초록

The invention provides methods and compositions for treating and preventing a skin rash secondary to anti-epidermal growth factor receptor (EGFR) therapy, where the method comprises applying a vitamin K analog or a phosphatase inhibitor to the skin.

대표청구항 ▼

What is claimed is: 1. A method for treating a skin rash secondary to an anti-epidermal growth factor receptor (EGFR) therapy in a subject receiving said therapy, the method comprising applying vitamin K3 to the skin in an amount effective to treat the skin rash. 2. The method of claim 1, wherein

What is claimed is: 1. A method for treating a skin rash secondary to an anti-epidermal growth factor receptor (EGFR) therapy in a subject receiving said therapy, the method comprising applying vitamin K3 to the skin in an amount effective to treat the skin rash. 2. The method of claim 1, wherein the anti-EGFR therapy is treatment with an anti-EGFR antibody. 3. The method of claim 2, wherein the anti-EGFR antibody is cetuximab. 4. The method of claim 1, wherein the anti-EGFR therapy is treatment with an EGFR tyrosine kinase inhibitor. 5. The method of claim 4, wherein the EGFR tyrosine kinase inhibitor is gefitinib or erlotinib. 6. The method of claim 1, wherein the vitamin K3 activates EGFR. 7. The method of claim 1, wherein the vitamin K3 is formulated in a pharmaceutical formulation suitable for topical administration. 8. The method of claim 1, wherein the vitamin K3 is applied to the face. 9. The method of claim 1, wherein the vitamin K3 is applied to the trunk. 10. The method of claim 1, comprising exposing skin cells to 0.01 mM vitamin K3. 11. The method of claim 1, comprising exposing skin cells to 15 mM vitamin K3. 12. The method of claim 1, comprising exposing skin cells to 30 mM vitamin K3. 13. The method of claim 1, comprising exposing skin cells to 100 mM vitamin K3. 14. The method of claim 1, comprising applying the vitamin K3 twice daily. 15. The method of claim 1, comprising applying vitamin K3 daily. 16. The method of claim 1, comprising applying the vitamin K3 every other day.