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Compositions and methods for the treatment and prevention of hyperproliferative diseases 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/395
출원번호 UP-0261935 (2005-10-28)
등록번호 US-7794713 (2010-10-04)
발명자 / 주소
  • Sabbadini, Roger A.
  • Cavalli, Amy L.
  • Garland, William A.
출원인 / 주소
  • Lpath, Inc.
대리인 / 주소
    BioTechnology Law Group
인용정보 피인용 횟수 : 0  인용 특허 : 246

초록

Monotherapies and combination therapies for treating hyperproliferative disorders are described, as are compositions for performing such methods.

대표청구항 ▼

What is claimed is: 1. A method for treating an S1P-associated hyperproliferative disease associated with aberrant cardiac remodeling, comprising administering to a mammal known or suspected to suffer therefrom a therapeutically effective amount of an anti-S1P antibody to lower the effective concen

이 특허에 인용된 특허 (246)

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  • Carney Ronald E. (Gurnee IL) McAlpine James B. (Libertyville IL), Fortimicins AM and AP derivatives.
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  • Rutter William J. (San Francisco CA) Santi Daniel V. (San Francisco CA), General method for producing and selecting peptides with specific properties.
    상세보기
  • Chen Hao (Adelphia MD) Radmer Richard (Baltimore MD), Generation and screening of synthetic drug libraries.
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  • Kucherlapati Raju ; Jakobovits Aya ; Klapholz Sue ; Brenner Daniel G. ; Capon Daniel J., Generation of Xenogenetic antibodies.
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  • Collins John,DEX ; Rottgen Peter,DEX, Generation of diversity in combinatorial libraries.
    상세보기
  • Kucherlapati Raju ; Jakobovits Aya ; Kalpholz Sue ; Brenner Daniel G. ; Capon Daniel J., Generation of xenogeneic antibodies.
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  • Iwasaki Keiji (Kawasaki JPX) Iwashita Yuji (Kawasaki JPX) Okami Taketoshi (Yokohama JPX), Hemoglobin combined with a poly(alkylene oxide).
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  • Boguslaski Robert C. (Elkhart IN) Carrico Robert J. (Bremen IN) Christner James E. (Ann Arbor MI), Heterogenous specific binding assay employing a cycling reactant as label.
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  • Kucherlapati Raju ; Jakobovits Aya ; Brenner Daniel G. ; Capon Daniel J. ; Klapholz Sue, Human antibodies derived from immunized xenomice.
    상세보기
  • Kucherlapati Raju ; Jakobovits Aya ; Klapholz Sue ; Brenner Daniel G. ; Capon Daniel J., Human antibodies derived from immunized xenomice.
    상세보기
  • Barbas, III,Carlos F.; Rader,Christoph, Humanization of murine antibody.
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  • Goldstein,Neil I.; Giorgio,Nicholas A.; Jones,Steven Tarran; Saldanha,Jose William, Humanized anti-EGF receptor monoclonal antibody.
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  • Lin Augustine Y., Humanized antibodies and uses thereof.
    상세보기
  • Co Man Sung ; Tso J. Yun, Humanized antibodies reactive with GPIIB/IIIA.
    상세보기
  • Co Man Sung, Humanized antibodies reactive with L-selectin.
    상세보기
  • Vasquez Maximiliano ; Landolfi Nicholas F. ; Tsurushita Naoya ; Queen Cary L., Humanized antibodies to .gamma.-interferon.
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  • Philip R. Tempest GB; William J. Harris GB; Frank J. Carr GB, Humanized antibodies to Fc receptors for immunoglobulin G on human mononuclear phagocytes.
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  • Wayne A. Marasco ; Joyce Lavecchio ; Abner Mhashilkar ; Urban Ramstedt ; David Ring ; Bridget Eberhardt ; Julie Porter-Brooks, Humanized antibody and uses thereof.
    상세보기
  • Queen Cary L. (Los Altos CA) Co Man Sung (Cupertino CA) Schneider William P. (Mountain View CA) Landolfi Nicholas F. (Milpitas CA) Coelingh Kathleen L. (San Francisco CA) Selick Harold E. (Belmont CA, Humanized immunoglobulins.
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  • Queen Cary L. (Los Altos CA) Selick Harold E. (Belmont CA), Humanized immunoglobulins.
