IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
UP-0837260
(2004-04-30)
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등록번호 |
US-7799336
(2010-10-11)
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발명자
/ 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
37 인용 특허 :
119 |
초록
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Biocompatible intraocular implants include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide component into an eye for an extended period of time. The prostamide component may be associated with a biodegradable polymer matrix, such as a ma
Biocompatible intraocular implants include a prostamide component and a biodegradable polymer that is effective in facilitating release of the prostamide component into an eye for an extended period of time. The prostamide component may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat or reduce a at least one symptom of an ocular condition, such as glaucoma.
대표청구항
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I claim: 1. A biodegradable intraocular implant comprising: a prostamide component and a biodegradable polymer matrix that releases drug at a rate effective to sustain release of a therapeutically effective amount of the prostamide component for at least about one week after the implant is placed i
I claim: 1. A biodegradable intraocular implant comprising: a prostamide component and a biodegradable polymer matrix that releases drug at a rate effective to sustain release of a therapeutically effective amount of the prostamide component for at least about one week after the implant is placed in an eye. 2. The implant of claim 1, wherein the prostamide component comprises a single type of a prostamide derivative. 3. The implant of claim 1, wherein the prostamide component is dispersed within the biodegradable polymer matrix. 4. The implant of claim 1, wherein the prostamide component comprises bimatoprost provided in an amount of about 0.1% to about 90% by weight of the implant. 5. The implant of claim 1, wherein the prostamide component comprises a compound having the formula (I) wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A is an alkylene or alkenylene radical having from two to six carbon atoms, which radical may be interrupted by one or more oxide radicals and substituted with one or more hydroxy, oxo, alkyloxy or alkylcarboxy groups wherein said alkyl radical comprises from one to six carbon atoms; B is a cycloalkyl radical having from three to seven carbon atoms, or an aryl radical, selected from the group consisting of hydrocarbyl aryl and heteroaryl radicals having from four to ten carbon atoms wherein the heteroatom is selected from the group consisting of nitrogen, oxygen and sulfur atoms; X is a radical selected from the group consisting of —OR4 and —N(R4)2 wherein R4 is selected from the group consisting of hydrogen, a lower alkyl radical having from one to six carbon atoms, wherein R5 is a lower alkyl radical having from one to six carbon atoms; Z is ═O or represents 2 hydrogen radicals; one of R1 and R2 is ═O, —OH or a —O(CO)R6 group, and the other one is —OH or —O(CO)R6, or R1 is ═O and R2 is H, wherein R6 is a saturated or unsaturated acyclic hydrocarbon group having from 1 to about 20 carbon atoms, or —(CH2)mR7 wherein m is 0 or an integer of from 1 to 10, and R7 is cycloalkyl radical, having from three to seven carbon atoms, or a hydrocarbyl aryl or heteroaryl radical, as defined above, or a pharmaceutically-acceptable salt thereof, provided, however, that when B is not substituted with a pendant heteroatom-containing radical, and Z is ═O, then X is not —OR4. 6. The implant of claim 1, wherein the matrix comprises a mixture of two different biodegradable polymers, each polymer selected from the group consisting of polylactic acid, polyglycolic acid, polylactide-co-glycolide, derivatives thereof, and mixtures thereof. 7. The implant of claim 6, wherein the matrix comprises a mixture of two different polylactic acids. 8. The implant of claim 6, wherein the matrix comprises a mixture of a polylactic acid and a polylactide-co-glycolide. 9. The implant of claim 1, wherein the matrix comprises a mixture of different biodegradable polymers, each biodegradable polymer having a different inherent viscosity. 10. The implant of claim 1, wherein the matrix comprises a mixture of different biodegradable polymers, each polymer having a different molecular weight. 11. The implant of claim 1, wherein the matrix releases drug at a rate effective to sustain release of an amount of the prostamide component from the implant for more than one month from the time the implant is placed in the vitreous of the eye. 12. The implant of claim 1, wherein the therapeutically effective amount of the prostamide component is an amount effective to stimulate aqueous humor outflow in the eye in which the implant is placed. 13. The implant of claim 1, further comprising a prostaglandin analogue. 14. The implant of claim 13 wherein the prostaglandin analog is unoprostone. 15. The implant of claim 1, further comprising an intraocular pressure lowering drug other than a prostamide derivative. 16. The implant of claim 1, wherein the implant is structured to be placed in the vitreous of the eye. 17. The implant of claim 1 which is formed by an extrusion process.
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