IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0498782
(2002-12-16)
|
등록번호 |
US-7749442
(2010-07-26)
|
우선권정보 |
JP-2001-381606(2001-12-14); JP-2001-381607(2001-12-14) |
국제출원번호 |
PCT/JP2002/013137
(2002-12-16)
|
§371/§102 date |
20040610
(20040610)
|
국제공개번호 |
WO03/052427
(2003-06-26)
|
발명자
/ 주소 |
- Koike, Masufumi
- Mizutani, Satoru
|
출원인 / 주소 |
|
대리인 / 주소 |
Knobbe Martens Olson & Bear LLP
|
인용정보 |
피인용 횟수 :
3 인용 특허 :
8 |
초록
▼
The present invention provides a sample measuring device capable of allowing not only one but more than one kind of samples to react with a reagent, and enhancing a reliability in photometric analysis accuracy by reliably mixing and agitating the sample and the reagent prior to the photometric analy
The present invention provides a sample measuring device capable of allowing not only one but more than one kind of samples to react with a reagent, and enhancing a reliability in photometric analysis accuracy by reliably mixing and agitating the sample and the reagent prior to the photometric analysis. The device includes a reagent melting/mixing means, a sample supply chamber positioned on the upstream side of, and communicating with, the reagent melting/mixing means when the sample is allowed to flow into the reagent melting/mixing means, and at least one measuring chamber positioned on the downstream side of, and communicating with, the reagent melting/mixing means, wherein the sample supply chamber, the reagent melting/mixing means, and the measuring chamber are arranged sequentially from the upstream to the downstream directions of the flow passage, with the sample supply chamber positioned on the upstream side with respect to the sample flow by a sample moving means. When a centrifugal machine is used as a reagent moving means and the sample measuring device is installed and used with its imaginary axis kept along the radial direction of a rotor of the centrifugal machine, the sample supply chamber can be provided to be positioned on the radially inner side of the rotor in the centrifugal machine.
대표청구항
▼
The invention claimed is: 1. A sample measuring device comprising: at least one reagent melting/mixing means; a sample supply chamber communicating with the reagent melting/mixing means to cause a sample to flow into the reagent melting/mixing means; and at least one measuring chamber communicating
The invention claimed is: 1. A sample measuring device comprising: at least one reagent melting/mixing means; a sample supply chamber communicating with the reagent melting/mixing means to cause a sample to flow into the reagent melting/mixing means; and at least one measuring chamber communicating with the reagent melting/mixing means, wherein the sample supply chamber, the reagent melting/mixing means, and the measuring chamber are arranged from an upstream to a downstream side of a flow passage for a sample, which is moved by a sample moving means, and that the sample supply chamber is arranged on an upstream side of the reagent melting/mixing means, and the measuring chamber is arranged on a downstream side of the reagent melting/mixing means, and wherein the reagent melting/mixing means comprises a reagent melting chamber accommodating a reagent that is to react with the sample and a mixing chamber communicating with the reagent melting chamber through a siphon, a bypass passage, connecting the sample supply chamber and the measuring chamber, bypassing at least one of the following components provided between the sample supply chamber and the measuring chamber: the reagent melting chamber, the mixing chamber, and the reagent melting/mixing means including the reagent melting chamber and the mixing chamber, and wherein, when an action force causing the sample to flow from the sample supply chamber to the measuring chamber is imparted to the sample measuring device, there is generated a time lag in sample inflow into the measuring chamber such that, as compared with the flow passage which allows the sample from the sample supply chamber to reach the measuring chamber through the reagent melting/mixing means, the flow passage which allows the sample to reach the measuring chamber through the bypass passage causes the sample to flow into the measuring chamber through the bypass passage before the sample from the sample supply chamber reaches the measuring chamber through the reagent melting/mixing means, and wherein, at least a portion of the sample received from the bypass passage is positioned for measurement and, thereafter, at least a portion of the sample received from the reagent melting/mixing means is positioned for measurement. 2. A sample measuring device according to claim 1, wherein one measuring chamber is configured to measure at least a portion of the sample received from the bypass passage and, thereafter, measure at least a portion of the sample received from the reagent melting/mixing means. 