Microencapsulation of oxygen or water sensitive materials
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/50
B01J-013/00
A61J-003/07
출원번호
UP-0654422
(2003-09-04)
등록번호
US-7794836
(2010-10-04)
발명자
/ 주소
Vasishtha, Niraj
Schlameus, Herman W.
Barlow, Darren E.
출원인 / 주소
Southwest Research Institute
대리인 / 주소
Grossman, Tucker et al.
인용정보
피인용 횟수 :
13인용 특허 :
13
초록▼
A barrier coating composition includes a polymer material and a structuring agent dispersed in said polymer material, wherein the structuring agent decreases oxygen or water permeability through the polymer material. The barrier coating composition can be used to coat a core component, which can be
A barrier coating composition includes a polymer material and a structuring agent dispersed in said polymer material, wherein the structuring agent decreases oxygen or water permeability through the polymer material. The barrier coating composition can be used to coat a core component, which can be oxygen or water sensitive, to form a microencapsulated material. The microencapsulated material can be formed by microencapsulation methods, which include atomization or coacervation methods, including forming an oil emulsion of an oil phase and an aqueous phase, the oil phase including the core component and the aqueous phase including the polymer material, adding the structuring agent to one of the oil phase and the aqueous phase, mixing the oil emulsion to form desired particle sizes of the core component, forming the shell component around the core component to form the microencapsulated material, and extracting the formed microencapsulated material from the oil emulsion.
대표청구항▼
What is claimed is: 1. A microencapsulated material, comprising: a core component, wherein said core component is at least one of oxygen sensitive or water sensitive; a shell component encapsulating said core component, wherein said shell component comprises a polymer material and a structuring age
What is claimed is: 1. A microencapsulated material, comprising: a core component, wherein said core component is at least one of oxygen sensitive or water sensitive; a shell component encapsulating said core component, wherein said shell component comprises a polymer material and a structuring agent having an average particle size from about 0.1 to about 1 μm at a level of about 1 to 50% by weight of the shell component, said structuring agent present in the form of platelets, wherein said polymer material comprises pendant ionic groups comprising polyanions or polycations and said polymer is selected from the group consisting of gelatin, alginate, carrageenan, casein, proteins, polysaccharides, gums, synthetic polymer materials, celluloses, waxes, rosins, polyphosphates, and mixtures thereof wherein said polymer forms an ionic bridge with said dispersed structuring agent, wherein said structuring agent decreases oxygen and water permeability and protects the encapsulated ingredient from oxygen and water permeability through said polymer material rendering said shell component substantially oxygen and water impermeable and wherein said structuring agent is selected from the group consisting of clay, silicates and silicas, phospholipids, pillared-like materials, metal salts, nanoplatelets, and mixtures thereof; and wherein said polymer material forms an interior shell around said core component, and said structuring agent forms an exterior shell around said interior shell such that a gradient exists extending radially into said microcapsule from a distinct outer layer containing only said structuring agent to a mixture of said structuring agent and a polymer material to only said polymer material. 2. The microencapsulated material of claim 1, wherein said core component is selected from the group consisting of unsaturated fatty acids, betacarotene, lutein, zeazanthin, iron salts, copper salts, selenium salts, flavonoids, coenzyme Q10, herbs, spices, flavorants, extracts, protein and peptide drugs, amino acids and amino acid residues, surfactants, enzymes, peroxides, fragrances, catalysts, vitamins, nutritional supplements, minerals, herbal products, food additives, and mixtures thereof. 3. The microencapsulated material of claim 1, said shell component further comprising at least one additive selected from the group consisting of antioxidants, amino acid residues, phospholipids, sugars, and cross-linking agents. 4. The microencapsulated material of claim 1, further comprising at least one additive selected from the group consisting of antioxidants, amino acid residues, phospholipids, and sugars, wherein said at least one additive further decreases oxygen or water permeability through said polymer material. 5. The microencapsulated material of claim 1, wherein said microencapsulated material is in a form of a powder. 6. The microencapsulated material of claim 1, wherein said microencapsulated material is in a form of a membrane wherein said core component is dispersed and encapsulated within a continuous matrix of said shell component. 7. A microencapsulated material, comprising: a core component, wherein said core component is at least one of oxygen sensitive or water sensitive; a shell component encapsulating said core component, said shell component comprising an interior shell, an exterior shell, and choline or pyridine to provide charge neutrality; a gradient extending radially into said shell component from a distinct outer layer containing only structuring agent to a mixture of said structuring agent and a polymer material to only said polymer material; wherein said polymer material forms said interior shell around said core component, and said structuring agent forms said exterior shell around said interior shell; wherein said structuring agent decreases oxygen and water permeability and protects the core component from oxygen and water permeability through said polymer material rendering said shell component substantially oxygen and water impermeable, said structuring agent in the form of platelets having an average particle size from about 0.1 to about 1 μm at a level of about 1 to 50% by weight of said shell component and selected from the group consisting of clay, silicates and silicas, phospholipids, pillared-like materials, metal salts, nanoplatelets, and mixtures thereof; and wherein said polymer material comprises pendant ionic groups comprising polyanions or polycations and said polymer is selected from the group consisting of gelatin, alginate, carrageenan, casein, proteins, polysaccharides, gums, synthetic polymer materials, celluloses, waxes, rosins, polyphosphates, and mixtures thereof wherein said polymer forms an ionic bridge with said structuring agent. 8. The microencapsulated material of claim 1, wherein said microencapsulated material is formed by a method selected from atomization methods, coacervation methods, and extrusion methods.
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