초록 ▼

A device and a process for testing a sample liquid in which especially the ELISA process can be carried out very easily, rapidly and with high precision. To do this, a sample liquid and a dilution liquid are each supplied to several metering chambers of different volumes, so that the sample liquid c

A device and a process for testing a sample liquid in which especially the ELISA process can be carried out very easily, rapidly and with high precision. To do this, a sample liquid and a dilution liquid are each supplied to several metering chambers of different volumes, so that the sample liquid can be diluted into assigned reaction chambers in one dilution step in different dilution ratios. Different liquids can be supplied in succession to the reaction chambers by means of a common receiving chamber. The liquids are transferred from the reaction chambers into the assigned test chambers to stop the detection reaction.

대표청구항 ▼

The invention claimed is: 1. Device for testing a sample liquid, comprising: a first common receiving chamber means for receiving the sample liquid, a plurality of first metering chamber means for holding the sample liquid which are connected to the first receiving chamber means, at least one secon

The invention claimed is: 1. Device for testing a sample liquid, comprising: a first common receiving chamber means for receiving the sample liquid, a plurality of first metering chamber means for holding the sample liquid which are connected to the first receiving chamber means, at least one second common receiving chamber means for holding a dilution liquid arranged parallel to said first common receiving chamber means, a plurality of second metering chambers means for exclusive metering of dilution liquid received from the second receiving chamber means, a plurality of reaction chambers, each of which is connected separately to said first and second metering chambers means wherein at least one of the first and second metering chamber means vary in their volumes, wherein at least one of the first and second metering chamber means are assigned to one another in parallel pairs, each pair being connected to an assigned reaction chamber so that the volumes of the sample liquid and dilution liquid which are contained in the first and second metering chamber means are transferred in separate parallel paths into the assigned reaction chambers and mixed, by which the sample liquid can be diluted with different dilution ratios. 2. Device as claimed in claim 1, wherein the volumes of the first metering chamber means, proceeding from the first receiving chamber means, increase or decrease and the volumes of the second metering chamber means decrease or increase oppositely to the volumes of the assigned first metering chamber means. 3. Device as claimed in claim 1, wherein the sums of the volumes of the first and second metering chamber means assigned to one another in pairs are the same. 4. Device as claimed in claim 1, wherein at least one of the reaction chambers is connected to a further chamber in which the diluted sample liquid in it is deliverable for further dilution. 5. Device as claimed in claim 1, wherein the first metering chamber means are connected in parallel to the first common receiving chamber means for receiving the sample liquid. 6. Device as claimed in claim 1, wherein the second metering chamber means are connected in parallel to the second common receiving chamber means for receiving the dilution liquid. 7. Device as claimed in claim 1, wherein every other metering chamber means is connected to an assigned reaction chamber via a connection and each assigned first metering chamber means is connected in parallel to the assigned reaction chamber via a liquid stop. 8. Device as claimed in claim 7, wherein the second metering chamber means and the assigned reaction chamber are arranged so that dilution liquid transferred between them will wet the liquid stop of the assigned first metering chamber means on an outflow side to support transfer of the sample liquid out of the first metering chamber means into the assigned reaction chamber. 9. Device as claimed in claim 1, wherein additional first metering chamber means for receiving diluted sample liquid are connected to at least one of the reaction chambers, and wherein additional second metering chamber means for receiving the dilution liquid are connected to at least one the second receiving chamber means, a collecting chamber assigned to the second metering chamber means for dilution liquid, and an additional supply of dilution liquid; wherein at least one of the additional first metering chamber means and the second metering chamber means vary in their volumes, wherein the additional first and second metering chamber means are assigned to one another in pairs, and wherein each of the pairs of additional first and second metering chamber means is connected to an assigned additional reaction chamber so that the volumes of the already once diluted sample liquid and dilution liquid which are contained in the additional first and second metering chamber means can be transferred in pairs into the assigned additional reaction chamber and mixed, by which the already once diluted sample liquid can be further diluted with different dilution ratios. 10. Device as claimed in claim 9, wherein the volumes of the additional first metering chamber means and the volumes of the additional second metering chamber means vary oppositely to the volumes of the assigned additional metering chambers. 11. Device as claimed in claim 10, wherein the sums of the volumes of the additional first and second metering chamber means assigned respectively in pairs are the same. 12. Device as claimed in claim 1, further comprising a third receiving chamber means for receiving of at least one of a liquid with a reagent, an antibody, a washing liquid, and a blocking liquid. 13. Device as claimed in claim 1, further-comprising means for emptying the first receiving chamber means each time before a sample liquid is received again. 14. Device as claimed in claim 13, wherein at least two reaction chamber means are connected to the liquid receiving chamber means in a manner producing sequential reception of liquid by one of pressure, capillary and centrifugal forces. 15. Device as claimed in claim 14, wherein at least several of the reaction chamber means are connected to the liquid receiving chamber means in a manner enabling sequential reception of liquid(s) by pressure, capillary and/or centrifugal forces. 16. Device as claimed in claim 1, further comprising test chambers which are assigned to at least the reaction chambers and which form a means for stopping detection reactions which proceed in the reaction chambers by the liquids located in the reaction chambers being transferable thereto. 17. Device as claimed in claim 13, wherein the device has test chambers assigned to at least the reaction chamber means, said test chambers forming a means for stopping detection reactions which proceed in the reaction chamber means by the liquids located in the reaction chambers being transferable into the assigned test chambers.