IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0510267
(2003-04-04)
|
등록번호 |
US-7803129
(2010-10-21)
|
우선권정보 |
CA-2380671(2002-04-05) |
국제출원번호 |
PCT/CA2003/000516
(2003-04-04)
|
§371/§102 date |
20050314
(20050314)
|
국제공개번호 |
WO03/086510
(2003-10-23)
|
발명자
/ 주소 |
- Brouillette, Martin
- Dufresne, Stephane
|
출원인 / 주소 |
- Societe de Commercialisation des Produits de la Recherche Appliquee-Socpra Sciences et Genie, S.E.C.
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
8 |
초록
▼
Described are a method and device for needleless injection of a liquid substance in the skin or other target tissue of a patient, in which droplets of the liquid substance are produced, and the droplets of liquid substance are directed toward the surface of the patient's skin or other target tissue
Described are a method and device for needleless injection of a liquid substance in the skin or other target tissue of a patient, in which droplets of the liquid substance are produced, and the droplets of liquid substance are directed toward the surface of the patient's skin or other target tissue at a velocity sufficiently high to inject the droplets of liquid substance in the patient's skin or other target tissue. The droplets of the liquid substance are accelerated toward the surface of the patient's skin or other target tissue in order to inject the accelerated droplets of liquid substance in the patient's skin or other target tissue. A high velocity jet of gas is produced, droplets of the liquid substance are produced and supplied in the high velocity jet of gas, the droplets of liquid substance are conveyed within the high velocity jet of gas, and the high velocity jet of gas is guided toward the surface of the patient's skin or other target tissue in order to inject the conveyed droplets of liquid substance in the patient's skin or other target tissue.
대표청구항
▼
What is claimed is: 1. A method for needleless injection of a liquid substance into a target biological tissue, comprising: generating a high velocity jet of gas; generating droplets of the liquid substance; supplying and conveying the droplets of the liquid substance into the high velocity jet of
What is claimed is: 1. A method for needleless injection of a liquid substance into a target biological tissue, comprising: generating a high velocity jet of gas; generating droplets of the liquid substance; supplying and conveying the droplets of the liquid substance into the high velocity jet of gas; and guiding the high velocity jet of gas through a channel toward a surface of the target biological tissue for injecting the conveyed droplets of the liquid substance into the target biological tissue; wherein generating the droplets of the liquid substance comprises: containing the liquid substance into a reservoir; interposing a perforated membrane between the reservoir and the channel in such a manner that the flow of the high velocity jet of gas is guided along a face of the perforated membrane on a side of the perforated membrane opposite to the reservoir of the liquid substance; and pressurizing the reservoir containing the liquid substance to force the liquid substance from the liquid reservoir through the perforated membrane to thereby produce a jet of the liquid substance that transforms into a stream of the droplets supplied within the high velocity jet of gas laterally of the direction of the flow said high velocity jet of gas. 2. A method for needleless injection of a liquid substance as defined in claim 1, wherein generating the high velocity jet of gas comprises: supplying pressurized gas from a gas reservoir to a convergent-divergent. 3. A method for needleless injection of a liquid substance as defined in claim 1, wherein generating the high velocity jet of gas comprises: supplying pressurized gas from a gas reservoir to a convergent. 4. A method for needleless injection of a liquid substance as defined in claim 1, wherein generating the high velocity jet of gas comprises generating a jet of inert gas. 5. A method for needleless injection of a liquid substance as defined in claim 1, wherein generating the droplets of the liquid substance comprises forcing the liquid substance from the liquid reservoir through at least one micro-orifice of the perforated membrane. 6. A method for needleless injection of a liquid substance as defined in claim 1, wherein pressurizing the reservoir containing the liquid substance comprises: supplying pressurized gas from a gas reservoir to the reservoir containing the liquid substance. 