Strontium-apatite cement preparations, cements formed therefrom, and uses thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-027/44
A61K-031/75
A61K-033/06
A61K-033/08
출원번호
UP-0359907
(2009-01-26)
등록번호
US-7758693
(2010-08-09)
우선권정보
DE-102 25 420(2002-06-07)
발명자
/ 주소
Wenz, Robert
출원인 / 주소
Kyphon Sarl
인용정보
피인용 횟수 :
3인용 특허 :
77
초록▼
Calcium-strontium-hydroxyphosphate (strontium-apatite-) cement preparations are described, comprising a powder mixture, which contains molar quantities of the components calcium (Ca), strontium (Sr) and phosphate (P) in the mixture in the ranges 1.00<Ca/P≦1.50 and 0<Sr/P<1.5, t
Calcium-strontium-hydroxyphosphate (strontium-apatite-) cement preparations are described, comprising a powder mixture, which contains molar quantities of the components calcium (Ca), strontium (Sr) and phosphate (P) in the mixture in the ranges 1.00<Ca/P≦1.50 and 0<Sr/P<1.5, together with an alkali salt or an ammonium salt of phosphoric acid, and with water and/or an aqueous solution. The powder mixture particularly contains, as the Ca-component, Ca3(PO4)2 (TCP), and as the Sr-component SrHPO4 and/or Sr3(PO4)2 and optionally additional SrCO3. As the aqueous mixing solution for the formation of the strontium-apatite cement, an aqueous solution of an alkali salt or an ammonium salt of the phosphoric acid is suitable.
대표청구항▼
What is claimed is: 1. A method for augmenting bone, the method comprising: providing a powder mixture component comprising a tricalcium orthophosphate and a strontium orthophosphate, wherein the molar ratio of calcium phosphate is 1 to about 1.5, and a molar ratio of strontium to phosphate is not
What is claimed is: 1. A method for augmenting bone, the method comprising: providing a powder mixture component comprising a tricalcium orthophosphate and a strontium orthophosphate, wherein the molar ratio of calcium phosphate is 1 to about 1.5, and a molar ratio of strontium to phosphate is not greater than about 1.5 and an aqueous component comprising a solution of a salt of an orthophosphoric acid selected from the group consisting of an alkali salt, an ammonium salt and a combination thereof; combining the powder mixture and the aqueous component to form a bone substitute, wherein the bone substitute contains no more than trace amounts of magnesium ions; and delivering the bone substitute to a site in contact with a bone. 2. The method for augmenting bone according to claim 1, further comprising forming the bone substitute into a predetermined shape. 3. The method for augmenting bone according to claim 1, further comprising closing a bone defect in a patient. 4. The method for augmenting bone according to claim 1, further comprising promoting anabolic activity in the bone of a patient. 5. The method for augmenting bone according to claim 1, wherein combining the powder mixture component and the aqueous component comprises forming a paste. 6. The method for augmenting bone according to claim 5, further comprising placing the paste into a mold and allowing the paste to harden into a molded shape. 7. The method for augmenting bone according to claim 6, further comprising inserting molded shape of bone substitute into a patient to augment a bone. 8. The method for augmenting bone according to claim 1, further comprising injecting the bone substitute into a site in a bone. 9. The method for augmenting bone according to claim 1, comprising filling a gap or defect in a bone. 10. The method for augmenting bone according to claim 1, further comprising adding a biological or pharmaceutical compound. 11. The method for augmenting bone according to claim 10, wherein adding a biological or pharmaceutical compound comprises adding a drug from the series of bone morphogenic proteins. 12. The method for augmenting bone according to claim 1, further comprising adding granular particles to the powder component and dissolving the granular particles in the aqueous component. 13. The method for augmenting bone according to claim 12, wherein the granular particles are about 10 μm to about 300 μm. 14. The method for augmenting bone according to claim 1, wherein the salt of an orthophosphoric acid is a primary or secondary sodium or potassium salt. 15. The method for augmenting bone according to claim 1, comprising delivering the bone substitute as a bone adhesive to a site in contact with a bone. 16. The method for augmenting bone according to claim 1, comprising delivering the bone substitute as a bone cement to a site in contact with a bone. 17. The method for augmenting bone according to claim 1, comprising delivering the bone substitute as a bone filler to a site in a bone. 18. The method for augmenting bone according to claim 11, further comprising promoting anabolic activity in the bone.
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이 특허에 인용된 특허 (77)
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Liu Sung-Tsuen (29 Landing Laguna Niguel CA 92677) Chung Harvey H. (43 Via Costa Verde Rancho Palos Verdes CA 90274), Calcium phosphate calcium sulfate composite implant material.
Brown Walter E. (Rockville MD) Chow Laurence C. (Germantown MD), Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements.
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Wallace Donald G. (Menlo Park CA) McMullin Hugh (Pacifica CA) Chu George (Cupertino CA), Injectable ceramic compositions and methods for their preparation and use.
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Lacout, Jean-Louis; Hatim, Zineb; Frache-Botton, Michele, Method for preparing a biomaterial based on hydroxyapatite, resulting biomaterial and surgical or dental use.
Crugnola Aldo M. (51 Frederick St. ; Unit 85 Dracut MA 01826) Ellis Edward J. (109 Jackman St. Georgetown MA 01969), Orthopaedic cement from acrylate polymers.
Inoue Senya (Soka JPX) Ono Akira (Soka JPX) Otaki Nobuyuki (Soka JPX), Process for the preparation of microspherical sintered bodies of hydroxyapatite and a chromatographic packing material c.
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Liu Sung-Tsuen (29 Landing Laguna Niguel CA 92677) Chung Harvey H. (43 Via Costa Verde Rancho Palos Verdes CA 90274), Resorbable bioactive calcium phosphate cement.
Liu Sung-Tsuen (29 Landing Laguna Niguel CA 92677) Chung Harvey H. (43 Via Costa Verde Rancho Palos Verdes CA 90274), Resorbable bioactive phosphate containing cements.
Reiley Mark A ; Scholten Arie ; Talmadge Karen D ; Scribner Robert M, Systems and methods for treating fractured or diseased bone using expandable bodies.
Faccioli Giovanni (Monzambano ITX) De Bastiani Basilio M. (Montegrotto ITX) Magnan Bruno (Verona ITX) Soffiatti Renzo (Nogara ITX), Two phase cement mixture, particularly suitable for othopaedics.
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