Comfortable ophthalmic device and methods of its production
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G02C-007/02
G02C-007/04
A61F-002/16
출원번호
UP-0351907
(2006-02-10)
등록번호
US-7841716
(2011-01-31)
발명자
/ 주소
McCabe, Kevin P.
Steffen, Robert B.
Aguilar, Helene
Martin, W. Anthony
Neadle, Susan W.
Meyers, Ann-Marie W.
Vanderlaan, Douglas G.
Gourd, Dominic P.
Canavan, Kristy L.
Hill, Gregory A.
출원인 / 주소
Johnson & Johnson Vision Care, Inc.
인용정보
피인용 횟수 :
19인용 특허 :
98
초록▼
A method of providing a polymerized ophthalmic lens in which a polymerized ophthalmic lens is heated with a packaging solution comprising about 100 ppm to about 3,000 ppm of a wetting agent after its polymerization, and the ophthalmic lens formulation not having the wetting agent prior to its polyme
A method of providing a polymerized ophthalmic lens in which a polymerized ophthalmic lens is heated with a packaging solution comprising about 100 ppm to about 3,000 ppm of a wetting agent after its polymerization, and the ophthalmic lens formulation not having the wetting agent prior to its polymerization.
대표청구항▼
What is claimed is: 1. A method of providing a polymerized ophthalmic lens, comprising, heating a polymerized ophthalmic lens after its polymerization, with a packaging solution comprising about 100 ppm to about 3,000 ppm of a wetting agent to a temperature of at least about greater than 50°C.
What is claimed is: 1. A method of providing a polymerized ophthalmic lens, comprising, heating a polymerized ophthalmic lens after its polymerization, with a packaging solution comprising about 100 ppm to about 3,000 ppm of a wetting agent to a temperature of at least about greater than 50°C. to about 150° C., and the polymerized ophthalmic lens formulation does not comprise said wetting agent prior to its polymerization, wherein the packaging solution further comprises about 3700 ppm sodium borate. 2. The method of claim 1 wherein the wetting agent is selected from the group consisting of poly(meth)acrylamides, poly(itaconic acid), hyaluronic acid, xanthan gum, gum Arabic, starch, polymers of hydroxylalkyl(meth)acrylates, and polyvinylpyrrolidone. 3. The method of claim 1 wherein the wetting agent is selected from the group consisting of polyvinylpyrrolidone, graft co-polymers of polyvinylpyrrolidone, and co-polymers of polyvinylpyrrolidone. 4. The method of claim 1 wherein the wetting agent is polyvinylpyrrolidone. 5. The method of claim 4 wherein the K-value of the polyvinylpyrrolidone is about K-60 to about K-120. 6. The method of claim 4 wherein the K-value of the polyvinylpyrrolidone is about K-85 to about K-95. 7. The method of claim 4 wherein the K-value of polyvinylpyrrolidone is about K-90. 8. The method of claim 1 wherein the wetting agent comprises polyvinylpyrrolidone having a K-value of about K-85 to about K-95 and wherein heating is at a temperature of greater than about 120° C. 9. The method of claim 1 wherein the polymerized ophthalmic lens is heated at about 124° C. for about 18 minutes and with polyvinylpyrrolidone having a K-value of about K-90 at a concentration of about 400 to about 440 ppm. 10. The method of claim 1 wherein the polymerized ophthalmic lens is heated at about 121° C. for about 30 minutes and with polyvinylpyrrolidone having a K-value of about K-90 at a concentration of about 300 to about 400 ppm. 11. The method of claim 10 wherein the heating step is conducted in an individual sealed contact lens package. 12. The method of claim 9 wherein the heating step is conducted in an individual sealed contact lens package. 13. The method of claim 8 wherein the ophthalmic lens is selected from the group consisting of acofilcon A, alofilcon A, alphafilcon A, amifilcon A, astifilcon A, atalafilcon A, balafilcon A, bisfilcon A, bufilcon A, comfilcon, crofilcon A, cyclofilcon A, darfilcon A, deltafilcon A, deltafilcon B, dimefilcon A, drooxifilcon A, epsifilcon A, esterifilcon A, etafilcon A, focofilcon A, genfilcon A, govafilcon A, hefilcon A, hefilcon B, hefilcon D, hilafilcon A, hilafilcon B, hioxifilcon B, hioxifilcon C, hixoifilcon A, hydrofilcon A, lenefilcon A, licryfilcon A, licryfilcon B, lidofilcon A, lidofilcon B, lotrafilcon A, lotrafilcon B, mafilcon A, mesifilcon A, methafilcon B, mipafilcon A, nelfilcon A, netrafilcon A, ocufilcon A, ocufilcon B, ocufilcon C, ocufilcon D, ocufilcon E, ofilcon A, omafilcon A, oxyfilcon A, pentafilcon A, perfilcon A, pevafilcon A, phemfilcon A, polymacon, silafilcon A, siloxyfilcon A, tefilcon A, tetrafilcon A, trifilcon A, and xylofilcon A. 14. The method of claim 8 wherein the ophthalmic lens is selected from the group consisting of genfilcon A, lenefilcon A, lotrafilcon A, lotrafilcon B, balafilcon A, comfilcon, etafilcon A, nelfilcon A, hilafilcon, and polymacon. 