7. A method for needleless injection of a liquid substance as defined in claim 1, comprising generating the high velocity jet of gas prior to generating the droplets of the liquid substance to thereby supply the droplets of the liquid substance in a steady-state high velocity jet of gas. 8. A needleless syringe for injecting a liquid substance into a target biological tissue, comprising: a generator of high velocity jet of gas; a generator of droplets of the liquid substance having an outlet for supplying the droplets of the liquid substance into the high velocity jet of gas whereby the droplets of the liquid substance are conveyed within the high velocity jet of gas; and a channel for guiding the high velocity jet of gas toward a surface of the target biological tissue to thereby inject the conveyed droplets of the liquid substance into the target biological tissue; wherein the generator of the droplets of the liquid substance comprises: a reservoir containing the liquid substance; a perforated membrane interposed between the reservoir of the liquid substance and the channel for guiding the high velocity jet of gas; and a source of pressurization of the reservoir containing the liquid substance to force the liquid substance from the liquid reservoir through the perforated membrane to thereby produce a jet of the liquid substance that transforms into a stream of the droplets; and wherein the perforated membrane is interposed between the liquid reservoir and the channel for guiding the flow of the high velocity jet of gas along a face of the perforated membrane on a side of the perforated membrane opposite to the liquid reservoir, whereby the jet of the liquid substance and the generated droplets of the liquid substance are supplied within the high velocity jet of gas laterally of the direction of the flow of said high velocity jet of gas. 9. A needleless syringe for injecting a liquid substance as defined in claim 8, wherein the generator of high velocity jet of gas comprises: a convergent-divergent having an inlet; and a pressurized gas supply connected to the inlet of the convergent-divergent to supply pressurized gas to the convergent-divergent and thereby generate the high velocity jet of gas. 10. A needleless syringe for injecting a liquid substance as defined in claim 9, wherein the pressurized gas supply comprises: a reservoir of pressurized gas; and a valve interposed between the reservoir of pressurized gas and the inlet of the convergent-divergent to controllably supply pressurized gas from the reservoir of pressurized gas to the inlet of the convergent-divergent and thereby generate the high velocity jet of gas. 11. A needleless syringe for injecting a liquid substance as defined in claim 8, wherein the generator of high velocity jet of gas comprises: a convergent having an inlet; and a pressurized gas supply connected to the inlet of the convergent to supply pressurized gas to the convergent and thereby generate the high velocity jet of gas. 12. A needleless syringe for injecting a liquid substance as defined in claim 11, wherein the pressurized gas supply comprises: a reservoir of pressurized gas; and a valve interposed between the reservoir of pressurized gas and the inlet of the convergent to controllably supply pressurized gas from the reservoir to the inlet of the convergent and thereby generate the high velocity jet of gas. 13. A needleless syringe for injecting a liquid substance as defined in claim 8, wherein the high velocity jet of gas comprises inert gas. 14. A needleless syringe for injecting a liquid substance as defined in claim 8, wherein the perforated membrane comprises at least one micro-orifice and the source of pressurization comprises a pressurized gas supply connected to the reservoir of the liquid substance to supply pressurized gas to the reservoir and force the liquid substance through the perforated membrane to thereby generate the droplets of the liquid substance supplied in the channel and, therefore, in the high velocity jet of gas. 15. A needleless syringe for injecting a liquid substance as defined in claim 14, wherein the pressurized gas supply comprises: a reservoir of pressurized gas; and a valve interposed between the reservoir of pressurized gas and the reservoir of the liquid substance to controllably supply pressurized gas from the reservoir of pressurized gas to the reservoir of the liquid substance to thereby force the liquid substance through the perforated membrane and thereby generate the droplets of the liquid substance supplied in the channel and, therefore, in the high velocity jet of gas. 16. A needleless syringe for injecting a liquid substance as defined in claim 14, wherein the perforated membrane comprises a metallic or polymeric membrane provided with the at least one micro-orifice. 17. A needleless syringe for injecting a liquid substance as defined in claim 14, wherein the generator of the high velocity jet of gas comprises: a convergent-divergent comprising a throat through which the high velocity jet of gas travels; wherein: the perforated membrane is interposed between the reservoir of the liquid substance and the throat of the convergent-divergent. 18. A needleless syringe for injecting a liquid substance as defined in claim 8, wherein the generator of the high velocity jet of gas comprises: a pressurized gas supply; a convergent-divergent having an inlet; and an intermediate chamber interposed between the pressurized gas supply of the generator of the high velocity jet of gas and the inlet of the convergent-divergent. 19. A needleless syringe for injecting a liquid substance as defined in claim 18, wherein the generator of the high velocity jet of gas further comprises: a first valve interposed between the pressurized gas supply of the generator of the jet of gas and the intermediate chamber to control supply of pressurized gas from said pressurized gas supply to the intermediate chamber; and a second valve interposed between the intermediate chamber and the inlet of the convergent-divergent to control supply of pressurized gas from the intermediate chamber to the convergent-divergent. 