A medical device known as an implantable therapeutic substance delivery device is configured for implanting in humans to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spastisity, cancer, an
A medical device known as an implantable therapeutic substance delivery device is configured for implanting in humans to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spastisity, cancer, and many other conditions. The therapeutic substance delivery device has a permanent magnet solenoid pump that is energy efficient, accurate, small, compatible with therapeutic substances, and has many other improvements. The implantable therapeutic substance delivery device has a housing, a therapeutic substance reservoir, a power source, electronics, and a permanent magnet solenoid pump. The therapeutic substance reservoir is configured to contain a therapeutic substance and is coupled to the housing. The power source is carried in the housing to power the electronics and solenoid pump. The electronics are coupled to the solenoid pump and the solenoid pump is coupled to the therapeutic substance reservoir. The permanent magnet solenoid pump is configured for pumping therapeutic substance from the therapeutic substance reservoir through an infusion outlet at a programmed infusion rate. Many embodiments of the permanent magnet solenoid pump and its methods of operation are possible.
대표청구항▼
The invention claimed is: 1. An implantable therapeutic substance delivery device comprising: a first housing adapted for subcutaneous implantation, the first housing comprising an implantable, hermetically sealed unit; a second housing adapted for subcutaneous implantation, the second housing comp
The invention claimed is: 1. An implantable therapeutic substance delivery device comprising: a first housing adapted for subcutaneous implantation, the first housing comprising an implantable, hermetically sealed unit; a second housing adapted for subcutaneous implantation, the second housing comprising an implantable, hermetically sealed unit; a coupling connecting the first housing to the second housing; a fluid reservoir located within one of the first housing and the second housing; control electronics located within one of the first housing and the second housing; a power source located within one of the first housing and the second housing, the power source operably connected to the control electronics; an infusion outlet located on one of the first housing and the second housing; and a solenoid pump mechanism located within one of the first housing and the second housing, wherein the pump mechanism comprises a piston and is operably connected to the fluid reservoir and the infusion outlet such that the pump mechanism is capable of delivering a therapeutic substance in the fluid reservoir to the infusion outlet; wherein the pump mechanism and the fluid reservoir are not in the same housing. 2. A device according to claim 1, wherein the fluid reservoir is located within the first housing, and wherein the control electronics, the power source, and the pump mechanism are all located within the second housing. 3. A device according to claim 2, wherein the coupling comprises a fluid coupling operably connecting the fluid reservoir and the pump mechanism. 4. A device according to claim 2, further comprising a refill port located in the first housing, wherein the refill port is operably coupled to the fluid reservoir. 5. A device according to claim 1, wherein the coupling comprises a fluid coupling. 6. A device according to claim 1, further comprising a refill port located in one of the first housing or the second housing, wherein the refill port is operably coupled to the fluid reservoir. 7. A device according to claim 1, wherein the control electronics, the power source, and the pump mechanism are all located within one of the first housing or the second housing. 8. A device according to claim 1, wherein the pump mechanism is located in the first housing and the fluid reservoir is located in the second housing. 9. A device according to claim 1, wherein the first housing and the second housing are adapted for subcutaneous implantation on the head of a subject. 10. An implantable therapeutic substance delivery device comprising: a first housing, the first housing comprising an implantable, hermetically sealed unit; a second housing, the second housing comprising an implantable, hermetically sealed unit; a fluid reservoir located within one of the first housing and the second housing; control electronics located within one of the first housing and the second housing; a power source located within one of the first housing and the second housing, the power source operably connected to the control electronics; a pump mechanism located within one of the first housing and the second housing, wherein the pump mechanism comprises a solenoid pump comprising a piston; a fluid coupling extending between the first housing to the second housing, wherein the fluid coupling operably connects the fluid reservoir and the pump mechanism; and an infusion outlet located on one of the first housing and the second housing, wherein the pump mechanism is operably connected to the fluid reservoir and the infusion outlet such that the pump mechanism is capable of delivering a therapeutic substance in the fluid reservoir to the infusion outlet. 11. A device according to claim 10, further comprising a refill port located in one of the first housing or the second housing, wherein the refill port is operably coupled to the fluid reservoir. 12. A device according to claim 10, wherein the first housing and the second housing are each adapted for subcutaneous implantation in the head. 13. A device according to claim 10, wherein the control electronics, the power source, and the pump mechanism are all located within one of the first housing or the second housing. 14. A device according to claim 10, wherein the fluid reservoir is located within the first housing, and wherein the control electronics, the power source, and the pump mechanism are all located within the second housing. 15. An implantable therapeutic substance delivery device comprising: a first housing adapted for subcutaneous implantation, the first housing comprising an implantable, hermetically sealed unit; a second housing adapted for subcutaneous implantation, the second housing comprising an implantable, hermetically sealed unit; a fluid reservoir located within the first housing; control electronics located within the second housing; a power source located within the second housing, the power source operably connected to the control electronics; a pump mechanism located within the second housing, wherein the pump mechanism comprises a solenoid pump comprising a piston; an infusion outlet located on the second housing, wherein the pump mechanism is operably connected to the fluid reservoir and the infusion outlet such that the pump mechanism is capable of delivering a therapeutic substance in the fluid reservoir to the infusion outlet; and a fluid coupling extending between the first housing to the second housing, wherein the fluid coupling operably connects the fluid reservoir and the pump mechanism. 16. A device according to claim 15, wherein the first housing and the second housing are adapted for subcutaneous implantation on the head of a subject. 17. A method for infusing a therapeutic substance to an internal infusion site, the method comprising: subcutaneously implanting a therapeutic substance delivery device, wherein the device comprises: a first housing comprising an implantable, hermetically sealed unit subcutaneously implanted in a subject; a second housing comprising an implantable, hermetically sealed unit subcutaneously implanted in the subject; a fluid reservoir located within the first housing, the fluid reservoir comprising a therapeutic substance located therein; control electronics located within the second housing; a power source located within the second housing, the power source operably connected to the control electronics; a solenoid pump mechanism comprising a piston, the solenoid pump mechanism located within the second housing; and subcutaneously implanting a coupling extending between the first housing and the second housing; operating the pump mechanism to deliver the therapeutic substance in the fluid reservoir to an infusion site located outside of the first housing and the second housing, wherein the therapeutic substance passes from the fluid reservoir to the pump mechanism through the coupling; and controlling the pump mechanism using the control electronics. 18. A method according to claim 17, further comprising delivering the therapeutic substance to the fluid reservoir through a refill port located in one of the first housing or the second housing, wherein the refill port is operably coupled to the fluid reservoir. 19. A method according to claim 17, wherein the control electronics, the power source, and the pump mechanism are all located within the second housing. 20. A method according to claim 17, wherein the first housing and the second housing are subcutaneously implanted on the head of the subject.
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