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  • Queen Cary L. (Los Altos CA) Selick Harold E. (Belmont CA), Humanized immunoglobulins.
    상세보기
  • Queen Cary L. ; Selick Harold E., Humanized immunoglobulins and methods of making the same.
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  • Richardson Kenneth (Canterbury GB2) Plews Rhona M. (Canterbury GB2) Wright James R. (Deal GB2), Hydroxyalkyl derivatives of aminoglycoside antibiotics.
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  • Bertoglio-Matte Jacques H. (Seattle WA), Immediate ligand detection assay.
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  • Ladner Robert C. (Ijanisville MD) Bird Robert E. (Rockville MD) Hardman Karl (Chevy Chase MD), Immunoaffinity purification methods using single polypeptide chain binding molecules.
    상세보기
  • Ladner Robert C. (Ijamsville MD) Bird Robert E. (Rockville MD) Hardman Karl (Chevy Chase MD), Immunoassay methods using single polypeptide chain binding molecules.
    상세보기
  • David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
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  • Ladner Robert C. (Ijamsville MD) Bird Robert E. (Rockville MD) Hardman Karl (Chevy Chase MD), Immunotheraphy using single chain polypeptide binding molecules.
    상세보기
  • Goroff Diana K. (Chevy Chase MD), In-vitro method for producing antigen-specific human monoclonal antibodies.
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  • Co Man Sung ; Scheinberg David A. ; Queen Cary L., Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region.
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  • Collum Paulette (Zion IL), Isofortimicin.
    상세보기
  • Umezawa Hamao (Tokyo JPX) Kondo Shinichi (Yokohama JPX), Kanamycin C derivatives.
    상세보기
  • Takaya, Takao; Yasuda, Nobuyoshi; Tsutsumi, Hideo; Matsuda, Keiji, Kasugamycin derivatives, pharmaceutical compositions and method of use.
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  • Stracher Alfred ; Kesner Leo, Liposome preferentially traveling to cardiac and skeletal muscles.
    상세보기
  • Ryan, Patrick J.; Davis, Michael A.; Melchior, Donald L., Liposomes containing modified cholesterol for organ targeting.
    상세보기
  • Woodle Martin C. (Menlo Park CA) Martin Francis J. (San Francisco CA) Yau-Young Annie (Los Altos CA) Redemann Carl T. (Walnut Creek CA), Liposomes with enhanced circulation time.
    상세보기
  • Litman David J. (Palo Alto CA) Harel Zvi (Stanford CA) Ullman Edwin F. (Atherton CA), Macromolecular environment control in specific receptor assays.
    상세보기
  • Sarnoff Stanley J. (Bethesda MD), Method and apparatus for initiating reperfusion treatment by an unattended individual undergoing heart attack symptoms.
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  • Burton James A. (Amesbury MA) Hoop ; Jr. Bernard (Wakefield MA), Method and apparatus for ligand detection.
    상세보기
  • Mather Jennie P. (Millbrae CA) Tsao Mary C. (Burlingame CA), Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins.
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  • Carter, Paul J.; Presta, Leonard G., Method for making humanized antibodies.
    상세보기
  • Paul J. Carter ; Leonard G. Presta, Method for making humanized antibodies.
    상세보기
  • Hiatt Andrew C. ; Ma Julian K.-C.,GBXITX SE231PE ; Lehner Thomas,GBXITX EN40LL ; Mostov Keith E., Method for producing immunoglobulins containing protection proteins in plants and their use.
    상세보기
  • Umezawa ; Hamao ; Kondo ; Shinichi, Method for production of kanamycin C and its derivatives.
    상세보기
  • Igarashi Yasuyuki (Seattle WA) Yatomi Yutaka (Seattle WA) Ohta Hideki (Seattle WA) Hakomori Sen-Itiroh (Mercer Island WA), Method for quantifying sphingosine and for diagnosing platelet activation.
    상세보기
  • Furuno Kouji (Kokubunji JA) Okazaki Akira (Oyama JA) Matsubara Syuzo (Fuchu JA) Shiba Motoharu (Omiya JA) Shioya Akitoshi (Kawagoe JA), Method for reducing side effects of aminoglycoside antibiotics and composition therefor.
    상세보기
  • Gado Istvan (Budapest HUX) Jekkel nee Bokany Antonia (Budapest HUX) Szvoboda Gyrgy (Budapest HUX) Jarai Miklos (Budapest HUX) Piukovich Sandor (Budapest HUX) Istvan Sandor (Szentendre HUX), Method for the preparation of antibiotic sisomicin.