20. A needleless syringe for injecting a liquid substance as defined in claim 8, wherein the generator of the high velocity jet of gas comprises: a pressurized gas supply; a convergent having an inlet; and an intermediate chamber interposed between the pressurized gas supply of the generator of the high velocity jet of gas and the inlet of the convergent. 21. A needleless syringe for injecting a liquid substance as defined in claim 20, wherein the generator of the high velocity jet of gas comprises: a first valve interposed between the pressurized gas supply of the generator of the high velocity jet of gas and the intermediate chamber to control supply of pressurized gas from said pressurized gas supply to the intermediate chamber; and a second valve interposed between the intermediate chamber and the inlet of the convergent to control supply of pressurized gas from the intermediate chamber to the convergent. 22. A needleless syringe for injecting a liquid substance as defined in claim 14, wherein the generator of the droplets of the liquid substance further comprises: an intermediate chamber interposed between the pressurized gas supply and the reservoir of the liquid substance. 23. A needleless syringe for injecting a liquid substance as defined in claim 22, wherein the generator of the droplets of the liquid substance further comprises: a first valve interposed between the pressurized gas supply and the intermediate chamber to control supply of pressurized gas from the pressurized gas supply to the intermediate chamber; and a second valve interposed between the intermediate chamber and the reservoir of liquid substance to control supply of pressurized gas from the intermediate chamber to the reservoir of the liquid substance. 24. A needleless syringe for injecting a liquid substance as defined in claim 23, wherein the reservoir of the liquid substance comprises: a liquid chamber adjacent to the perforated membrane for containing the liquid substance; a gas-tight chamber; and a slidable piston interposed between the liquid chamber and the gas-tight chamber; wherein: the second valve is interposed between the intermediate chamber and the gas-tight chamber to control supply of pressurized gas from the intermediate chamber to the gas-tight chamber; and the supply of pressurized gas to the gas-tight chamber applies a pressure on the slidable piston to compress the liquid substance in the liquid chamber and force the liquid substance through the perforated membrane to thereby generate the droplets of the liquid substance supplied in the high velocity jet of gas. 25. A needleless syringe for injecting a liquid substance as defined in claim 10, wherein the valve is an electronic valve. 26. A needleless syringe for injecting a liquid substance as defined in claim 10, wherein the valve is a mechanical valve comprising elements selected from the group consisting of pistons, springs and plungers. 27. A method for needleless injection of a liquid substance into a target biological tissue, the method comprising: generating droplets of the liquid substance; accelerating the droplets of the liquid substance at a velocity sufficiently high to inject the droplets of the liquid substance into the target biological tissue; and directing the droplets of the liquid substance toward a surface of the target biological tissue at the sufficiently high velocity to inject the droplets of the liquid substance into the target biological tissue; wherein generating the droplets of the liquid substance comprises injecting a pressurized gas from a pressurized source into a reservoir containing the liquid substance to force the liquid substance from the liquid reservoir through at least one micro-orifice of a perforated membrane to thereby produce a jet of the liquid substance, wherein the jet of the liquid substance transforms into a stream of the droplets. 28. A needleless syringe for injecting a liquid substance into a target biological tissue, comprising: a generator of droplets of the liquid substance; and a droplet accelerator for accelerating the droplets of the liquid substance toward a surface of the target biological tissue in order to inject the accelerated droplets into the target biological tissue; and wherein the generator of droplets comprises: a reservoir of the liquid substance to be injected; a perforated membrane comprising at least one micro-orifice through which the liquid substance from the reservoir is supplied; a source of pressurized gas; and a valve for connecting the source of pressurized gas to the reservoir of the liquid substance, wherein opening of the valve causes pressurized gas from the source to be supplied to the reservoir for pressurizing the reservoir of the liquid substance and forcing the liquid substance through the at least one micro-orifice of the perforated membrane to thereby produce a jet of the liquid substance, wherein the jet of the liquid substance transforms into a stream of the droplets. 