3. A sample measuring device, comprising: at least one reagent melting/mixing section; a sample supply chamber communicating with said reagent melting/mixing section to cause a sample to flow into said reagent melting/mixing section; and at least one measuring chamber communicating with said reagent melting/mixing section, wherein the sample supply chamber, said reagent melting/mixing section, and the measuring chamber are arranged from an upstream to a downstream side of a flow passage for a sample, which is moved by a sample moving section, and that the sample supply chamber is arranged on an upstream side of said reagent melting/mixing section, and the measuring chamber is arranged on a downstream side of said reagent melting/mixing section, wherein the reagent melting/mixing section comprises a reagent melting chamber accommodating a reagent that is to react with the sample and a mixing chamber communicating with the reagent melting chamber through a siphon, a bypass passage, connecting the sample supply chamber and the measuring chamber, bypassing at least one of the following components provided between the sample supply chamber and the measuring chamber: the reagent melting chamber, the mixing chamber, and the reagent melting/mixing means including the reagent melting chamber and the mixing chamber, and wherein, when an action force causing the sample to flow from the sample supply chamber to the measuring chamber is imparted to the sample measuring device, there is generated a time lag in sample inflow into the measuring chamber such that, as compared with the flow passage which allows the sample from the sample supply chamber to reach the measuring chamber though the reagent melting/mixing means, the flow passage which allows the sample to reach the measuring chamber through the bypass passage causes the sample to flow into the measuring chamber through the bypass passage before the sample from the sample supply chamber reaches the measuring chamber trough the reagent melting/mixing means, and wherein at least a portion of the sample received from the bypass passage is positioned for measurement and, thereafter, at least a portion of the sample received from the reagent melting/mixing section is positioned for measurement. 4. A sample measuring device according to claim 3, wherein a plurality of reagent melting/mixing sections communicate with each other though siphons. 5. A sample measuring device according to claim 3, wherein one measuring chamber is configured to measure at least a portion of the sample received from the bypass passage and, thereafter, measure at least a portion of the sample received from the reagent melting/mixing section. 6. A sample measuring device comprising: at least one reagent melting/mixing means; a sample supply chamber communicating with the reagent melting/mixing means to cause a sample to flow into the reagent melting/mixing means; and at least one measuring chamber communicating with the reagent melting/mixing means, wherein the sample supply chamber, the reagent melting/mixing means, and the measuring chamber are arranged from an upstream to a downstream side of a flow passage for a sample, which is moved by a sample moving means, and that the sample supply chamber is arranged on an upstream side of the reagent melting/mixing means, and the measuring chamber is arranged on a downstream side of the reagent melting/mixing means, wherein the reagent melting/mixing means comprises a reagent melting chamber accommodating a reagent that is to react with the sample and a mixing chamber communicating with the reagent melting chamber through a siphon, and wherein the reagent is a dried reagent which is prepared by applying a reagent to a film and drying it, a bypass passage, connecting the sample supply chamber and the measuring chamber, bypassing at least one of the following components provided between the sample supply chamber and the measuring chamber: the reagent melting chamber, the mixing chamber, and the reagent melting/mixing means including the reagent melting chamber and the mixing chamber, and wherein, when an action force causing the sample to flow from the sample supply chamber to the measuring chamber is imparted to the sample measuring device, there is generated a time lag in sample inflow into the measuring chamber such that, as compared with the flow passage which allows the sample from the sample supply chamber to reach the measuring chamber through the reagent melting/mixing means, the flow passage which allows the sample to reach the measuring chamber through the bypass passage causes the sample to flow into the measuring chamber through the bypass passage before the sample from the sample supply chamber reaches the measuring chamber through the reagent melting/mixing means, and wherein, at least a portion of the sample received from the bypass passage is positioned for measurement and, thereafter, at least a portion of the sample received from the reagent melting/mixing means is positioned for measurement. 7. A sample measuring device according to claim 6, wherein one measuring chamber is configured to measure at least a portion of the sample received from the bypass passage and, thereafter, measure at least a portion of the sample received from the reagent melting/mixing means. 