Repair of spinal annular defects and annulo-nucleoplasty regeneration
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/44
A61B-017/70
출원번호
UP-0746563
(2003-12-24)
등록번호
US-7763077
(2010-08-13)
발명자
/ 주소
Friedman, Craig D.
Datta, Arindam
출원인 / 주소
Biomerix Corporation
대리인 / 주소
Dippert, William H.
인용정보
피인용 횟수 :
28인용 특허 :
426
초록▼
The invention relates to the repair of spinal annular defects. An appartatus comprises a scaffold comprised of a biodurable, resiliently compressible, elastomeric reticulated composition to obliterate spinal/vertabral connective tissue defects, to obliterate spinal-annular nuclear tissue defects, an
The invention relates to the repair of spinal annular defects. An appartatus comprises a scaffold comprised of a biodurable, resiliently compressible, elastomeric reticulated composition to obliterate spinal/vertabral connective tissue defects, to obliterate spinal-annular nuclear tissue defects, and for spinal annulo-nucleoplasty regeneration. The apparatus comprises an at least partially cylindrical member.
대표청구항▼
We claim: 1. A method of treating spinal annular defects which comprise the steps of: (a) inserting an at least partially cylindrical apparatus comprising a scaffold comprised of a biodurable, resiliently compressible, elastomeric reticulated matrix into the lumen of a delivery means; (b) advancing
We claim: 1. A method of treating spinal annular defects which comprise the steps of: (a) inserting an at least partially cylindrical apparatus comprising a scaffold comprised of a biodurable, resiliently compressible, elastomeric reticulated matrix into the lumen of a delivery means; (b) advancing the distal tip of the delivery means into an opening in an annulus; (c) advancing the apparatus through the lumen into the opening; and (d) withdrawing the delivery means, whereby the apparatus expands into the opening. 2. The apparatus of method of claim 1, wherein the elastomeric matrix is hydrophobic. 3. The method of claim 1, wherein the elastomeric matrix comprises an elastomer selected from the group consisting of polycarbonate polyurethanes, polyester polyurethanes, polyether polyurethanes, polysiloxane polyurethanes, polyurethanes with mixed soft segments, polycarbonates, polyesters, polyethers, polysiloxanes, polyurethanes, and mixtures of two or more thereof. 4. The method of claim 3, wherein the elastomeric matrix comprises a polycarbonate polyurethane. 5. method of claim 3, wherein the elastomer is prepared by reacting a polyol component with an isocynanate component. 6. The method of claim 5, wherein the polyol component comprises a polycarbonate polyol, hydrocarbon polyol, polysiloxane polyol, poly(carbonate-co-hydrocarbon) polyol, poly(carbonate-co-siloxane) polyol, poly(hydrocarbon-co-siloxane) polyol, or mixtures thereof. 7. The method of claim 5, wherein the polyol component comprises a difunctional polycarbonate diol. 8. The method of claim 5, wherein the isocyanate component comprises tetramethylene diisocyanate, cyclohexane- 1,2-diisocyanate, cyclohexane-1,4-diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, methylene-bis-(p-cyclohexyl isocyanate), p-phenylene diisocyanate, 4,4′-diphenylmethane diisocyanate, 2,4′-diphenylmethane diisocyanate, 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, m-tetramethylxylene diisocyanate, or mixtures thereof. 9. The method of claim 5, wherein the isocyanate component comprises MDI, wherein the MDI is a mixture of at least about 5% by weight of 2,4′-MDI with the balance 4,4′-MDI. 10. The method of claim 1, wherein the elastomeric matrix comprises a polyurethane. 11. The method of claim 1, wherein the elastomeric matrix comprises a reticulated elastomeric matrix comprising a plurality of pores, the pores having an average diameter or other largest transverse dimension of at least about 20 μm. 12. The method of claim 11, wherein the pores have an average diameter or other largest transverse dimension of from about 20 μm to about 150 μm. 13. The method of claim 11, wherein the pores have an average diameter or other largest transverse dimension of from about 150 μm to about 250 μm. 14. The method of claim 11, wherein the pores have an average diameter or other largest transverse dimension of from about 250 μm to about 500 μm. 15. The method of claim 1, wherein, when the elastomeric matrix is compressed from a relaxed configuration to a first, compact configuration for delivery via a delivery-device, it expands to a second, working configuration, in vivo, at least about 80% claim of the size of the relaxed configuration in at least one dimension. 16. The method of claim 15, wherein the recovery properties of the elastomeric matrix are such that a dimension of the second, working configuration is within about 20% of a relaxed dimension of the relaxed configuration after compression to from about 50 to about 10% of the relaxed dimension. 17. The method of claim 1, wherein the elastomeric matrix has a compressive strength at 50% compression of from about 1 to about 500 psi, a tensile strength of from about 1 to about 500 psi, and an ultimate tensile elongation of at least about 46%. 18. The method of claim 1, wherein the elastomeric matrix has a compression set after 22 hours compression at about 25° C. to 25% of its thickness in one dimension of not more than about 20%. 19. The method of claim 1, wherein the reticulated elastomeric matrix is configured to permit cellular ingrowth and proliferation into the elastomeric matrix. 20. The method of claim 1, endoporously coating a reticulated elastomeric matrix with a coating material selected to encourage cellular ingrowth and proliferation. 21. The method of claim 1, wherein the coating material comprises a foamed coating of a biodegradable material, the biodegradable material comprising collagen, fibronectin, elastin, hyaluronic acid or mixtures thereof. 22. The method of claim 1, wherein the implantable device comprises a plurality of elastomeric matrices. 23. The method of claim 1, wherein the delivery means is a trocar, cannula, or catheter, with visual assistance through an endoscopic instrument. 24. The apparatus of claim 1, wherein the reticulated matrix comprises a polyurethane.
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