    상세보기
  • Jarai Miklos (Budapest HUX) Piukovich Sandor (Budapest HUX) Istvan Sandor (Szentendre HUX) Gado Istvan (Budapest HUX) Szell Valeria (Budapest HUX) Barta Istvan (Budapest HUX), Method for the production of sisomicin.
    상세보기
  • Tabas, Ira; Schissel, Scott L.; Williams, Kevin Jon, Method for treating a subject suffering from conditions associated with an extracellular zinc sphingomyelinase.
    상세보기
  • Isner Jeffrey M., Method for treating ischemic tissue.
    상세보기
  • Daniels Peter J. L. (Cedar Grove NJ) Marquez Joseph A. (Montclair NJ), Method of isolating gentamicin C2a.
    상세보기
  • Light Susan ; Queen Cary, Method of preventing acute rejection following solid organ transplantation.
    상세보기
  • Carney Ronald E. (Gurnee IL) Martin Jerry R. (Waukegan IL) McAlpine James B. (Libertyville IL) Tadanier John S. (Waukegan IL), Method of producing 2-deoxyfortimicin A.
    상세보기
  • McAlpine James B. (Libertyville IL) Carney Ronald E. (Gurnee IL), Method of producing 2-epi-fortimicin A.
    상세보기
  • Kloss John (Gurnee IL) Nadzan Alex M. (Gurnee IL), Method of producing 3-O-demethylfortimicin B,4-N-alkylfortimicin B derivatives and related aminoglycoside antibiotics.
    상세보기
  • Borrebaeck Carl (Lund SEX) Danielsson Lena (Lund SEX) Moller Susanna (Lund SEX), Method of producing human monoclonal antibodies and kit therefor.
    상세보기
  • Ashby Matthew (San Aselmo CA) Rine Jasper (Moraga CA), Methods for drug screening.
    상세보기
  • Gold Larry (Boulder CO) Tuerk Craig (Boulder CO), Methods for identifying nucleic acid ligands.
    상세보기
  • Whitlow Marc D. ; Wood James F. ; Hardman Karl D. ; Bird Robert E. ; Filpula David ; Rollence Michele, Methods for producing multivalent antigen-binding proteins.
    상세보기
  • Gallop Mark A. (Los Altos CA) Murphy Martin A. (Mountain View CA), Methods for synthesizing diverse collections of pyrrolidine compounds.
    상세보기
  • Weinstein Marvin Joseph (East Brunswick NJ) Daniels Peter John Lovell (Cedar Grove NJ) Wagman Gerald Howard (East Brunswick NJ) Testa Raymond Thomas (Verona NJ), Methods for the preparation of semi-synthetic aminocyclitol aminoglycoside antibiotics.
    상세보기
  • Holmes Christopher P. (Sunnyvale CA), Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof.
    상세보기
  • Mandeville Rosemonde,CAX ; Popkov Mikhail,CAX, Methods of generating novel peptides.
    상세보기
  • Wei Yong (Branchburg NJ) Mayhew Eric (Monmouth Junction NJ) Ahmad Imran (Plainsboro NJ) Janoff Andrew S. (Yardley PA), Methods of treatment using pharmaceutically active ceramide-related compositions.
    상세보기
  • Chang Chung Nan ; Landolfi Nicholas F. ; Martin Ulrich,DEX, Monoclonal antibodies specific for the platelet derived growth factor .beta. receptor and methods of use thereof.
    상세보기
  • Garrard Lisa J. ; Henner Dennis J. ; Bass Steven ; Greene Ronald ; Lowman Henry B. ; Wells James A. ; Matthews David J., Monovalent phage display.
    상세보기
  • Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Morpholino-subunit combinatorial library and method.
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  • Boss Michael A. (Slough GBX) Kenten John H. (High Wycombe GBX) Emtage John S. (High Wycombe GBX) Wood Clive R. (Near Fordingbridge GBX), Multichain polypeptides or proteins and processes for their production.
    상세보기
  • Whitlow Marc D. ; Wood James F. ; Hardman Karl D. ; Bird Robert E. ; Filpula David ; Rollence Michele, Multivalent antigen-binding proteins.