29. A method for needleless injection of a liquid substance into a target biological tissue, the method comprising: generating droplets of the liquid substance; accelerating the droplets of the liquid substance, at a velocity sufficiently high to inject the droplets of the liquid substance into the target biological tissue; and directing the droplets of the liquid substance toward a surface of the target biological tissue at the sufficiently high velocity to inject the droplets of the liquid substance into the target biological tissue; wherein generating the droplets of the liquid substance comprises: supplying pressurized gas to a gas-tight chamber; applying, by means of the pressurized gas in the gas-tight chamber, a pressure to a slidable piston interposed between the gas-tight chamber and a reservoir of the liquid substance to be injected; compressing the liquid substance in the liquid reservoir by means of the pressure applied to the slidable piston to force the liquid substance through at least one micro-orifice of a perforated membrane to thereby produce a jet of the liquid substance, wherein the jet of the liquid substance transforms into a stream of the droplets. 30. A needleless syringe for injecting a liquid substance into a target biological tissue, comprising: a generator of droplets of the liquid substance; and a droplet accelerator for accelerating the droplets of the liquid substance toward a surface of the target biological tissue in order to inject the accelerated droplets into the target biological tissue; and wherein the generator of droplets comprises: a source of pressurized gas; a gas-tight chamber connected to the source of pressurized gas through a valve; a reservoir of the liquid substance to be injected; a slidable piston interposed between the liquid reservoir and the gas-tight chamber; a perforated membrane comprising at least one micro-orifice through which the liquid substance from the reservoir is supplied; and wherein opening of the valve to supply pressurized gas from the source to the gas-tight chamber applies a pressure on the slidable piston to compress the liquid substance in the liquid reservoir and force the liquid substance through the at least one micro-orifice of the perforated membrane to thereby produce a jet of the liquid substance, wherein the jet of the liquid substance transforms into a stream of the droplets. 31. A method for needleless injection of a liquid substance into a target biological tissue, the method comprising: generating a high velocity jet of gas; generating droplets of the liquid substance; supplying and conveying the droplets of the liquid substance into the high velocity jet of gas; and guiding the high velocity jet of gas through a channel toward a surface of the target biological tissue for injecting the conveyed droplets of the liquid substance into the target biological tissue; wherein generating the droplets of the liquid substance comprises containing the liquid substance in a cylindrical reservoir positioned coaxial within the channel, the cylindrical reservoir comprising a downstream perforated membrane and an upstream slidable piston and the liquid substance being contained in the cylindrical reservoir between the perforated membrane and the slidable piston; wherein generating the high velocity jet of gas comprises releasing upstream of the channel pressurized gas to produce the high velocity jet of gas; and wherein pressurized gas released in the channel applies a pressure to the slidable piston to compress the liquid substance in the liquid reservoir and force the liquid substance through the perforated membrane to thereby produce a jet of the liquid substance, the jet of the liquid substance transforming into a stream of the droplets supplied in the high velocity jet of gas. 32. A needleless syringe for injecting a liquid substance into a target biological tissue, the syringe comprising: a generator of high velocity jet of gas; a generator of droplets of the liquid substance having an outlet for supplying the droplets of the liquid substance into the high velocity jet of gas whereby the droplets of the liquid substance are conveyed within the high velocity jet of gas; and a channel for guiding the high velocity jet of gas toward a surface of the target biological tissue to thereby inject the conveyed droplets of the liquid substance into the target biological tissue; wherein the generator of the droplets of the liquid substance comprises a cylindrical reservoir containing the liquid substance and positioned coaxial within the channel, the cylindrical reservoir comprising a downstream perforated membrane and an upstream slidable piston and the liquid substance being contained in the cylindrical reservoir between the perforated membrane and the slidable piston; wherein the generator of the high velocity jet of gas comprises a source of pressurized gas positioned upstream of the channel to release in the channel pressurized gas to produce the high velocity jet of gas; and wherein pressurized gas released form the source applies a pressure to the slidable piston to compress the liquid substance in the liquid reservoir and force the liquid substance through the perforated membrane to thereby produce a jet of the liquid substance, the jet of the liquid substance transforming into a stream of the droplets supplied in the high velocity jet of gas.
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