초록 ▼

The present invention relates to methods and compositions which employ low concentrations of combinations of zinc salts to prevent the irritation of skin or mucous membranes that may be caused by therapeutic agents, by personal hygiene products, by articles such as gloves or condoms, or by various p

The present invention relates to methods and compositions which employ low concentrations of combinations of zinc salts to prevent the irritation of skin or mucous membranes that may be caused by therapeutic agents, by personal hygiene products, by articles such as gloves or condoms, or by various physical, chemical, mechanical, or biological irritants.

대표청구항 ▼

We claim: 1. A coating for application to an article, comprising: two water soluble zinc salts, each at a concentration of between 0.1 and 1 weight percent; a first water insoluble zinc salt at a concentration of between about 0.1 and 1 weight percent; panthenol at a concentration of between about

We claim: 1. A coating for application to an article, comprising: two water soluble zinc salts, each at a concentration of between 0.1 and 1 weight percent; a first water insoluble zinc salt at a concentration of between about 0.1 and 1 weight percent; panthenol at a concentration of between about 0.05 and 5 weight percent; and glycerin, at a concentration between about 0 and 5 weight percent. 2. The coating according to claim 1, further comprising a third water soluble zinc salt at a concentration of between 0.1 and 1 weight percent. 3. The coating according to claim 1 or 2, wherein the combined amounts of all water soluble zinc salts is between about 0.1 and 0.5 weight percent. 4. The coating according to claim 1 or 2, where the water soluble zinc salts are selected from the group consisting of zinc acetate, zinc butyrate, zinc gluconate, zinc glycerate, zinc glycolate, zinc formate, zinc lactate, zinc picolinate, zinc priopionate, zinc salicylate, zinc tartrate, and zinc undecylenate. 5. The coating according to claim 3, where the water soluble zinc salts are selected from the group consisting of zinc acetate, zinc butyrate, zinc glycerate, zinc gluconate, zinc glycolate, zinc formate, zinc lactate, zinc picolinate, zinc priopionate, zinc salicylate, zinc tartrate and zinc undecylenate. 6. The coating according to claim 1, 2, 3 or 4, further comprising a second water insoluble zinc salt. 7. The coating according to claim 6, wherein the first or second water insoluble zinc salt is selected from the group consisting of zinc oxide, zinc stearate, zinc phosphate, zinc carbonate, zinc borate and zinc citrate. 8. A coating for application to an article, comprising: two water soluble zinc salts, each at a concentration of between 0.1 and 1 weight percent; panthenol at a concentration of between about 0.05 and 5 weight percent; and an effective amount of an antimicrobial agent. 9. The coating of claim 8, where the antimicrobial agent is selected from the group consisting of biguanides, iodophors, quaternary ammonium compounds, phenoxyethanol, phenylethyl alcohol, 2,4-dichlorobenzyl alcohol, thiomersal, clindamycin, erythromycin, benzoyl peroxide, mupirocin, bacitracin, polymyxin B, neomycin, triclosan, parachlorometaxylenol, foscarnet, miconazole, fluconzaole, itriconazole and ketoconazole. 10. The coating according to claim 8, further comprising a third water soluble zinc salt at a concentration of between 0.1 and 1 weight percent. 11. The coating according to claim 8, 9, or 10, wherein the combined amounts of all water soluble zinc salts is between about 0.1 and 0.5 weight percent. 12. The coating according to claim 8, 9 or 10 where the water soluble zinc salts are selected from the group consisting of zinc acetate, zinc butyrate, zinc glycerate, zinc gluconate, zinc glycolate, zinc formate, zinc lactate, zinc picolinate, zinc priopionate, zinc salicylate, zinc tartrate and zinc undecylenate. 13. The coating according to claim 11, where the water soluble zinc salts are selected from the group consisting of zinc acetate, zinc butyrate, zinc glycerate, zinc gluconate, zinc glycolate, zinc formate, zinc lactate, zinc picolinate, zinc priopionate, zinc salicylate, zinc tartrate and zinc undecylenate. 14. The coating according to claim 8, further comprising a water insoluble zinc salt. 15. The coating according to claim 14, wherein the water insoluble zinc salt is selected from the group consisting of zinc oxide, zinc citrate, zinc phosphate, zinc carbonate, zinc borate and zinc stearate. 16. The coating of claim 1 or 2, further comprising an emollient solvent at a concentration of less than 5 weight percent. 17. The coating of claim 6, further comprising an emollient solvent at a concentration of less than 5 weight percent. 18. The coating of claim 7, further comprising an emollient solvent at a concentration of less than 5 weight percent. 19. The coating of claim 8, further comprising an emollient solvent at a concentration of less than 5 weight percent. 20. The coating of claim 9, further comprising an emollient solvent at a concentration of less than 5 weight percent. 21. The coating of claim 10, further comprising an emollient solvent at a concentration of less than 5 weight percent. 22. The coating of claim 11, further comprising an emollient solvent at a concentration of less than 5 weight percent. 23. The coating of claim 12, further comprising an emollient solvent at a concentration of less than 5 weight percent. 24. The coating of claim 13, further comprising an emollient solvent at a concentration of less than 5 weight percent. 25. The coating of claim 14, further comprising an emollient solvent at a concentration of less than 5 weight percent. 