Polymer compositions with bioactive agent, medical articles, and methods
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C08K-009/10
C08K-003/22
A61L-015/00
출원번호
UP-0728439
(2003-12-05)
등록번호
US-7745509
(2010-07-19)
발명자
/ 주소
Burton, Scott A.
Hyde, Patrick D.
Rao, Prabhakara S.
Ylitalo, Caroline M.
출원인 / 주소
3M Innovative Properties Company
대리인 / 주소
Adamson, Trisha D.
인용정보
피인용 횟수 :
15인용 특허 :
86
초록
A polymer composition that includes a hydrophilic polymer, an optional secondary organic polymer, and a bioactive agent distributed therein, wherein the bioactive agent is selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof.
대표청구항▼
What is claimed is: 1. A polymer composition comprising: a continuous hydrophobic phase comprising a mixture comprising: a hydrophobic liquid comprising mineral oil; and a hydrophobic thermoplastic elastomeric polymer; absorbent hydrophilic microparticles dispersed within the hydrophobic liquid, w
What is claimed is: 1. A polymer composition comprising: a continuous hydrophobic phase comprising a mixture comprising: a hydrophobic liquid comprising mineral oil; and a hydrophobic thermoplastic elastomeric polymer; absorbent hydrophilic microparticles dispersed within the hydrophobic liquid, wherein the hydrophilic microparticles comprise a crosslinked carboxylic acid-containing organic polymer; and a bioactive agent having a particle size less than one micron dispersed in the hydrophilic microparticles, wherein the bioactive agent is selected from the group consisting of a metal oxide of silver, a metal oxide of copper, a metal oxide of zinc, and combinations thereof; wherein the polymer composition is nonadherent and contains less than 1 wt % water based on the total weight of the composition. 2. The polymer composition of claim 1 wherein the absorbent hydrophilic microparticles have an average particle size of 10 microns or less, when in a nonhydrated form. 3. The polymer composition of claim 2 wherein the absorbent hydrophilic microparticles have an average particle size of 1 micron or less, when in a nonhydrated form. 4. The polymer composition of claim 3 wherein the absorbent hydrophilic microparticles have an average particle size of 0.5 micron to 1 micron when in a nonhydrated form. 5. The polymer composition of claim 2 further comprising secondary absorbent particles having an average particle size of greater than 10 microns when in a nonhydrated form. 6. The polymer composition of claim 5 wherein the secondary absorbent particles having an average particle size of greater than 10 microns are superabsorbent. 7. The polymer composition of claim 1 wherein the microparticles are superabsorbent. 8. The polymer composition of claim 1 wherein the carboxylic acid-containing organic polymer comprises a copolymer of sodium acrylate and acrylic acid. 9. The polymer composition of claim 1 wherein the thermoplastic elastomeric polymer is selected from the group consisting of a styrene-isoprene block copolymer, a styrene-(ethylene/butylene) block copolymer, a styrene-(ethylene/propylene) block copolymer, a styrene-isoprene-styrene block copolymer, a styrene-butadiene block copolymer, a polyetherester, a poly-alpha-olefin based thermoplastic elastomeric polymer, an ethylene-1-octene copolymer, and combinations thereof. 10. The polymer composition of claim 9 wherein the thermoplastic elastomeric polymer is selected from the group consisting of styrene-isoprene-styrene (SIS), styrene-butadiene-styrene (SBS), styrene-ethylene-propylene-styrene (SEPS), styrene-ethylene-butylene-styrene (SEBS), and combinations thereof. 11. The polymer composition of claim 1 further comprising an additive selected from the group consisting of a plasticizer, a crosslinking agent, a stabilizer, an extruding aid, a filler, a pigment, a dye, a swelling agent, a foaming agent, a chain transfer agent, and combinations thereof. 12. The polymer composition of claim 1 wherein the microparticles are present in an amount of 1 wt-% to 60 wt-%, based on the total weight of the polymer composition. 13. The polymer composition of claim 1 wherein the composition is stable. 14. The polymer composition of claim 1 wherein the composition is in the form of a hydrocolloid. 15. The polymer composition of claim 1 further comprising a swelling agent. 16. The polymer composition of claim 1 wherein the bioactive agent is silver oxide. 17. A medical article comprising the polymer composition of claim 1. 