Medical electrode containing a hydrophilic polymer
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/04
H01B-001/12
출원번호
UP-0442797
(2006-05-30)
등록번호
US-7761131
(2010-08-09)
발명자
/ 주소
Copp-Howland, Warren W.
출원인 / 주소
Tyco Healthcare Group LP
대리인 / 주소
Winsor, Esq., Lisa E.
인용정보
피인용 횟수 :
1인용 특허 :
20
초록▼
Conductive compositions whose electrical properties do not change significantly due when stored open to the atmosphere, methods for preparing the compositions, and medical electrodes that comprise the compositions are disclosed. The compositions are hydrogels that comprise about 33 wt % to about 68
Conductive compositions whose electrical properties do not change significantly due when stored open to the atmosphere, methods for preparing the compositions, and medical electrodes that comprise the compositions are disclosed. The compositions are hydrogels that comprise about 33 wt % to about 68 wt % of a humectant or a mixture of humectants; about 1 wt % to about 8 wt % of an electrolyte or mixture of electrolytes; about 6 wt % to about 20 wt % of water; about 18 wt % to about 45 Wt % of a copolymer. The copolymer comprises, in polymerized form, about 80 mol % to about 95 mol % of a first monomer, which is a mixture of acrylic acid and a salt thereof, about 5 mol % to 20 mol % of a second monomer. preferably a salt of 2-acrylamido-2-methylpropane sulfonic acid, and, optionally a crosslinking agent. The conductive composition has a pH of about 7.0 or less.
대표청구항▼
What is claimed is: 1. A conductive composition comprising: about 33 wt % to about 68 wt % of a humectant or a mixture of humectants; about 1 wt % to about 8 wt % of an electrolyte or mixture of electrolytes; about 6 wt % to about 20 wt % of water; about 18 wt % to about 45 wt % of a copolymer cons
What is claimed is: 1. A conductive composition comprising: about 33 wt % to about 68 wt % of a humectant or a mixture of humectants; about 1 wt % to about 8 wt % of an electrolyte or mixture of electrolytes; about 6 wt % to about 20 wt % of water; about 18 wt % to about 45 wt % of a copolymer consisting essentially of, in polymerized form, about 80 mol % to about 95 mol % of a first monomer, in which the first monomer is a mixture of acrylic acid and one of more salts thereof, and about 5 mol % to 20 mol % of a second monomer, in which the second monomer is one of more monomers selected from CH2=CHC(O)XR, in which X is O or NH and R is an unsubstituted or substituted alkyl group of 1 to 5 carbon atoms; and in which the conductive composition has a pH of about 7.0 or less. 2. The conductive composition of claim 1 in which the copolymer is not crosslinked by a crosslinking agent. 3. The conductive composition of claim 2 in which the second monomer is a salt of 2-acrylamido-2-methylpropane sulfonic acid, and the pH of the conductive composition is 3.0 to 6.5. 4. The conductive composition of claim 3 in which the first monomer is a mixture of acrylic acid and sodium acrylate, and the second monomer is sodium 2-acrylamido-2-methylpropane sulfonate. 5. The conductive composition of claim 4 in which the composition comprises about 55 wt % to about 65 wt % of the humectant or the mixture of humectants and about 20 wt % to about 40 wt % of the copolymer, and the copolymer comprises, in polymerized form, about 85 mol % to about 95 mol % of the first monomer and about 5 mol % to 15 mol % of the second monomer. 6. The conductive composition of claim 5 in which the humectant is glycerol, sorbitol, or a mixture thereof, and the electrolyte is sodium chloride. 7. The conductive composition of claim 6 in which the composition meets ANSI/AAMI standard EC 12:2000, both before and after storage open to the atmosphere at 70° C. for 72 hr. 8. The conductive composition of claim 3 in which the composition comprises about 55 wt % to about 65 wt % of the humectant or the mixture of humectants and about 20 wt % to about 40 wt % of the copolymer; the copolymer comprises, in polymerized form, about 85 mol % to about 95 mol % of the first monomer and about 5 mol % to 15 mol % of the second monomer; and the composition meets ANSI/AAMI standard EC 12:2000, both before and after storage open to the atmosphere at 70° C. for 72 hr. 9. The conductive composition of claim 1 in which the polymer is crosslinked by a crosslinking agent. 10. The conductive composition of claim 9 in which the second monomer is a salt of 2-acrylamido-2-methylpropane sulfonic acid, and the pH of the conductive composition is 3.0 to 6.5. 11. The conductive composition of claim 10 in which the first monomer is a mixture of acrylic acid and sodium acrylate, and the second monomer is sodium 2-acrylamido-2-methylpropane sulfonate. 12. The conductive composition of claim 11 in which the composition comprises about 55 wt % to about 65 wt % of the humectant or the mixture of humectants and about 20 wt % to about 40 wt % of the copolymer, and the copolymer comprises, in polymerized form, about 85 mol % to about 95 mol % of the first monomer and about 5 mol % to 15 mol % of the second monomer. 