26. The coating of claim 15, further comprising an emollient solvent at a concentration of less than 5 weight percent. 27. An article having a surface to which a coating according to claim 1 has been applied. 28. An article having a surface to which a coating according to claim 2 has been applied. 29. An article having a surface to which a coating according to claim 3 has been applied. 30. An article having a surface to which a coating according to claim 4 has been applied. 31. An article having a surface to which a coating according to claim 5 has been applied. 32. An article having a surface to which a coating according to claim 6 has been applied. 33. An article having a surface to which a coating according to claim 7 has been applied. 34. An article having a surface to which a coating according to claim 8 has been applied. 35. An article having a surface to which a coating according to claim 9 has been applied. 36. An article having a surface to which a coating according to claim 10 has been applied. 37. An article having a surface to which a coating according to claim 11 has been applied. 38. An article having a surface to which a coating according to claim 12 has been applied. 39. An article having a surface to which a coating according to claim 13 has been applied. 40. An article having a surface to which a coating according to claim 14 has been applied. 41. An article having a surface to which a coating according to claim 15 has been applied. 42. An article having a surface to which a coating according to claim 16 has been applied. 43. An article having a surface to which a coating according to claim 17 has been applied. 44. An article having a surface to which a coating according to claim 18 has been applied. 45. An article having a surface to which a coating according to claim 19 has been applied. 46. An article having a surface to which a coating according to claim 20 has been applied. 47. An article having a surface to which a coating according to claim 21 has been applied. 48. An article having a surface to which a coating according to claim 22 has been applied. 49. An article having a surface to which a coating according to claim 23 has been applied. 50. An article having a surface to which a coating according to claim 24 has been applied. 51. An article having a surface to which a coating according to claim 25 has been applied. 52. An article having a surface to which a coating according to claim 26 has been applied. 53. A surgical hand wash, comprising: (i) two or more water soluble zinc salts wherein said zinc salts in total are present at a combined concentration of between about 0.1 and 0.5 percent (weight/weight); (ii) farnesol at a concentration of between about 0.3 and 1.0 percent (weight/weight); (iii) panthenol at a concentration of between about 0.2 and 5 percent (weight/weight); and (iv) a quaternary ammonium compound and a biguanide, wherein the total concentration of quaternary ammonium compound and biguainde is between about 0.05 and 2.0 percent (weight/weight). 54. The surgical hand wash of claim 53, wherein the zinc salts are zinc gluconate, present at a concentration of between about 0.10-0.25 percent (weight/weight) and zinc lactate, present at a concentration of about between about 0.10-0.25 percent (weight/weight). 55. A disinfectant soap, comprising: (i) two or more water soluble zinc salts, wherein said zinc salts in total are present at a combined concentration of between about 0.1 and 0.5 percent (weight/weight); (ii) farnesol at a concentration of between about 0.3 and 1.0 percent (weight/weight); (iii) panthenol at a concentration of between about 0.2 and 5 percent (weight/weight); and (iv) a quaternary ammonium compound and a second antimicrobial agent selected from the group consisting of a biguanide and a chlorinated phenol, wherein the total concentration of quaternary ammonium compound and second antimicrobial agent is between about 0.05 and 2.0 percent (weight/weight). 56. The disinfectant soap of claim 55, wherein the zinc salts are zinc gluconate, present at a concentration of between about 0.10-0.25 percent (weight/weight) and zinc lactate, present at a concentration of about between about 0.10-0.25 percent (weight/weight). 57. The disinfectant soap of claim 55, further comprising phenoxyethanol at a concentration of between about 0.3 and 1 percent (weight/weight). 58. The disinfectant soap of claim 56, further comprising phenoxyethanol at a concentration of between about 0.3 and 1 percent (weight/weight). 59. A composition comprising: at least one water soluble zinc salt at a concentration of between about 0.05 and 2.0% w/w; D,L panthenol at a concentration between about 0.05 and 5.0% w/w; and a gelling agent at a concentration of between about 0.05 and 0.3% w/w; where the composition provides an anti-irritant effect. 60. The composition of claim 59, further comprising hydroxylalkyl cellulose at a concentration of less than about 0.3% w/w. 61. The composition of claim 59, further comprising polyethylene oxide at a concentration of less than about 0.3% w/w. 62. The composition of claim 60, further comprising polyethylene oxide at a concentration of less than about 0.3% w/w. 63. The composition of claim 59, further comprising a cellulose acetate polymer at a concentration of less than about 0.3% w/w. 64. The composition of claim 60, further comprising a cellulose acetate polymer at a concentration of less than about 0.3% w/w. 65. The composition of claim 61, further comprising a cellulose acetate polymer at a concentration of less than about 0.3% w/w. 66. The composition of claim 62, further comprising a cellulose acetate polymer at a concentration of less than about 0.3% w/w. 67. An article having a surface to which a coating according to claim 59 has been applied.