IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0839037
(2007-08-15)
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등록번호 |
US-7754059
(2010-08-02)
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발명자
/ 주소 |
- Forrow, Nigel John
- Zhang, Xiang Cheng
- McTigue, Catherine Ann
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
1 인용 특허 :
9 |
초록
▼
A biosensor for determining the concentration of an analyte in a biological sample. The biosensor comprises a support, a reference electrode or a counter electrode or both disposed on the support, a working electrode disposed on the support, the working electrode spaced apart from the other electrod
A biosensor for determining the concentration of an analyte in a biological sample. The biosensor comprises a support, a reference electrode or a counter electrode or both disposed on the support, a working electrode disposed on the support, the working electrode spaced apart from the other electrode or electrodes on the support, a covering layer defining a sample chamber over the electrodes, an aperture in the covering layer for receiving a sample, and at least one layer of mesh in the sample chamber between the covering layer and the electrodes. The at least one layer of mesh has coated thereon a silicone surfactant. Certain silicone surfactants are as effective as fluorinated surfactants with respect to performance of biosensors. These surfactants, when coated onto the mesh layer of the biosensor, are effective in facilitating the transport of aqueous test samples, such as blood, in the sample chamber.
대표청구항
▼
What is claimed is: 1. A biosensor comprising a support, an arrangement of electrodes comprising a working electrode and a counter electrode disposed on the support, a covering layer defining an enclosed space over the electrodes, and at least one mesh layer in the enclosed space between the coveri
What is claimed is: 1. A biosensor comprising a support, an arrangement of electrodes comprising a working electrode and a counter electrode disposed on the support, a covering layer defining an enclosed space over the electrodes, and at least one mesh layer in the enclosed space between the covering layer and the electrodes, the at least one mesh layer coated with at least one silicone surfactant, wherein the at least one silicone surfactant comprises a mixture of silicone surfactants and wherein the at least one mesh layer is less than 150 microns in thickness. 2. The biosensor of claim 1, wherein the mixture comprises a surfactant having high molecular weight having satisfactory properties with respect to stability of the biosensor and a surfactant having low molecular weight having satisfactory properties for rapid filling of the enclosed space over the electrodes. 3. The biosensor of claim 2, wherein the silicone surfactant of high molecular weight and the silicone surfactant of low molecular weight have the formula: wherein x ranges from 8 to 9, inclusive, y ranges from 3 to 4, inclusive, z ranges from 11 to 13, inclusive, and R being hydrogen for the silicone surfactant of high molecular weight; and x is 0, y is 1, z ranges from 3 to 15, inclusive, and R is hydrogen, methyl, or acetate for the surfactant of low molecular weight. 4. The biosensor of claim 2, wherein the weight fraction of the silicone surfactant of high molecular weight in the mixture ranges from 1% to 99%, inclusive. 5. The biosensor of claim 2, wherein the weight fraction of the silicone surfactant of low molecular weight in the mixture ranges from 1% to 99% inclusive. 6. The biosensor of claim 1, comprising a single layer of mesh. 7. The biosensor of claim 1, comprising two layers of mesh. 8. The biosensor of claim 1, wherein the at least one mesh layer comprises a woven or a non-woven material. 9. The biosensor of claim 1, wherein the at least one mesh layer comprises fibers, the fibers comprising a polyamide or a polyester. 10. The biosensor of claim 1, wherein the at least one mesh layer comprises fibers, the fibers having a diameter from about 70 to about 100 microns. 11. The biosensor of claim 1, wherein the at least one mesh layer comprises fibers, the at least one mesh layer having a fiber count of about 40 to about 60 per cm. 12. The biosensor of claim 1, further comprising an aperture in the covering layer for receiving a biological sample, wherein the electrode arrangement comprises a working electrode that includes an enzyme capable of catalyzing a reaction involving a substrate for the enzyme and a mediator capable of transferring electrons between the enzyme-catalyzed reaction and the working electrode to create a current related to the activity of the enzyme and related to a concentration of an analyte in the biological sample. 