8. A sample measuring device comprising: at least one reagent melting/mixing means; a sample supply chamber communicating with the reagent melting/mixing means to cause a sample to flow into the reagent melting/mixing means; and at least one measuring chamber communicating with the reagent melting/mixing means, wherein the sample supply chamber, the reagent melting/mixing means, and the measuring chamber are arranged from an upstream to a downstream side of a flow passage for a sample, which is moved by a sample moving means, and that the sample supply chamber is arranged on an upstream side of the reagent melting/mixing means, and the measuring chamber is arranged on a downstream side of the reagent melting/mixing means, and wherein when an action force causing the sample to flow from the sample supply chamber to the measuring chamber is imparted to the sample measuring device, there is generated a time lag in sample inflow into the measuring chamber such that, as compared with the flow passage which allows the sample from the sample supply chamber to reach the measuring chamber through the reagent melting/mixing means, the flow passage which allows the sample to reach the measuring chamber through a bypass passage, connecting the sample supply chamber and the measuring chamber causes the sample to flow into the measuring chamber through the bypass passage before the sample from the sample supply chamber reaches the measuring chamber through the reagent melting/mixing means, and wherein, at least a portion of the sample received from the bypass passage is positioned for measurement and, thereafter, at least a portion of the sample received from the reagent melting/mixing means is positioned for measurement. 9. A sample measuring device according to claim 8, wherein one measuring chamber is configured to measure at least a portion of the sample received from the bypass passage and, thereafter, measure at least a portion of the sample received from the reagent melting/mixing means. 10. A sample measuring device according to claim 8, further comprising a disposal chamber, and wherein liquid, which has passed through the bypass communication passage, enters the measuring chamber and the blank measurement is performed, and the liquid in the measuring chamber enters the disposal chamber, and then reagent melting liquid, which has passed through the melting/mixing means, enters the measuring chamber. 11. A sample measuring device according to claim 8, further comprising a siphon tubule, which extends along a reagent melting chamber of one of the at least one reagent melting/mixing means in the direction opposite to a centrifugal direction, turns back, at a position beyond the reagent melting chamber, to extend in the centrifugal direction. 12. A sample measuring device according to claim 8, further comprising at least one rib formed on a surface of the sample measuring device so that an inner side of a cover plate can be brought into press contact with an upper edge of the ribs. 13. A sample measuring device according to claim 8, wherein the at least one reagent melting/mixing means comprises a first reagent melting/mixing means and a second reagent melting/mixing means. 14. A sample measuring device according to claim 13, further comprising a first back-flow preventing chamber, a siphon tubule and a first passage, wherein the first back-flow preventing chamber communicates, through the siphon tubule, with the first reagent melting/mixing means and communicates, through the first passage, with an end, in a centrifugal direction, of a reagent melting chamber of the second reagent melting/mixing means. 15. A sample measuring device according to claim 13, further comprising a second back-flow preventing chamber and a third back-flow preventing chamber, wherein the at least one measuring chamber comprises a first measuring chamber and a second measuring chamber, and wherein a mixing chamber of the second reagent melting/mixing means communicates with the first measuring chamber and the second measuring chamber successively through a reverse-U-shaped tubule, the second back-flow preventing chamber, a second passage, and the third back-flow preventing chamber. 16. A sample measuring device comprising: at least one reagent melting/mixing means; a sample supply chamber communicating with the reagent melting/mixing means, wherein the sample supply chamber, the reagent melting/mixing means, and the passage for a sample, which is moved by a sample moving means, and that the sample supply chamber is arranged on an upstream side of the reagent melting/mixing means, and the measuring chamber is arranged on a downstream side of the reagent melting/mixing means; and wherein the at least one measuring chamber comprises at least two measuring chambers, one of the measuring chambers having a large cell length, and the other of the measuring chambers having a small cell length. 17. A sample measuring device according to claim 16, wherein one of the measuring chambers has a large depth, and the other of the measuring chambers has a small depth. 