13. The conductive composition of claim 12 in which the humectant is glycerol, sorbitol, or a mixture thereof, and the electrolyte is sodium chloride. 14. The conductive composition of claim 13 in which the composition meets ANSI/AAMI standard EC 12:2000, both before and after storage open to the atmosphere at 70° C. for 72 hr. 15. The conductive composition of claim 13 in which the composition comprises about 55 wt % to about 65 wt % of the humectant or the mixture of humectants and about 20 wt % to about 40 wt % of the copolymer; the copolymer comprises, in polymerized form, about 85 mol % to about 95 mol % of the first monomer and about 5 mol % to 15 mol % of the second monomer; and the composition meets ANSI/AAMI standard EC 12:2000, both before and after storage open to the atmosphere at 70° C. for 72 hr. 16. A biomedical electrode comprising: a substrate; and a layer of conductive composition on the substrate; in which the conductive composition comprises: about 33 wt % to about 68 wt % of a humectant or a mixture of humectants; about 1 wt % to about 8 wt % of an electrolyte or mixture of electrolytes; about 6 wt % to about 20 wt % of water; about 18 wt % to about 45 wt % of a copolymer consisting essentially of, in polymerized form, about 80 mol % to about 95 mol % of a first monomer, in which the first monomer is a mixture of acrylic acid and one of more salts thereof, and about 5 mol % to 20 mol % of a second monomer, in which the second monomer is one of more monomers selected from CH2═CHC(O)XR, in which X is O or NH and R is an unsubstituted or substituted alkyl group of 1 to 5 carbon atoms; and in which the conductive composition has a pH of about 7.0 or less. 17. The biomedical electrode of claim 16 in which the composition meets ANSI/AAMI standard EC 12:2000, both before and after storage open to the atmosphere at 70° C. for 72 hr. 18. The biomedical electrode of claim 17 in which the copolymer is not crosslinked by a crosslinking agent. 19. The biomedical electrode of claim 18 in which the second monomer is a salt of 2-acrylamido-2-methylpropane sulfonic acid, and the pH of the conductive composition is 3.0 to 6.5. 20. The biomedical electrode of claim 19 in which the first monomer is a mixture of acrylic acid and sodium acrylate, and the second monomer is sodium 2-acrylamido-2-methylpropane sulfonate. 21. The biomedical electrode of claim 20 in which the composition comprises about 55 wt % to about 65 wt % of the humectant or the mixture of humectants and about 20 wt % to about 40 wt % of the copolymer, and the copolymer comprises, in polymerized form, about 85 mol % to about 95 mol % of the first monomer and about 5 mol % to 15 mol % of the second monomer. 22. The biomedical electrode of claim 21 in which the humectant is glycerol, sorbitol, or a mixture thereof, and the electrolyte is sodium chloride. 23. The biomedical electrode of claim 22 additionally comprising a conductive interface electrically connected to the layer of conductive composition and adapted to be electrically connected to an item of external medical equipment. 24. The biomedical electrode of claim 19 in which the composition comprises about 55 wt % to about 65 wt % of the humectant or the mixture of humectants and about 20 wt % to about 40 wt % of the copolymer, and the copolymer comprises, in polymerized form, about 85 mol % to about 95 mol % of the first monomer and about 5 mol % to 15 mol % of the second monomer. 25. The biomedical electrode of claim 17 in which the polymer is crosslinked by a crosslinking agent. 26. The biomedical electrode of claim 25 in which the second monomer is a salt of 2-acrylamido-2-methylpropane sulfonic acid, and the pH of the conductive composition is 3.0 to 6.5. 27. The biomedical electrode of claim 26 in which the first monomer is a mixture of acrylic acid and sodium acrylate, and the second monomer is sodium 2-acrylamido-2-methylpropane sulfonate. 28. The biomedical electrode of claim 27 in which the composition comprises about 55 wt % to about 65 wt % of the humectant or the mixture of humectants and about 20 wt % to about 40 wt % of the copolymer, and the copolymer comprises, in polymerized form, about 85 mol % to about 95 mol % of the first monomer, about 5 mol % to 15 mol % of the second monomer, and about 0.01 wt % to about 1.0 wt % of a crosslinking agent or mixture of crosslinking agents. 29. The biomedical electrode of claim 28 in which the humectant is glycerol, sorbitol, or a mixture thereof, and the electrolyte is sodium chloride. 30. The biomedical electrode of claim 29 additionally comprising a conductive interface electrically connected to the layer of conductive composition and adapted to be electrically connected to an item of external medical equipment. 31. The biomedical electrode claim 25 in which the composition comprises about 55 wt % to about 65 wt % of the humectant or the mixture of humectants and about 20 wt % to about 40 wt % of the copolymer, and the copolymer comprises, in polymerized form, about 85 mol % to about 95 mol % of the first monomer and about 5 mol % to 15 mol % of the second monomer.
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