13. The biosensor of claim 12, wherein the analyte is glucose or a ketone body. 14. The biosensor of claim 1, wherein the biosensor further comprises a reference electrode. 15. The biosensor of claim 14, wherein the working electrode comprises a working ink deposited on an electrically conductive material, wherein said working ink comprises an enzyme and a redox mediator. 16. The biosensor of claim 15, wherein the enzyme is glucose oxidase or glucose dehydrogenase. 17. The biosensor of claim 15, wherein the enzyme is 3-hydroxybutyrate dehydrogenase. 18. The biosensor of claim 1, wherein the biosensor further comprises an aperture in the covering layer for receiving a biological sample. 19. A biosensor comprising a support, an arrangement of electrodes comprising a working electrode and a counter electrode disposed on the support, a covering layer defining an enclosed space over the electrodes, and at least one mesh layer in the enclosed space between the covering layer and the electrodes, the at least one mesh layer coated with at least one silicone surfactant, wherein the at least one silicone surfactant comprises a mixture of silicone surfactants and wherein the at least one mesh layer has an average mesh opening from about 67 to about 180 microns. 20. The biosensor of claim 19, wherein the mixture of silicone surfactants comprises a rake-type surfactant. 21. The biosensor of claim 19, comprising a single layer of mesh. 22. The biosensor of claim 19, comprising two layers of mesh. 23. The biosensor of claim 19, wherein the at least one mesh layer has a thickness from about 100 to about 160 microns. 24. The biosensor of claim 19, wherein the at least one mesh layer comprises a woven or a non-woven material. 25. The biosensor of claim 19, wherein the at least one mesh layer comprises fibers, the fibers comprising a polyamide or a polyester. 26. The biosensor of claim 19, wherein the at least one mesh layer comprises fibers, the fibers having a diameter from about 70 to about 100 microns. 27. The biosensor of claim 19, wherein the at least one mesh layer comprises fibers, the at least one mesh layer having a fiber count of about 40 to about 60 per cm. 28. A biosensor comprising a support, an arrangement of electrodes comprising a working electrode and a counter electrode disposed on the support, a covering layer defining an enclosed space over the electrodes, and at least one mesh layer in the enclosed space between the covering layer and the electrodes, the at least one mesh layer coated with at least one silicone surfactant, wherein the at least one silicone surfactant comprises a trisiloxane surfactant and wherein the at least one mesh layer is less than 150 microns in thickness. 29. The biosensor of claim 28, wherein the biosensor further comprises a reference electrode. 30. The biosensor of claim 28, wherein the working electrode comprises a working ink deposited on an electrically conductive material, wherein said working ink comprises an enzyme and a redox mediator. 31. The biosensor of claim 30, wherein the enzyme is glucose oxidase or glucose dehydrogenase. 32. The biosensor of claim 30, wherein the enzyme is 3-hydroxybutyrate dehydrogenase. 33. The biosensor of claim 28, wherein the biosensor further comprises an aperture in the covering layer for receiving a biological sample. 34. The biosensor of claim 33, wherein the biosensor further comprises a reference electrode. 35. The biosensor of claim 34, wherein the enzyme is glucose oxidase or glucose dehydrogenase. 36. The biosensor of claim 34, wherein the enzyme is 3 hydroxybutyrate dehydrogenase. 37. The biosensor of claim 33, wherein the working electrode comprises a working ink deposited on an electrically conductive material, wherein said working ink comprises an enzyme and a redox mediator. 38. A biosensor comprising a support, an arrangement of electrodes comprising a working electrode and a counter electrode disposed on the support, a covering layer defining an enclosed space over the electrodes, and at least one mesh layer in the enclosed space between the covering layer and the electrodes, the at least one mesh layer coated with at least one silicone surfactant, wherein the at least one silicone surfactant comprises a cyclosiloxane surfactant and wherein the at least one mesh layer is less than 150 microns in thickness. 39. The biosensor of claim 38, wherein the biosensor further comprises an aperture in the covering layer for receiving a biological sample.
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