wherein the acidic calcium phosphate is selected from the group consisting of monocalcium phosphate [Ca(H2PO4)2], calcium phosphate dibasic [CaHPO4], calcium pyrophosphate [2CaO.P2O5], and combinations thereof. 8. The process of claim 7 wherein the acidic calcium phosphate comprises calcium phosphate dibasic [CaHPO4]. 9. The process of claim 1 wherein collagen is dehydrothermally crosslinked. 10. A process for producing a bone growth composition comprising combining a fibrillar collagen component with an acidic calcium phosphate component to produce a mineralized collagen component, and creating particles of the mineralized collagen component, wherein the mineralized collagen component comprises the form of a crosslinked sponge prior to creating the particles, further comprising including the particles in a kit. 11. The process of claim 10 wherein the kit includes a device for mixing the particles with a fluid. 12. The process of claim 10 wherein the kit includes a receptacle for mixing the particles with a fluid. 13. A process for producing a bone growth composition comprising combining a fibrillar collagen component with an acidic calcium phosphate component to produce a mineralized collagen component, and creating particles of the mineralized collagen component, wherein the mineralized collagen component comprises the form of a crosslinked sponge prior to creating the particles, further comprising sizing the particles. 14. The process of claim 13 wherein the size of the particles is selected by sieving.

이 특허에 인용된 특허 (162)

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Thangavel Kuberasampath ; Lawrence Berlowitz Tarrant, Synthetic bone matrix.
상세보기
Ammann Arthur J. (460 Point San Bruno Blvd. South San Francisco CA 94080-4990) Beck Steven L. (460 Point San Bruno Blvd. South San Francisco CA 94080-4990) Nguyen Tue H. (460 Point San Bruno Blvd. So, TGF-b 상세보기

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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Bone growth particles and osteoinductive composition thereof 원문보기

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Bone growth particles and osteoinductive composition thereof 원문보기

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전체(0) 논문(0) 특허(0) 보고서(0)

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이 특허를 인용한 특허 (12)

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