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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | UP-0946632 (2007-11-28) |
| 등록번호 | US-7833266 (2011-01-16) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 0 인용 특허 : 302 |
The invention is directed to a stent that delivers multiple therapeutic regimens from different regions of the stent.
The invention claimed is: 1. A stent, the stent having a body comprising a plurality of members, the plurality of members including struts and connectors, the body comprising: a first region, the first region comprising a first plurality of struts arranged in a plurality of circumferential bands, l
The invention claimed is: 1. A stent, the stent having a body comprising a plurality of members, the plurality of members including struts and connectors, the body comprising: a first region, the first region comprising a first plurality of struts arranged in a plurality of circumferential bands, longitudinally adjacent bands being engaged by connectors, each strut defining a first plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a first density, each coating retainer having a depth, width, and length and having a first volume, each first coating retainer having a first volume of a first therapeutic agent, the first volume of first therapeutic agent equal to the first volume of the coating retainers, the first plurality of coating retainers eluting a first total volume of a first therapeutic agent; and a second region longitudinally adjacent to the first region, the second region comprising a second plurality of struts arranged in a plurality of circumferential bands, longitudinally adjacent bands being engaged by connectors, each strut defining a second plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a second density, each coating retainer having a depth, width, and length and having a second volume, each coating retainer having a second volume of a second therapeutic agent, the second volume of second therapeutic agent equal to the second volume of the second coating retainers, the plurality of second coating retainers eluting a second total volume of a second therapeutic agent; and a side branch, the side branch in an expanded state extending at an angle to the body of the stent, the side branch comprising a third plurality of struts, each strut defining a plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a third density, each coating retainer having a depth, width, and length; wherein the first density is greater than the second density and the second density is greater than the third density, the first total volume of therapeutic agent is greater than the second total volume of therapeutic agent, and the first volume of each of the first plurality of coating retainers is greater than the second volume each of the second plurality of coating retainers. 2. The stent of claim 1, each of the plurality of members having a width and a length, the width being substantially constant along the length of the member. 3. The stent of claim 1, each of the plurality of members having a thickness and a length, the thickness being substantially constant along the length of the member. 4. The stent of claim 1, the first plurality of coating retainers greater than the second plurality of coating retainers. 5. The stent of claim 1, the first therapeutic agent being different than the second therapeutic agent. 6. The stent of claim 1, the first volume being determined by a first length, a first width and a first depth and the second volume being determined by a second length, a second width and a second depth, wherein at least one of the first length, the first width and the first depth is different from at least one of the second length, the second width and the second depth. 7. A bifurcated stent, the bifurcated stent having a tubular body comprising a plurality of members, the plurality of members comprising a plurality of struts and connectors, the tubular body comprising: a first region, the first region having a first plurality of struts, the plurality of struts connected one to another by turns and arranged in circumferential bands adjacent circumferential bands engaged by connectors, each strut defining a first plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a first density and eluting a first local concentration of therapeutic agent, the each coating retainer having a first size; and a second region longitudinally adjacent to the first region, the second region having a second plurality of struts and a side branch, the second plurality of struts connected one to another by turns and arranged in circumferential bands, adjacent circumferential bands engaged by connectors, each strut defining a second plurality of coating retainers, all of the coating retainers defined by a strut being arranged in a second density and eluting a second local concentration of therapeutic agent, each coating retainer having a second size, the side branch comprising a plurality of struts, the plurality of struts extending at an angle to the tubular body of the bifurcated stent when the side branch is in an expanded state; wherein the first density is greater than the second density, the first local concentration is greater than the second local concentration, and the first size is equal to the second size. 8. A bifurcated stent having a tubular body comprising a first section, a second section, and a third section, the first section forming a first end region of the bifurcated stent and the third section forming a second end region of the bifurcated stent, the first section comprising a plurality of struts engaged one to another by turns, each strut defining a first number of coating retainers, all of the coating retainers defined by a strut have a first density, the plurality of struts arranged in circumferential bands, adjacent circumferential bands being engaged one to another by connectors; the second section comprising a plurality of struts engaged one to another by turns, each strut defining a second number of coating retainers, all of the coating retainers defined by a strut have a second density, the second section further comprising a side branch, the side branch extending at an angle to the tubular body of the bifurcated stent when the side branch is in an expanded state, the side branch comprising a plurality of struts, each strut defining a third number of coating retainers, all of the coating retainers defined by a strut have a third density; the third section comprising a plurality of struts engaged one to another by turns, each strut defining a fourth number of coating retainers, all of the coating retainers defined by a strut have a fourth density, the plurality of struts arranged in circumferential bands, adjacent circumferential bands being engaged one to another by connectors; wherein the first number of coating retainers and the fourth number of coating retainers are the same, wherein the first density and the fourth density are the same, and wherein the third number of coating retainers is different than the first number of coating retainers. 9. The stent of claim 8, wherein the second density is the same as the first and fourth densities. 10. The stent of claim 9, wherein each strut has a length, the struts of third section having a shorter length than the struts of the first, second, and fourth sections. 11. The stent of claim 8, wherein the second number of coating retainers is the same as the first number of coating retainers. 12. The stent of claim 8, wherein the second density is two times greater than the first density and two times greater than the fourth density. 13. The stent of claim 8, wherein the second density is less than the first and fourth densities and greater than the third density. 14. The stent of claim 8, wherein the second number of coating retainers is different than the first number of coating retainers. 15. The stent of claim 8, the second section further comprising a perimeter member, at least some of the plurality of struts of the side branch being engaged to the perimeter member and some of the plurality of struts of the second region being engaged to the perimeter member, the perimeter member defining a fifth number of coating retainers, the fifth number being greater than the first, second, third, and fourth numbers of coating retainers. 16. The stent of claim 15, the perimeter member being engaged to a circumferential band of the first section by a connector and being engaged to a circumferential band of the second section by a connector. 17. The stent of claim 15, the first section and the fourth section having the same number of struts. 18. The stent of claim 8, wherein each turn has a first width and each strut has a second width greater than the first width. 19. The stent of claim 18, wherein each connector has a third width substantially equal to the first width.
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