18. A polymer composition comprising: a continuous hydrophobic phase comprising a mixture comprising: mineral oil; and a hydrophobic thermoplastic elastomeric polymer selected from the group consisting of styrene-isoprene-styrene (SIS), styrene-butadiene-styrene (SBS), styrene-ethylene-propylene-styrene (SEPS), styrene-ethylene-butylene-styrene (SEBS), and combinations thereof; absorbent hydrophilic microparticles dispersed within the mineral oil, wherein the hydrophilic microparticles comprise a crosslinked carboxylic acid-containing organic polymer; and a bioactive agent having a particle size less than one micron dispersed in the hydrophilic microparticles, wherein the bioactive agent is selected from the group consisting of a metal oxide of silver, a metal oxide of copper, a metal oxide of zinc, and combinations thereof; wherein the polymer composition is nonadherent and contains less than 1 wt % water based on the total weight of the composition. 19. The polymer composition of claim 18 wherein the bioactive agent is silver oxide. 20. The polymer composition of claim 18 wherein the carboxylic acid-containing organic polymer comprises a copolymer of sodium acrylate and acrylic acid. 21. A medical article comprising the polymer composition of claim 18. 22. A polymer composition comprising: a continuous hydrophobic phase comprising a mixture comprising: mineral oil; and a hydrophobic thermoplastic elastomeric polymer selected from the group consisting of styrene-isoprene-styrene (SIS), styrene-butadiene-styrene (SBS), styrene-ethylene-propylene-styrene (SEPS), styrene-ethylene-butylene-styrene (SEBS), and combinations thereof; absorbent hydrophilic microparticles dispersed within the mineral oil, wherein the hydrophilic microparticles comprise a crosslinked a copolymer of sodium acrylate and acrylic acid; and silver oxide having a particle size less than one micron dispersed in the hydrophilic microparticles; wherein the polymer composition is nonadherent and contains less than 1 wt % water based on the total weight of the composition. 23. A medical article comprising the polymer composition of claim 22.
Young ; Sr. Richard H. (Federal Way WA) Neogi Amar N. (Seattle WA) Hansen Michael R. (Seattle WA) Hodgson Kevin T. (Seattle WA) Halabisky Donald D. (Tacoma WA) Marsh David G. (Federal Way WA) Brunnen, Binder coated discontinuous fibers with adhered particulate materials.
Leihr Charles M. (New Richmond WI) Tushaus Leonard A. (Hasting MN) Hoffman Jerome J. (White Bear MN) Wiederholt Gary (West St. Paul MN), Block copolymer, method of making the same, dimaine precursors of the same, method of making such diamines and end produ.
Jeffrey J. Cernohous ; Douglas A. Devens, Jr. ; Maria B. Urquiola ; Paul Hattam ; Patrick D. Hyde ; Richard A. Kollaja DE, Compatibilized pressure-sensitive adhesives.
Funk Rudiger,DEX ; Herfert Norbert,DEX ; Wanior Mariola,DEX ; Brown Patricia D. ; Engelhardt Fritz ; Woodrum Guy T., Crosslinked, hydrophilic, highly swellable hydrogels, production thereof and use thereof.
Hartman William G. (Seven Hills OH) Epple Thomas C. (Madison OH) Mann Roger H. (Corona del Mar CA) Sun Edward I. (Alhambra CA), Flexographic plate mounting tape.
Ali M. Zaki (Woodbury MN) Ali Mahfuza B. (Woodbury MN) Moren Dean M. (North St. Paul MN), High speed aqueous solvent developable photopolymer compositions.
Kenndoff Jochen,DEX ; Lenuck Vadim,DEX ; Sachau Gunther,DEX, Hydrophilic polyurethane gel foams, particularly for treating deep wounds, wound dressing based on hydrophilic polyuret.
Koto Noriaki (Ichihara JPX) Yukawa Joei (Ichihara JPX) Moro Takeo (Ichihara JPX), Process for the production of a silver coated copper powder and conductive coating composition.
Burrell Robert E. (Sherwood Park CAX) McIntosh Catherine L. (Sherwood Park CAX) Morris Larry R. (Yarker CAX), Process of activating anti-microbial materials.
Babu Gaddam N. (Woodbury MN) Christopher Susan S. (Spring City WI) Copley Bruce C. (Shoreview MN) Overstreet Thomas S. (Austin TX), Radiation curable polyolefin pressure sensitive adhesive.
Burton, Scott A.; Hyde, Patrick D.; Rao, Prabhakara S.; Ylitalo, Caroline M., Polymer compositions with bioactive agent, medical articles, and methods.
Vignaux, Jean-Jacques, Seismic streamer formed of sections comprising a main sheath covered with an external sheath formed using a thermoplastic material loaded with a biocide material.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.