15. The method of claim 8 wherein the ophthalmic lens is selected from the group consisting of etafilcon A, nelfilcon A, hilafilcon, and polymacon. 16. The method of claim 8 wherein the ophthalmic lens is selected from the group consisting of etafilcon A. 17. The method of claim 10 wherein the ophthalmic lens is an etafilcon A contact lens. 18. The method of claim 1 wherein the wetting agent is selected from the group consisting of poly(meth)acrylamides, poly(itaconic acid), hyaluronic acid, xanthan gum, gum Arabic, starch, polymers of hydroxylalkyl(meth)acrylates, and polyvinylpyrrolidone and wherein the polymerized ophthalmic lens is un-hydrated prior to heating said lens in said packaging solution. 19. The method of claim 18 wherein the wetting agent is selected from the group consisting of polyvinylpyrrolidone, graft co-polymers of polyvinylpyrrolidone, and co-polymers of polyvinylpyrrolidone. 20. The method of claim 18 wherein the wetting agent is polyvinylpyrrolidone. 21. The method of claim 20 wherein the polyvinylpyrrolidone has a K-value of about K-60 to about K-120. 22. The method of claim 21 wherein the polyvinylpyrrolidone has a K-value of about K-60 to about K-90. 23. The method of claim 18, further comprising a second step of heating the un-hydrated polymerized ophthalmic lens of claim 18 with a second portion of solution comprising a second wetting agent. 24. The method of claim 23 wherein the wetting agent is polyvinylpyrrolidone having a K-value of about K-60 and the second wetting agent is polyvinylpyrrolidone having a K-value of about K-90. 25. The method of claim 23 wherein the wetting agent is polyvinylpyrrolidone having a K-value of about K-90 and the second wetting agent is polyvinylpyrrolidone having a K-value of about K-90. 26. The method of claim 24 wherein the concentration of K60 is between about 30,000 ppm and about 150,000 ppm and the concentration of K90 is between about 100 ppm and about 500 ppm. 27. An ocular device comprising a polymerized ophthalmic lens and a wetting agent, wherein said polymerized ophthalmic lens is heated after its polymerization, with a packaging solution comprising about 100 ppm to about 3,000 ppm of a wetting agent to a temperature of at least about greater than 50° C. to about 150° C. and the polymerized ophthalmic lens formulation does not comprise said wetting agent prior to its polymerization wherein the wetting agent is selected from the group consisting of poly(meth)acrylamides, poly(itaconic acid), hyaluronic acid, xanthan gum, gum Arabic, starch, polymers of hydroxylalkyl(meth)acrylates, and polyvinylpyrrolidone. 28. The device of claim 27 wherein the wetting agent is selected from the group consisting of polyvinylpyrrolidone, graft co-polymers of polyvinylpyrrolidone, and co-polymers of polyvinylpyrrolidone. 29. The device of claim 27 wherein the wetting agent is polyvinylpyrrolidone. 30. The device of claim 27 comprising about 0.01 mg to about 1.0 mg polyvinylpyrrolidone. 31. The device of claim 27 comprising about 0.10 mg to about 0.44 mg of polyvinylpyrrolidone. 32. The device of claim 27 comprising about 0.01 mg to about 1.0 mg of a wetting agent selected from the group consisting of poly(meth)acrylamides, poly(itaconic acid), hyaluronic acid, xanthan gum, gum Arabic, starch, polymers of hydroxylalkyl(meth)acrylates, and polyvinylpyrrolidone. 33. The device of claim 27 comprising about 0.10 mg to about 0.44 mg of a wetting agent selected from the group consisting of poly(meth)acrylamides, poly(itaconic acid), hyaluronic acid, xanthan gum, gum Arabic, starch, polymers of hydroxylalkyl(meth)acrylates, and polyvinylpyrrolidone. 34. The device of claim 20 wherein the wetting agent is polyvinylpyrrolidone having a K-value of about K-60 to about K-90.
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