초록 ▼

Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are

Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are methods for making and using such medical compositions.

대표청구항 ▼

What is claimed is: 1. A demineralized bone matrix (DBM) composition, comprising: bioresorbable solids admixed with a liquid carrier to form a malleable implant composition, said bioresorbable solids present at a level of about 0.1 grams per cubic centimeter to about 0.7 grams per cubic centimeter

What is claimed is: 1. A demineralized bone matrix (DBM) composition, comprising: bioresorbable solids admixed with a liquid carrier to form a malleable implant composition, said bioresorbable solids present at a level of about 0.1 grams per cubic centimeter to about 0.7 grams per cubic centimeter of said composition; said bioresorbable solids comprising a particulate solid collagen material and a particulate solid DBM material, said particulate solid collagen material present in a weight ratio no less than 1:12 and no greater than 1:2 relative to said particulate solid DBM material; and said liquid carrier comprising an aqueous gel of alginate, wherein said alginate is present at a level of about 0.01 grams per cubic centimeter to about 0.1 grams per cubic centimeter of said composition. 2. The composition of claim 1, wherein: said bioresorbable solids are present at a level of about 0.1 g/cc to about 0.25 g/cc of said composition; said alginate is present at a level of about 0.01 g/cc to about 0.03 g/cc of said composition; and said composition is a flowable paste. 3. The composition of claim 1, wherein: said bioresorable solids are present at a level of about 0.2 g/cc to about 0.4 g/cc of said composition; said alginate is present at a level of about 0.02 g/cc to about 0.05 g/cc of said composition; and said composition is a shape-retaining putty. 4. The composition of claim 2, wherein said weight ratio of collagen material to DBM material is in the range of 1:10 to 1:5. 5. The composition of claim 3, wherein said weight ratio of collagen material to DBM material is in the range of 1:10 to 1:5. 6. The composition of claim 1, wherein said weight ratio is in the range of 1:12 to 1:5. 7. The composition of claim 1, wherein said weight ratio of collagen material to DBM material is in the range of 1:10 to 1:5. 8. The composition of claim 1, further comprising a mineral material wherein the mineral material is synthetic ceramic granules or mineralized bone chips.