최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | UP-0812351 (2004-03-29) |
등록번호 | US-7758811 (2010-08-09) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 88 인용 특허 : 465 |
A multichannel system for classifying particles according to one or more characteristics of the particles includes a plurality of flow cytometry units. Each flow cytometry unit is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing particles using a
A multichannel system for classifying particles according to one or more characteristics of the particles includes a plurality of flow cytometry units. Each flow cytometry unit is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing particles using a beam of electromagnetic radiation. Each flow cytometry unit has a sensor operable to generate a time-varying output signal indicative of at least one characteristic of the particles in the stream of fluid as the stream of fluid is interrogated by the beam of electromagnetic radiation. The flow cytometry units share an integrated platform and perhaps even a common processor for receiving and processing information from the units. The common processor is programmed to receive the time-varying output signals from the flow cytometry units substantially continuously and to process the output signals.
What is claimed is: 1. A multi-channel system for classifying sperm cells according to one or more characteristics of the sperm cells, said system comprising: a plurality of flow cytometry units each of which is operable to provide sex sorted sperm from a mixture of sperm cells by interrogating a s
What is claimed is: 1. A multi-channel system for classifying sperm cells according to one or more characteristics of the sperm cells, said system comprising: a plurality of flow cytometry units each of which is operable to provide sex sorted sperm from a mixture of sperm cells by interrogating a stream of fluid containing said sperm cells using a beam of pulsed electromagnetic radiation, at least one sensor operable to generate a time-varying output signal indicative of at least one characteristic of the sperm cells; said units sharing an integrated platform comprising a common source of said pulsed electromagnetic radiation and a common processor for receiving and processing at least one output signal from the at least one sensor as a substantially continuous stream and to process the output signals in real time to send control signals to the flow cytometry units during a sorting process to adjust a sort operation as a function of said output signals received by the common processor. 2. The system of claim 1 wherein said common source of said pulsed electromagnetic radiation comprises a plurality of laser pulses, each pulse having a peak power that is greater than the average power output of a laser and a wavelength in a range of about 350-370 nm. 3. The system of claim 2 wherein said laser emits pulses having a width of about 1-100 picoseconds at a pulse frequency of about 50-150 MHz at a power of about 50-500 milliwatts. 4. The system of claim 3 wherein said sex sorted sperm has an enriched subpopulation having a coefficient of variation selected from a group consisting of: between about 2.0% and about 1.0%, between about 1.5% and about 1.0%, about 1.4%, and about 1.3%. 5. The system of claim 1 wherein said common source of said pulsed electromagnetic radiation comprises a single pulsed laser beam. 6. The system of claim 5 further comprising a beam splitting system for splitting the single pulsed laser beam into multiple beams and directing the multiple beams into optics systems of respective flow cytometry units. 7. The system of claim 1 wherein said integrated platform further comprises a common housing, said flow cytometry units comprising interchangeable modules removably mounted in the housing. 8. The system of claim 1 wherein each flow cytometry unit comprises an epi-illumination optics system for interrogating a respective fluid stream. 9. The system of claim 1 wherein said processor is operable to output an indication of the fluorescence intensity measured by each unit. 10. The system of claim 1 wherein said processor is operable to output an indication of the rate at which each unit is separating sperm cells. 11. The system of claim 1 wherein said processor is operable to output an indication of sperm cell staining variations. 12. The system of claim 1 wherein said processor is operable to output an indication of a decision boundary used by each unit for discriminating between sperm cells. 13. The system of claim 1 wherein said flow cytometry units are adapted to operate in parallel. 14. The system of claim 1 wherein said integrated platform further comprises a common input for controlling operation of the units. 15. The system of claim 14 wherein said plurality of flow cytometry units comprises a jet-in-air droplet sorting flow cytometry unit. 16. The system of claim 1 wherein the common processor receives and processes said information to permit evaluation of the operation of one unit relative to another unit. 17. The system of claim 1 wherein the processor is operable to process the information in real time. 18. The system of claim 1 wherein said integrated platform further comprises at least one of: (1) a common supply of sperm cells; (2) a common housing; (3) a common input for controlling operation of the units; and (4) a common fluid delivery system for delivering fluid containing said sperm cells to said flow cytometry units.
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