Method of regulating temperature of a composition for coating implantable medical devices
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B05D-003/02
B05B-007/16
출원번호
UP-0011365
(2004-12-13)
등록번호
US-7763308
(2010-08-13)
발명자
/ 주소
Chen, Yung-Ming
Bobson, Charles R.
LoPrete, John F.
출원인 / 주소
Advanced Cardiovascular Systems, Inc.
대리인 / 주소
Squire, Sanders & Dempsey, L.L.P.
인용정보
피인용 횟수 :
8인용 특허 :
40
초록▼
An applicator for applying a coating substance to an implantable medical device, such as a stent, is provided. The applicator comprises a nozzle and a temperature controller in communication with the nozzle for adjusting the temperature of the coating substance. A method of using the applicator is a
An applicator for applying a coating substance to an implantable medical device, such as a stent, is provided. The applicator comprises a nozzle and a temperature controller in communication with the nozzle for adjusting the temperature of the coating substance. A method of using the applicator is also provided.
대표청구항▼
What is claimed is: 1. A method of coating a stent, comprising: positioning a stent at a distance away from a nozzle; applying a coating composition from the nozzle to the stent, the coating composition including a substance capable of degrading with exposure to heat; and adjusting the temperature
What is claimed is: 1. A method of coating a stent, comprising: positioning a stent at a distance away from a nozzle; applying a coating composition from the nozzle to the stent, the coating composition including a substance capable of degrading with exposure to heat; and adjusting the temperature of the nozzle to heat the coating composition. 2. The method of claim 1, wherein the coating composition further includes a polymer dissolved in a solvent, and the substance capable of degrading with exposure to heat is a therapeutic substance. 3. The method of claim 1, additionally including rotating the stent about a longitudinal axis of the stent during the application of the coating composition. 4. The method of claim 1, wherein the coating composition is applied as atomized droplets. 5. The method of claim 1, wherein the temperature of the nozzle is adjusted prior to the application of the coating composition from the nozzle. 6. The method of claim 1, wherein the temperature of the nozzle is adjusted contemporaneously with the application of the coating composition from the nozzle. 7. The method of claim 1, wherein a thermal block is in thermal communication with the nozzle, the thermal block configured to adjust the temperature of the nozzle. 8. The method of claim 7, further comprising monitoring the temperature of the thermal block and making adjustments to the temperature of the thermal block based on the monitoring. 9. The method of claim 7, wherein the thermal block is positioned in close proximity to an orifice of the nozzle and circumscribes the nozzle. 10. The method of claim 1, wherein the temperature of the nozzle is adjusted to a temperature of about 35 degrees C. to about 40 degrees C. 11. The method of claim 1, wherein the temperature of the nozzle is adjusted to a temperature above 40 degrees C. 12. The method of claim 1, wherein the temperature of the nozzle is adjusted to a temperature above room temperature. 13. The method of claim 1, wherein the substance capable of degrading with exposure to heat is actinomycin D. 14. A method of coating a stent, comprising: positioning a stent on a support apparatus; spraying a coating composition from a nozzle to the stent positioned on the support apparatus, the coating composition including a heat sensitive substance; and adjusting the temperature of the nozzle to heat the coating composition. 15. The method of claim 14, wherein the coating composition further includes a polymer dissolved in a solvent, and the heat sensitive substance is a therapeutic substance. 16. The method of claim 14, wherein the temperature of the nozzle is adjusted to a temperature of about 35° C. to 40° C. 17. The method of claim 14, wherein the temperature of the nozzle is adjusted to a temperature above room temperature. 18. The method of claim 14, additionally including rotating the stent about a longitudinal axis of the stent during spraying of the coating composition from the nozzle to the stent. 19. The method of claim 14, wherein the coating composition is sprayed as atomized droplets. 20. The method of claim 14, wherein the temperature of the nozzle is adjusted prior to the spraying of the coating composition from the nozzle. 21. The method of claim 14, wherein the temperature of the nozzle is adjusted contemporaneously with the spraying of the coating composition from the nozzle. 22. The method of claim 14, wherein adjusting the temperature of the nozzle includes activating a temperature controller coupled to the nozzle to heat the coating composition as the coating composition passes through the nozzle. 23. The method of claim 22, wherein the temperature controller is configured to heat the coating composition only at a concentrated area of the nozzle to prevent prolonged exposure of the coating composition to the heat. 24. The method of claim 22, further comprising monitoring the temperature of the temperature controller, and optionally, adjusting the temperature of the temperature controller based on the monitoring step. 25. The method of claim 22, wherein the temperature controller is activated to maintain the temperature of the coating composition at a constant temperature during the spraying process. 26. The method of claim 22, wherein the temperature controller is configured to change the temperature of the coating composition before the coating composition passes through an orifice of the nozzle and not after the composition passes through the orifice of the nozzle and in transit onto the stent. 27. The method of claim 14, wherein the temperature of the nozzle is adjusted by a thermal block in intimate, direct contact with the nozzle and circumscribing the nozzle. 28. The method of claim 27, further comprising monitoring the temperature of the thermal block and making adjustments based on the monitoring step. 29. The method of claim 27, wherein the thermal block is positioned in close proximity to an orifice of the nozzle. 30. The method of claim 14, wherein the temperature of the nozzle is adjusted to a temperature above 40 degrees C. 31. The method of claim 14, wherein the heat sensitive substance is actinomycin D.
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이 특허에 인용된 특허 (40)
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