IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0467330
(2002-01-18)
|
등록번호 |
US-7727474
(2010-06-22)
|
우선권정보 |
DE-101 05 753(2001-02-08) |
국제출원번호 |
PCT/EP2002/000463
(2002-01-18)
|
§371/§102 date |
20030806
(20030806)
|
국제공개번호 |
WO02/062474
(2002-08-15)
|
발명자
/ 주소 |
|
출원인 / 주소 |
- Merck Patent Gesellschaft mit beschrankter Haftung
|
대리인 / 주소 |
Millen, White, Zelano & Branigan, P.C.
|
인용정보 |
피인용 횟수 :
2 인용 특허 :
9 |
초록
▼
The invention relates to a closure for a reagent container (7) with a screw-cap or lid (6), comprising a conical insert (4), reaching in the direction of the contents. The conical insert (4) is cut at least once, such that said insert may be bent apart in the lower region thereof and further compris
The invention relates to a closure for a reagent container (7) with a screw-cap or lid (6), comprising a conical insert (4), reaching in the direction of the contents. The conical insert (4) is cut at least once, such that said insert may be bent apart in the lower region thereof and further comprises, for example, an annular step (3) in the middle region thereof. In the rest state the cone completely seals the reagent container. For the removal of liquid, a pipette with a release sleeve (2), in other words, a broadening (2) at a particular separation from the needle end (1), is introduced. The release sleeve contacts the step of the conical insert (3) and produces a separation of the divided walls of the cone. The pipette needle enters the container without making contact with the cone, in other words with the closure. As the pipette needle, complete with release sleeve (2), is withdrawn, the walls of the cone close back together, as the release sleeve (2) is no longer pressing on the step (3).
대표청구항
▼
The invention claimed is: 1. A pipetting arrangement comprised of a pipette, a closure and a container, the pipetting arrangement providing for withdrawal of liquids from a reagent container (7), wherein the pipetting arrangement comprises a pipette (1) having an actuator sleeve (2) positioned arou
The invention claimed is: 1. A pipetting arrangement comprised of a pipette, a closure and a container, the pipetting arrangement providing for withdrawal of liquids from a reagent container (7), wherein the pipetting arrangement comprises a pipette (1) having an actuator sleeve (2) positioned around and permanently attached to the pipette (1), the actuator sleeve (2) being axially spaced from an insertion end (5) of the pipette (1) and wherein a closure for the reagent container (7) is accessible by said pipette (1) and has an insertion end (5) consisting of a cap part (6) for attachment to the reagent container (7) and a conical insert (4), wherein the conical insert (4) is incorporated into an opening of the cap part (6) and has a conical or pyramidal wall which terminates in a entrance point (10) in the direction of the reagent container (7) in that the conical or pyramidal wall of the conical insert (4) is divided into flaps (11) by at least one cut (12) and has an actuation ridge (3) on a side facing away from the reagent container (7), the actuation ridge (3) having a diameter defining an opening larger than the diameter of the pipette (1) and smaller than the diameter of the actuator (2) on the pipette (1), wherein the pipette (1) need not engage the conical insert (4) to enter the reagent container (7) because the actuator (2) engages the flaps (11) to deflect the flaps away from the pipette (1), and wherein the flaps (11) close upon withdrawal of the actuator (2) from the ridge (3) after the pipette (1) leaves the entrance point (10) of the conical insert (4), wherein when the pipette (1) is withdrawn together with the actuation sleeve (2), walls of the conical insert (4) reclose since the actuating sleeve (2) no longer forces the actuation ridge (3) apart again tightly sealing the reaction container (7), which prevents contamination of contents in the reaction container (7) during withdrawal of the pipette (1). 2. A pipetting arrangement according to claim 1 wherein there is at least one pipette is configured as a pipetting needle (1). 3. The pipetting arrangement according to claim 1 wherein the conical insert (4) is provided on the side facing the reagent container (7) with pressure springs, elastic bands or an elastic membrane. 4. A pipetting arrangement according to claim 3 wherein there is at least one pipette configured as a pipetting needle (1), the pipetting arrangement being in combination with at least one reagent container (7). 5. A method for the withdrawal of liquids from or dispensing liquids into a reagent container utilizing the pipetting arrangement of claim 1, comprising: a) providing the reagent container (7) sealed with the closure (C) and using the pipette (1); b) inserting vertically the pipette (1) into the center of the conical insert (4) of the closure (C) until the insertion end (5) of the pipette (1) dips into liquid within the reagent container, with the flaps on the actuation ridge (30) of the conical insert (4) being pushed outward by the actuator (2) by engagement with an actuation ridge (3) so that the pipette (1) does not touch the conical insert (4); c) drawing-off the liquid in the reagent container by drawing the liquid through the pipette (1) or dispensing a liquid from the pipette into the reagent container (7), and d) vertically withdrawing the pipette (1), during which the flaps (11) of the conical insert (4) close tightly as soon as the actuator (2) no longer pushes the flaps (11) outward. 6. A pipetting method according to claim 5 wherein there is at least one pipette configured as a pipetting needle (1), the pipetting arrangement being in combination with at least one reagent container (7). 7. A method for the withdrawal of liquids from or dispensing liquids into a reagent container utilizing the pipetting arrangement of claim 3, comprising: a) providing the reagent container (7) sealed with the closure (C) and using the pipette (1); b) inserting vertically the pipette (1) into the center of the conical insert (4) of the closure (C) until the insertion end (5) of the pipette (1) dips into liquid within the reagent container, with the flaps (11) on the actuation ridge (3) of the conical insert (4) being pushed outward by the actuator (2) so that the pipette (1) does not touch the conical insert (4); c) drawing-off the liquid in the reagent container by drawing the liquid through the pipette (1) or dispensing a liquid from the pipette (1) into the reagent container (7), and d) vertically withdrawing the pipette (1), during which the flaps (11) of the conical insert (4) close tightly as soon as the actuator (2) no longer pushes the flaps (11) outward.
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