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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | UP-0159752 (2005-06-23) |
등록번호 | US-7740623 (2010-07-12) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 21 인용 특허 : 608 |
The current invention discloses a method for treating infracted/ischemic injury to a myocardium by injecting a substance into the myocardium. The injected substance helps to prevent negative adaptive remodeling by providing mechanical reinforcement or mechanical reinforcement combined with biologica
The current invention discloses a method for treating infracted/ischemic injury to a myocardium by injecting a substance into the myocardium. The injected substance helps to prevent negative adaptive remodeling by providing mechanical reinforcement or mechanical reinforcement combined with biological therapy. A number of substances for injection are disclosed, including multi component substances such as platelet gel, and other substances. The substances disclosed may contain additives to augment/enhance the desired effects of the injection. The invention also discloses devices used to inject the substances. The devices can include means for ensuring needles do not penetrate beyond a desired depth into the myocardium. The devices can also include needles having multiple lumens such that the components of the platelet gel will be combined at the injection site and begin polymerization in the myocardium.
The invention claimed is: 1. A method to treat negative remodeling comprising: providing an injection device fluidly coupled to a source of platelet plasma and a source of thrombin, wherein the device includes a first needle for separately injecting platelet plasma into tissue and a second needle f
The invention claimed is: 1. A method to treat negative remodeling comprising: providing an injection device fluidly coupled to a source of platelet plasma and a source of thrombin, wherein the device includes a first needle for separately injecting platelet plasma into tissue and a second needle for separately injecting thrombin into tissue; advancing the first and second needles of the injection device through an opening in a patient to the patient's heart; identifying the location, size and shape of ischemic tissue in the heart by the use of one or more sensors; driving the first and second needles of the injection device into the ischemic tissue; and injecting the platelet plasma and the thrombin separately into the ischemic tissue, wherein the platelet plasma and the thrombin combine within the ischemic tissue to form a platelet gel to provide mechanical reinforcement to the heart. 2. The method as in claim 1, wherein the opening is an intercostal opening. 3. The method as in claim 1, wherein the opening is a xiphoid opening below the sternum. 4. The method as in claim 1, wherein the opening is a sternotomy. 5. The method as in claim 1, wherein the opening is a percutaneous opening. 6. A method as in claim 1, wherein the platelet plasma is autologous. 7. A method as in claim 1, wherein the platelet plasma is non-autologous. 8. A method as in claim 1, wherein the thrombin is autologous. 9. A method as in claim 1, wherein the thrombin is non-autologous. 10. A method as in claim 1, wherein the platelet plasma is platelet rich plasma. 11. A method as in claim 1, wherein the platelet plasma is platelet poor plasma. 12. A method as in claim 1, wherein the injecting occurs between contractions of the heart. 13. A method as in claim 1, wherein the heart is temporarily stopped using vagal nerve stimulation. 14. A method as in claim 1, further comprising: providing a positioning device; engaging the heart with the positioning device; and positioning the heart into a non-physiological orientation. 15. A method as in claim 14, wherein the injecting occurs following the positioning of the heart in a non-physiological orientation step. 16. A method as in claim 1, wherein the injecting step occurs following a myocardial infarction. 17. A method as in claim 1, wherein the first and second needles each include a sharp distal end and at least one discharge port. 18. A method as in claim 17, wherein the injection device further includes: a suction member for grasping an area of tissue; an elongate shaft having a longitudinal axis, a proximal region and a distal region, the distal region coupled to the suction member and operably coupled to the first and second needles; and a mechanism for driving the sharp distal ends of the first and second needles into the area of tissue grasped by the suction member. 19. A method as in claim 18, wherein the injection device includes a mechanism for controllably varying the needle penetration depth of the first and second needles into the tissue. 20. A method as in claim 18, wherein the suction member includes one or more sensors. 21. A method as in claim 17, wherein the first and second needles each include a distal discharge port. 22. A method as in claim 17, wherein the first and second needles each include a discharge port proximal the sharp distal end of the first and second needles. 23. A method as in claim 1, wherein the platelet plasma and the thrombin are injected multiple times into the ischemic tissue. 24. A method as in claim 23, wherein each injection of the platelet plasma and the thrombin into the ischemic tissue is at a different location.
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