18. A sample measuring device according to claim 8, characterized in that the sample moving means is a centrifugal machine, and that, in use, the sample measuring device is installed in the centrifugal machine such that the sample supply chamber, the reagent melting/mixing means, and the measuring chamber are successively arranged along a radial direction of a rotor of the centrifugal direction and such that the sample supply chamber is situated on an inner side with respect to the radial direction of the rotor of the centrifugal machine. 19. A sample measuring device according to claim 8, characterized in that a plurality of reagent melting/mixing means communicate with each other through siphons. 20. A sample measuring device according to claim 8, characterized in that the sample moving means is a pressure generating means. 21. A sample measuring device according to claim 8, characterized in that there is provided a liquid flow control means equipped with a valve body and a means for detecting the sample. 22. A sample measuring device according to claim 8, characterized in that the flow passage is equipped with at least one back-flow preventing means. 23. A sample measuring device according to claim 8, characterized in that there are provided at least two of the measuring chambers, one of the measuring chambers is a measuring chamber communicating with the bypass passage and dedicated to sample blank measurement, and the other of the measuring chambers is a measuring chamber communicating with the sample supply chamber through the at least one reagent melting/mixing means. 24. A sample measuring device according to claim 8, characterized in that there are provided at least two of the measuring chambers, one of the measuring chambers is a measuring chamber with a large cell length, and the other of the measuring chambers is a measuring chamber with a small cell length. 25. A sample measuring device according to claim 8, characterized in that properties of a reaction sample flowing into the measuring chamber are measured by an optical measuring means or an electro-chemical measuring means. 26. A sample measuring device according to claim 8, characterized in that an air vent hole is provided at least in the reagent melting/mixing means. 27. A sample measuring device according to claim 8, further comprising an overflow chamber communicating with the measuring chamber, with the overflow chamber being situated on a downstream side of the chamber adjacent to and on an upstream side of the measuring chamber. 28. A sample measuring device according to claim 8, further comprising a disposal chamber communicating with the measuring chamber, with the disposal chamber being situated on a downstream side of the measuring chamber. 29. A sample measuring device according to claim 8, wherein a plurality of reagent melting/mixing means communicate with each other through siphons. 30. A sample measuring device according to claim 8, wherein the at least one reagent melting/mixing means comprises a first reagent melting/mixing means and a second reagent melting/mixing means. 31. A sample measuring device according to claim 30, further comprising a first back-flow preventing chamber, a siphon tubule and a first passage, wherein the first back-flow preventing chamber communicates, through the siphon tubule, with the first reagent melting/mixing means and communicates, through the first passage, with an end, in a centrifugal direction, of a reagent melting chamber of the second reagent melting/mixing means. 32. A sample measuring device according to claim 30, further comprising a second back-flow preventing chamber and a third back-flow preventing chamber, wherein the at least one measuring chamber comprises a first measuring chamber and a second measuring chamber, and wherein a mixing chamber of the second reagent melting/mixing means communicates with the first measuring chamber and the second measuring chamber successively through a reverse-U-shaped tubule, the second back-flow preventing chamber, a second passage, and the third back-flow preventing chamber. 33. A sample measuring device according to claim 8, further comprising a siphon tubule, which extends along a reagent melting chamber of one of the at least one reagent melting/mixing means in the direction opposite to a centrifugal direction, turns back, at a position beyond the reagent melting chamber, to extend in the centrifugal direction. 34. A sample measuring device according to claim 8, further comprising at least one rib formed on a surface of the sample measuring device so that an inner side of a cover plate can be brought into press contact with an upper edge of the ribs. 35. A sample measuring device according to claim 8, wherein the sample moving means is a pressure generating means, and wherein the sample measuring device is provided with a liquid flow control means equipped with a valve body and a means for detecting the sample.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.