    상세보기
  • Whitlow Marc D. ; Wood James F. ; Hardman Karl D. ; Bird Robert E. ; Filpula David ; Rollence Michele, Multivalent antigen-binding proteins.
    상세보기
  • Tso J. Yun ; Cole Michael S. ; Anasetti Claudio, Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same.
    상세보기
  • Davis Frank F. (19 Farmingdale Rd. East Brunswick NJ 08816) Van Es Theodorus (313 Overbrook Rd. Piscataway NJ 08854) Palczuk Nicholas C. (45 W. Franklin St. Bound Brook NJ 08805), Non-immunogenic polypeptides.
    상세보기
  • Mallams Alan K. (West Orange NJ) Davies David Huw (Macclesfield EN), Novel 4,6-di-O-(aminoglycosyl)-2-deoxystreptamine, method for its manufacture, method for its use as an antiprotozoal ag.
    상세보기
  • Igarashi Kikuo (Itami JPX) Honma Tsunetoshi (Ikoma JPX), Novel aminoglycoside derivatives.
    상세보기
  • Igarashi Kikuo (Itami JPX) Irisawa Junji (Nishinomiya JPX) Honma Tsunetoshi (Ikoma JPX), Novel aminoglycoside derivatives.
    상세보기
  • Igarashi Kikuo (Itami JPX) Sugawara Tamio (Mino JPX), Novel aminoglycoside derivatives.
    상세보기
  • Mangia Alberto (Milan ITX) Giobbio Vicenzo (Turin ITX) Ornato Giorgio (Ivrea ITX), Novel process for the synthesis of amikacin.
    상세보기
  • Magerlein Barney J. (Portage MI), O-Glycoside ortho esters of neamine containing compounds.
    상세보기
  • Cook Phillip D. (Carlsbad CA) Kiely John (San Diego CA) Sprankle Kelly (Vista CA), Peptide nucleic acid combinatorial libraries and improved methods of synthesis.
    상세보기
  • Mulligan-Kehoe Mary Jo (Springfield VA), Phage-display of immunoglobulin heavy chain libraries.
    상세보기
  • Wei Yong (Branchburg NJ) Mayhew Eric (Monmouth Junction NJ) Ahmad Imran (Plainsboro NJ) Janoff Andrew S. (Yardley PA), Pharmaceutically active ceramide-related compounds.
    상세보기
  • Shimizu Kimihiro (Yoshikawa JPX) Nakahara Tsuguji (Tokyo JPX) Kinoshita Taketoshi (Koshigaya JPX) Takatsuka Jun (Kawasaki JPX) Igarashi Michiko (Musashino JPX), Plasminogen activator derivatives.
    상세보기
  • Queen Cary L. (Los Altos CA) Schneider William P. (Mountain View CA) Selick Harold E. (Belmont CA), Polynucleotides encoding improved humanized immunoglobulins.
    상세보기
  • Cron Martin J. (Fayetteville NY) Keil John G. (Manlius NY) Lin Jeng S. (Clay NY) Ruggeri Mariano (Liverpool NY) Walker Derek (Jamesville NY), Preparation of 1-N-[wa 상세보기
  • Cron Martin J. (Fayetteville NY) Keil John G. (Manlius NY) Lin Jeng S. (Clay NY) Ruggeri Mariano V. (Liverpool NY) Walker Derek (Jamesville NY), Preparation of 1-N-[wa 상세보기
  • Holton Robert A. (Tallahassee FL), Preparation of substituted isoserine esters using b 상세보기
  • Ross ; Barry C., Process for .omega.-amino-2-hydroxyalkyl derivatives of aminoglycoside antibiotics.
    상세보기
  • Mallams ; Alan K. ; Davies ; David Huw, Process for preparing 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and novel 1-epimers and 1-N-alkyl derivatives produ.
    상세보기
  • Giobbio Vincenzo (Turin ITX) Ambrosini Leonardo (Bergamo ITX), Process for preparing amikacin.
    상세보기
  • Igarashi Kikuo (Itami JPX) Sugawara Tamio (Mino JPX), Process for preparing aminoglycoside derivatives.
    상세보기
  • Tann Chou-Hong (Berkeley Heights NJ) Thiruvengadam Tiruvettipuram K. (Edison NJ) Chiu John S. (Parsippany NJ) Colon Cesar (Rahway NJ) Green Michael D. (Paterson NJ), Process for preparing isepamicin.
