Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/70
A61B-017/03
A61F-002/00
A61F-002/82
A61F-013/00
A61K-047/30
A61L-031/04
출원번호
UP-0406791
(2006-04-19)
등록번호
US-7780980
(2010-09-13)
발명자
/ 주소
Sawhney, Amarpreet S.
출원인 / 주소
Incept, LLC
대리인 / 주소
Dardi & Herbert, PLLC
인용정보
피인용 횟수 :
18인용 특허 :
72
초록▼
Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and to affect sealing, plugging, or a
Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and to affect sealing, plugging, or augmentation of tissue, defects in tissue, or of organs. The hydrogel polymers may deliver therapeutic entities by controlled release at the site. Methods to form useful devices from such polymers, and to implant the devices are provided.
대표청구항▼
The invention claimed is: 1. A method of preventing bleeding via a percutaneous puncture site comprising: providing a hydrogel article in a substantially deswollen state preformed as a rolled sheet; deploying the hydrogel article into the percutaneous puncture site; and allowing the hydrogel articl
The invention claimed is: 1. A method of preventing bleeding via a percutaneous puncture site comprising: providing a hydrogel article in a substantially deswollen state preformed as a rolled sheet; deploying the hydrogel article into the percutaneous puncture site; and allowing the hydrogel article to hydrate and expand within the puncture site to prevent bleeding via the percutaneous puncture site. 2. The method of claim 1, wherein the hydrogel article is formed from a freeze dried hydrogel. 3. The method of claim 1, wherein the expansion of the hydrogel article anchors the hydrogel article within the percutaneous puncture site. 4. The method of claim 1, wherein the hydrogel article is bioabsorbable. 5. The method of claim 1, wherein the hydrogel article is delivered to the puncture site via a sheath. 6. The method of claim 1, wherein the hydrogel article is formed as a porous structure so as to accelerate the rate of expansion of the hydrogel article within the puncture site. 7. The method of claim 1, wherein the hydrogel article comprises a sterilized pharmaceutically acceptable covalently crosslinked hydrogel polymerized from at least one synthetic hydrophilic polyethylene glycol macromer. 8. The method of claim 1, wherein the hydrogel article has an outer diameter of no more than 1.5 mm. 9. The method of claim 1, wherein the hydrogel article is biodegradable. 10. A method for closure of a percutaneous puncture site, comprising: positioning a sheath through a puncture wound to provide access to an artery; removing the sheath from the puncture wound after completing a procedure; introducing a bioabsorbable, freeze dried hydrogel comprising a preformed rolled sheet into the puncture wound via a tubular device; exposing the hydrogel to fluids within the puncture wound, the hydrogel hydrating and expanding within the puncture wound to seal the puncture wound. 11. The method of claim 10, wherein the hydrogel comprises pores formed during the freeze drying process. 12. The method of claim 10, wherein the puncture wound communicates with a femoral artery. 13. The method of claim 10, wherein the hydrogel article comprises a sterilized pharmaceutically acceptable covalently crosslinked hydrogel polymerized from at least one synthetic hydrophilic polyethylene glycol macromer. 14. The method of claim 10, wherein the hydrogel is biodegradable.
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