Chip based diagnostic device
원문보기
IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0168122
(2005-06-28)
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등록번호 |
US-7820103
(2010-11-15)
|
우선권정보 |
EP-04015573(2004-07-02) |
발명자
/ 주소 |
- Belz, Renato
- Carsten, Haack
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출원인 / 주소 |
- Roche Molecular Systems, Inc.
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
3 |
초록
▼
A diagnostic device comprising a sample inlet and a processing chamber having a window portion and a flat carrier having front surface, a back surface and one or more side surfaces, said front surface facing said processing chamber, said front surface having an active surface containing a diagnostic
A diagnostic device comprising a sample inlet and a processing chamber having a window portion and a flat carrier having front surface, a back surface and one or more side surfaces, said front surface facing said processing chamber, said front surface having an active surface containing a diagnostic reagent immobilized to said active front surface and an extended front surface, wherein said window portion further contains a rim portion facing said extended front surface sealing said chamber versus said carrier through said extended front surface.
대표청구항
▼
The invention claimed is: 1. A diagnostic device comprising a sample inlet and a processing chamber having a tubular body, a window portion and a flat carrier having front surface facing said processing chamber, said front surface having an active surface containing a diagnostic reagent immobilized
The invention claimed is: 1. A diagnostic device comprising a sample inlet and a processing chamber having a tubular body, a window portion and a flat carrier having front surface facing said processing chamber, said front surface having an active surface containing a diagnostic reagent immobilized to said active front surface and an extended front surface, wherein said window portion further contains a rim portion facing said extended front surface sealing said chamber versus said carrier through said extended front surface, further comprising a locking frame to push the carrier towards said rim portion up to a dead stop position, said locking frame having a substantially flat structure comprising clips spanning corners of said frame, said clips being more flexible than the frame, wherein each clip is a brace bridging a corner by connecting two adjacent sides of the frame, and wherein there is a gap between each clip and the corner it spans. 2. The device according to claim 1, wherein said rim portion contains a circumferential wall made of an elastic material. 3. The device according to claim 1, wherein said locking frame is flat containing metal parts. 4. The device according to claim 1, wherein the sample inlet is closed by a cap comprising a pierceable membrane. 5. The device according to claim 1, wherein the processing chamber is a mixing chamber. 6. A method for assembling a diagnostic device according to claim 1, comprising : providing a device comprising a processing chamber having an open window portion, said window portion further containing a rim portion, positioning said device, providing said flat carrier, placing the front surface of said carrier on to said rim portion such that said front surface faces said processing chamber and said rim seals said chamber versus said carrier through said extended front surface, providing a locking frame having clips spanning corners of said frame, wherein each clip is a brace bridging a corner by connecting two adjacent sides of the frame, and wherein there is a gap between each clip and the corner it spans and pressing said locking frame towards the device such that it is retained in a position that fixes the carrier. 7. The method of claim 6 further comprising labeling the device. 8. A method for determining the presence of an analyte in a sample in an instrument comprising the steps: providing a device according to claim 1, positioning said device within said instrument, placing said sample into said device such that said sample is in contact with the active surface of said carrier, reacting said analyte with said diagnostic reagent, and determining the results of said reaction as a measure of the presence of said analyte in said sample. 9. The method of claim 8, further comprising the step of removing liquid from said processing chamber. 10. The method of claim 8, further comprising a step of dispensing and aspirating a washing liquid to said processing chamber. 11. The method of claim 8, further comprising mixing any liquid in said processing chamber. 12. The method of claim 11, wherein said mixing is done by vortex shaking. 13. A diagnostic instrument for determining the presence of an analyte in a sample comprising: one or more devices according to claim 1, a module for entering a sample into said device, and a module for determining the results of the reaction of analytes in said sample with said reagents.
이 특허에 인용된 특허 (3)
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Gallagher Gerald B. (9 Main St. Acton MA 01720), Display apparatus for desired items with easy exchange of desired items, and with protection from ultra-violet light.
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Atwood John G. (West Redding CT) Haff Lawrence A. (Wilton CT), In situ PCR amplification system.
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Borod Murray (3723 Parker Hill Rd. Santa Rosa CA 95404), Picture frame corner connector.
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