    상세보기
  • Rosenbrook ; Jr. William (Libertyville IL), Process for producing 3-O-demethylaminoglycoside and novel 3-O-demethylfortimicin derivatives.
    상세보기
  • Oka Yoshihiko (Kawagoe JPX) Ishida Hitoshi (Ageo JPX) Morioka Moto (Niiza JPX) Numusaki Yoso (Ageo JPX) Yamafuji Tsutomu (Tokyo JPX) Osono Takashi (Tokyo JPX) Umezawa Hamao (Tokyo JPX), Process for production of aminoglycoside antibiotics.
    상세보기
  • Nagabhushan Tattanahalli Lakshminarayan (Parsippany NJ), Process for the manufacture of 6′-N-alkyl derivatives of sisomicin and verdamicin; novel intermediates useful therein,.
    상세보기
  • Schreiber Richard Henry (Canastota NY) Keil John Gerard (Manlius NY), Process for the preparation of 1-[L-(-)-ga 상세보기
  • Dall\Asta Leone (Pavia ITX) Garegnani Eugenio (Marcallo Con Casone ITX), Process for the preparation of amikacin precursors.
    상세보기
  • Dall\Asta Leone (Pavia ITX) Garegnani Eugenio (Marcallo con Casone ITX), Process for the preparation of amikacin precursors.
    상세보기
  • Stadler, Peter; Koebernick, Wolfgang; Samaan, Samir; Gau, Wolfgang, Process for the preparation of purified aminoglycoside antibiotics.
    상세보기
  • Horii Satoshi (Osaka JA) Nogami Ikuo (Kyoto JA) Hasegawa Toru (Kawani JA) Yoneda Masahiko (Uozakinaka JA), Process for the preparation of xylostasin.
    상세보기
  • Mangia Alberto,ITX, Process for the synthesis of amikacin.
    상세보기
  • Nagabhushan Tattanahalli L. (Parsippany NJ) Turner William N. (Bloomfield NJ) Cooper Alan (Parsippany NJ), Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used t.
    상세보기
  • Umezawa Hamao (Tokyo JPX) Umezawa Sumio (Tokyo JPX) Tsuchiya Tsutomu (Yokohama JPX) Takagi Yasushi (Yokohama JPX) Jikihara Tomo (Kawasaki JPX), Production of a selectively protected N-acylated derivative of an aminoglycosidic antibiotic.
    상세보기
  • Surani Azim M. (Cambridge GB3) Neuberger Michael S. (Cambridge GB3) Bruggemann Marianne (Cambridge GB3), Production of antibodies from transgenic animals.
    상세보기
  • Hoogenboom Hendricus R. J. M. (Cambridge GBX) Baier Michael (Frankfurt DEX) Jespers Laurent S. A. T. (Tervuren BEX) Winter Gregory P. (Cambridge GBX), Production of chimeric antibodies - a combinatorial approach.
    상세보기
  • Fell H. Perry (Redmond WA) Folger Bruce Kim R. (Seattle WA), Production of chimeric antibodies by homologous recombination.
    상세보기
  • Arcamone ; Federico ; Cassinelli ; Giuseppe, Protected pseudotrisaccharide intermediate for paromomycin and neomycin derivatives.
    상세보기
  • Cleveland William L. (New York NY) Erlanger Bernard F. (Whitestone NY), Protein-free culture medium.
    상세보기
  • Acevedo Oscar L. (San Diego CA) Hebert Normand (San Marcos CA), Pyrrolidine-containing monomers and oligomers.
    상세보기
  • Winter Gregory P. (Cambridge GBX), Recombinant altered antibodies and methods of making altered antibodies.
    상세보기
  • Cabilly Shmuel (Monrovia CA) Heyneker Herbert L. (Burlingame CA) Holmes William E. (Pacifica CA) Riggs Arthur D. (La Verne CA) Wetzel Ronald B. (San Francisco CA), Recombinant immunoglobin preparations.
    상세보기
  • Weng Litai (Mountain View CA) Gibbons Iam (Menlo Park CA), Reducing interference in ligand-receptor binding assays.
    상세보기
  • Gamble, Jennifer; Vadas, Mathew; Xia, Pu; Barter, Phillip; Rye, Kerry-Anne; Wattenberg, Brian; Pitson, Stuart, Screening method for an agent having an effect on a sphingosine kinase signaling pathway.
