The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a phospholipid into a fluid composition including a lens-forming material in an amount sufficient t
The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a phospholipid into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the phospholipids.
대표청구항▼
What is claimed is: 1. A method for producing a contact lens, comprising: the steps of: (1) introducing a fluid composition into a mold for making a contact lens, wherein the fluid composition comprises a lens-forming material and a PEG-ylated phosphatidyl ethanolamines, wherein the lens-forming ma
What is claimed is: 1. A method for producing a contact lens, comprising: the steps of: (1) introducing a fluid composition into a mold for making a contact lens, wherein the fluid composition comprises a lens-forming material and a PEG-ylated phosphatidyl ethanolamines, wherein the lens-forming material is crosslinkable and/or polymerizable by actinic radiation or by heating; (2) crosslinking/polymerizing the lens-forming material in the mold to form a lens having a polymer matrix, wherein at least part of the PEG-ylated phosphatidyl ethanolamines migrates to the interface between the mold and the polymer matrix of the formed lens; and (3) separating the mold, wherein the PEG-ylated phosphatidyl ethanolamines is present in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the PEG-ylated phosphatidyl ethanolamines. 2. The method of claim 1, where the PEG-ylated phosphatidyl ethanolamines is at least one member selected from the group consisting of PEG-ylated dipalmitoyl phosphatidylethanolamine (DPPE-PEG), PEG-ylated palmitoyloleoyl phosphatidylethanolamine (POPE-PEG), PEG-ylated dioleoyl phosphatidylethanolamine (DOPE-PEG) and PEG-ylated distearoyl phosphatidylethanolamine (DSPE-PEG). 3. The method of claim 1, where the PEG-ylated phosphatidyl ethanolamines is PEG-ylated distearoyl phosphatidylethanolamine (DSPE-PEG). 4. The method of claim 1, wherein the fluid composition comprises from 0.5% to 10% PEG-ylated phosphatidyl ethanolamines. 5. The method of claim 4, wherein the fluid composition comprises from 1.0% to 6.0% PEG-ylated phosphatidyl ethanolamines. 6. The method of claim 5, wherein the fluid composition comprises from 1.5% to 4.0% PEG-ylated phosphatidyl ethanolamines. 7. The method of claim 1, wherein the lens-forming material comprises at least one prepolymer. 8. The method of claim 7, wherein the prepolymer is a silicone-containing prepolymer. 9. The method of claim 8, wherein the silicone-containing prepolymer is capable of forming, in the absence of any monomer and/or crosslinking agent, a silicone hydrogel contact lens which has at least one property selected from the group consisting of an apparent oxygen permeability of at least 40 barrers, an Ionoflux Diffusion Coefficient, D, of greater than about 1.5×10−6 mm2/min, an elastic modulus of from about 0.2 MPa to about 2.0 MPa, and a water content of from about 15% to about 80% by weight when fully hydrated. 10. The method of claim 9, wherein the prepolymer is a water-soluble silicone-free prepolymer. 11. The method of claim 1, wherein the lens-forming material comprises at least one prepolymer with two or more thiol groups or with two or more ene-containing groups. 12. The method of claim 1, wherein the fluid composition comprises at least one components selected from the group consisting of a polymerization initiator, a visibility tinting agent, a UV-blocking (absorbing) agent, a photosensitizer, an antimicrobial agent, a bioactive agent, a mold releasing agent, and a leachable lubricant. 13. The method of claim 1, wherein the step of crosslinking and/or polymerizing is performed under a spatial limitation of actinic radiation to form a contact lens having a first surface, an opposite second surface, and an edge, wherein the mold is a reusable mold having two molding surfaces, wherein the first and second surfaces are defined by the two molding surface, and the edge is defined by the spatial limitation of actinic radiation. 14. A method for improving quality and production yield of contact lenses, comprising the steps of: adding a PEG-ylated phosphatidyl ethanolamines into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the PEG-ylated phosphatidyl ethanolamines, wherein the lens-forming material is crosslinkable and/or polymerizable by actinic radiation or by heating in a mold to form a contact lens having a polymer matrix.
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