[특허]Methods of using CRCA-1 as a stomach and esophageal cancer marker

Methods of using CRCA-1 as a stomach and esophageal cancer marker 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12Q-001/68 C12P-019/34 C07H-021/02 C07H-021/04
출원번호	UP-0380718 (2001-09-18)
등록번호	US-7829276 (2010-11-25)
국제출원번호	PCT/US2001/029091 (2001-09-18)
§371/§102 date	20031215 (20031215)
국제공개번호	WO02/022885 (2002-03-21)
발명자 / 주소	Waldman, Scott A. Pearlman, Joshua M. Barber, Michael T. Schulz, Stephanie Parkinson, Scott J. Prawer, Scott
출원인 / 주소	Thomas Jefferson University
대리인 / 주소	Pepper Hamilton LLP
인용정보	피인용 횟수 : 0 인용 특허 : 41

초록 ▼

Screening and diagnostic reagents, kits and methods for stomach or esophageal cancer are disclosed. Compounds, compositions and methods of treating patients with stomach or esophageal cancer and for imaging stomach or esophageal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as drugs, gene therapeutics and antisense compounds to stomach or esophageal cells are disclosed. Vaccines compositions and methods of for treating and preventing stomach or esophageal cancer are disclosed.

대표청구항 ▼

The invention claimed is: 1. An in vitro method of screening a human individual for stomach or esophageal adenocarcinoma cells comprising the steps of: a) examining a sample of extraintestinal tissue and/or body fluids from a human individual to determine whether CRCA-1 transcript is present above background levels in cells in said sample wherein the presence of said CRCA-1 transcript above background levels indicates the possible presence of stomach or esophageal adenocarcinoma cells in said sample; and wherein CRCA-1 transcript has the nucleotide sequence of SEQ ID NO:1, and b) identifying said human individual as possibly having stomach or esophageal adenocarcinoma if the CRCA-1 transcript is present above background levels in cells in the sample from the human individual. 2. The method of claim 1 wherein the presence of said CRCA-1 transcript above background levels is determined by polymerase chain reaction wherein said sample is contacted with primers that selectively amplify said CRCA-1 transcript or cDNA generated therefrom. 3. The method of claim 1 wherein said sample is body fluid. 4. The method of claim 1 wherein said sample is blood. 5. The method of claim 1 wherein said sample is lymph node tissue. 6. An in vitro method of screening a human individual for stomach or esophageal adenocarcinoma comprising the steps of: a) examining a sample of extraintestinal tissue and/or body fluids from a human individual to determine whether a CRCA-1 transcript is present above background levels in said sample, wherein the presence of a CRCA-1 transcript above background levels in said sample suggests that said human individual may have stomach or esophageal adenocarcinoma; and wherein CRCA-1 transcript has the nucleotide sequence of SEQ ID NO:1; and b) identifying said human individual as possibly having stomach or esophageal adenocarcinoma if the CRCA-1 transcript is present above background levels in cells in the sample from the human individual. 7. The method of claim 6 wherein said sample is body fluid. 8. The method of claim 6 wherein said sample is blood. 9. The method of claim 6 wherein said sample is lymph node tissue. 10. The method of claim 6 wherein said CRCA-1 transcript is detected above background levels by polymerase chain reaction assay using primers which specifically amplify CRCA-1 transcript sequences. 11. A method of diagnosing a human individual who has stomach or esophageal adenocarcinoma comprising the steps of: identifying a human individual who is suspected of having stomach or esophageal adenocarcinoma; and examining a sample of extraintestinal tissue and/or body fluids from said human individual who is suspected of having stomach or esophageal adenocarcinoma to detect the presence of CRCA-1 transcript above background levels wherein the presence of CRCA-1 transcript above background levels in a sample of extraintestinal tissue and/or body fluids from a human individual who is suspected of having stomach or esophageal adenocarcinoma indicates that the human individual has stomach or esophageal cancer; and wherein CRCA-1 transcript has the nucleotide sequence of SEQ ID NO: 1. 12. The method of claim 11 wherein the presence of CRCA-1 transcript above background levels is detected by polymerase chain reaction wherein said sample is contacted with primers that selectively amplify said CRCA-1 transcript or cDNA generated therefrom. 13. The method of claim 11 wherein said sample is body fluid. 14. The method of claim 11 wherein said sample is blood. 15. The method of claim 11 wherein the human individual is suspected of having stomach adenocarcinoma. 16. The method of claim 15 wherein the human individual has been treated for stomach adenocarcinoma. 17. The method of claim 11 wherein the human individual is suspected of having esophageal adenocarcinoma. 18. The method of claim 17 wherein the human individual has been treated for esophageal adenocarcinoma. 19. A method of detecting evidence of CRCA-1 expression in a sample of esophageal or stomach tissue from a human individual suspected of being at high risk for stomach or esophageal adenocarcinoma, the method comprising the steps of: a) identifying a human individual as being at a high risk for stomach or esophageal adenocarcinoma; and b) examining a sample of esophageal or stomach tissue from the human individual to detect the presence of CRCA-1 transcript above background levels in the sample; wherein CRCA-1 transcript has the nucleotide sequence of SEQ ID NO:1. 20. The method of claim 19 wherein the presence of CRCA-1 transcript is detected by polymerase chain reaction wherein said sample is contacted with primers that selectively amplify said CRCA-1 transcript or cDNA generated therefrom. 21. The method of claim 19 wherein the method comprises the step of examining a sample of esophageal tissue from a human individual to detect the presence of CRCA-1 transcript in the sample. 22. The method of claim 19 wherein the human individual has been previously diagnosed as having esophageal adenocarcinoma. 23. The method of claim 19 wherein the method comprises the step of examining a sample of stomach tissue from a human individual to detect the presence of CRCA-1 transcript in the sample. 24. The method of claim 19 wherein the human individual has been previously diagnosed as having stomach adenocarcinoma.

이 특허에 인용된 특허 (41)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Methods of using CRCA-1 as a stomach and esophageal cancer marker 원문보기

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Methods of using CRCA-1 as a stomach and esophageal cancer marker 원문보기

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연구과제 타임라인

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