    상세보기
  • Carney Ronald E. (Gurnee IL) McAlpine James B. (Libertyville IL) Perun Thomas J. (Libertyville IL), Seldomycin factor 5 derivative.
    상세보기
  • Carney Ronald E. (Gurnee IL) McAlpine James B. (Libertyville IL), Seldomycin factor 5 derivatives.
    상세보기
  • Petersen Uwe (Leverkusen DEX) Voss Eckart (Cologne DEX) Stadler Peter (Haan DEX), Selectively protected 1-N-(w 상세보기
  • Weinstein Marvin J. (East Brunswick NJ) Daniels Peter J. L. (Cedar Grove NJ) Wagman Gerald H. (East Brunswick NJ) Testa Raymond (Verona NJ), Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof.
    상세보기
  • Zhao Min,CNX ; Fan Jin,CNX ; Liu Jun,CNX ; Hu Xiaoling,CNX ; Fan Minqi,CNX, Semisynthetic 1-N-ethylgentamicin C.sub.1a and method for its preparation.
    상세보기
  • Cartaya Oscar A. (125 Pleasant St. ; Apt. #401 Brookline MA 02146), Serum-free cell culture media.
    상세보기
  • Baker, Paul E., Serum-free cell culture medium and process for making same.
    상세보기
  • Kumar Sudhir (18901 Springfield Flossmoor IL 60422), Serum-free, synthetic, completely chemically defined tissue culture media.
    상세보기
  • Ladner Robert C. (Ijamsville MD) Bird Robert E. (Rockville MD) Hardman Karl (Chevy Chase MD), Single polypeptide chain binding molecules.
    상세보기
  • Ladner Robert C. (Ijamsville MD) Bird Robert E. (Rockville MD) Hardman Karl (Chevy Chase MD), Single polypeptide chain binding molecules.
    상세보기
  • Petersen Uwe (Leverkusen DEX) Stadler Peter (Haan DEX) Lockhoff Oswald (Leverkusen DEX) Zeiler Hans-Joachim (Velbert DEX) Metzger Karl G. (Wuppertal DEX), Sisomicin compounds.
    상세보기
  • Petersen Uwe (Leverkusen DEX) Metzger Karl G. (Wuppertal DEX) Zeiler Hans-Joachim (Velbert DEX) Stadler Peter (Haan DEX) Voss Eckart (Cologne DEX), Sisomicin derivatives, processes for their production and their medicinal use.
    상세보기
  • Ellman Jonathan A. (Berkeley CA), Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support.
    상세보기
  • Liotta, Dennis C.; Merrill, Jr., Alfred H.; Keane, Thomas E.; Bhalla, Kapil N.; Schmelz, Eva M, Sphingolipid derivatives and their methods of use.
    상세보기
  • Rosenkrantz Bernard E. (Bloomfield NJ) Stupak Elliot (West Caldwell NJ), Stabilized aminoglycoside antibiotic formulations.
    상세보기
  • Hines, Jacqueline; Carpenter, Charles; Solie, Leland P., Surface-acoustic-wave pressure sensor and associated methods.
    상세보기
  • Kavadias Gerry (St-Lambert CA) Belleau Bernard (Westmount CA), Synthesis of cis-1,4-cyclohexadiene dioxide.
    상세보기
  • Canas-Rodriquez Antonio (8 Saint Martin\s Pl. Canterbury GB2 CT1 1QD), Synthetic aminoglycosides.
    상세보기
  • Regen Steven L. (Milwaukee WI), Synthetic phosphatidyl cholines useful in forming liposomes.
    상세보기
  • Segal David M. (Rockville MD) Perez Pilar (Bethesda MD), Target specific cross-linked heteroantibodies.
    상세보기
  • Brown Scott M. (San Diego CA), Tissue factor based prothrombin time reagent.
    상세보기
  • Kavadias ; Gerry ; Belleau ; Bernard R., Total synthesis of 2,5-dideoxystreptamines.
    상세보기
  • Krimpenfort Paulus J. A. (Amsterdam NLX) Berns Antonius J. M. (Spaarndam NLX), Transgenic mice depleted in a mature lymphocytic cell-type.
    상세보기
  • Lonberg Nils ; Kay Robert M., Transgenic non-human animals capable of producing heterologous antibodies.
    상세보기

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