Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B32B-005/16
A61K-031/745
A61K-031/80
A61K-009/14
출원번호
UP-0236051
(2008-09-23)
등록번호
US-7842377
(2011-01-31)
발명자
/ 주소
Lanphere, Janel
St. Pierre, Ernest J.
Kapoglis, Greg
Casey, II, Thomas V.
출원인 / 주소
Boston Scientific Scimed, Inc.
대리인 / 주소
Fish & Richardson P.C.
인용정보
피인용 횟수 :
59인용 특허 :
310
초록▼
A composition includes a plurality of particles. At least some of the plurality of particles include cross-linked polyvinyl alcohol and have a diameter of about 500 microns or less. The particles have a first average pore size in an interior region, and a second average pore size at a surface region
A composition includes a plurality of particles. At least some of the plurality of particles include cross-linked polyvinyl alcohol and have a diameter of about 500 microns or less. The particles have a first average pore size in an interior region, and a second average pore size at a surface region. The first average pore size being greater than the second average pore size. The composition also includes a carrier fluid. The plurality of particles being in the carrier fluid.
대표청구항▼
What is claimed is: 1. A composition, comprising: a plurality of particles, at least some of the plurality of particles comprising cross-linked polyvinyl alcohol and having a diameter of about 500 microns or less, the at least some of the particles having a first average pore size in an interior re
What is claimed is: 1. A composition, comprising: a plurality of particles, at least some of the plurality of particles comprising cross-linked polyvinyl alcohol and having a diameter of about 500 microns or less, the at least some of the particles having a first average pore size in an interior region and a second average pore size at a surface region, the first average pore size being greater than the second average pore size; and a carrier fluid, the plurality of particles being in the carrier fluid. 2. The composition of claim 1, wherein the at least some of the particles have an average diameter of about 10 microns or more. 3. The composition of claim 1, wherein the at least some of the particles have an average diameter of about 100 microns or more. 4. The composition of claim 1, wherein the at least some of the particles have an average diameter of about 300 microns or less. 5. The composition of claim 1, wherein the at least some of the particles have an average diameter of about 300 microns or more. 6. The composition of claim 1, wherein the at least some of the particles are at least partially coated with a substantially bioabsorbable material. 7. The composition of claim 1, wherein the at least some of the particles have a density of from about 1.1 grams per cubic centimeter to about 1.4 grams per cubic centimeter. 8. The composition of claim 1, wherein the at least some of the particles have an average sphericity of about 0.9 or more. 9. The composition of claim 1, wherein, after compression to about 50 percent, the at least some of the particles have an average sphericity of about 0.9 or more. 10. The composition of claim 1, wherein the at least some of the particles comprise about 2.5 weight percent or less polysaccharide. 11. The composition of claim 10, wherein the polysaccharide comprises alginate. 12. The composition of claim 11, wherein the alginate has a guluronic acid content of about 60 percent or greater. 13. The composition of claim 1, wherein the at least some of the particles are substantially insoluble in DMSO. 14. The composition of claim 1, wherein the at least some of the particles are substantially free of animal-derived compounds. 15. The composition of claim 1, wherein the at least some of the particles have a first density of pores in the interior region and a second density of pores at a surface region, and the first density is different from the second density. 16. A composition, comprising: a plurality of particles, at least some of the plurality of particles comprising polysaccharide and having a diameter of about 500 microns or less, the at least some of the particles having an interior region defining pores and a surface region defining pores, the at least some of the particles having a first density of pores in the interior region and a second density of pores at the surface region, the first density being different from the second density, the at least some of the particles having a first average pore size in the interior region and a second average pore size at the surface region, and the first average pore size being greater than the second average pore size; and a carrier fluid, the plurality of particles being in the carrier fluid. 17. The composition of claim 16, wherein the at least some of the particles have an average diameter of about 10 microns or more. 18. The composition of claim 16, wherein the at least some of the particles have an average diameter of about 100 microns or more. 19. The composition of claim 18, wherein the at least some of the particles have an average diameter of about 300 microns or less. 20. The composition of claim 16, wherein the at least some of the particles have an average a diameter of about 300 microns or more. 21. The composition of claim 16, wherein the at least some of the particles comprise about 2.5 weight percent or less of the polysaccharide. 22. The composition of claim 21, wherein the polysaccharide comprises alginate. 23. The composition of claim 16, wherein the at least some of the particles further comprise cross-linked polyvinyl alcohol.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (310)
Graves David J. (Devon PA) Burns Mark A. (Fairfield NJ), Affinity chromatography using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized b.
Pluss-Wenzinger Raphael,CHX ; Widmer Fritz,CHX ; Heinzen Christoph,CHX ; Brandenberger Harry,CHX, Apparatus for encapsulating substances in small spherical particles formed from an encapsulating fluid.
Egli Walter (San Diego CA) Bailey ; Jr William H. (San Diego CA) Leary David F. ; (San Diego CA) Lansley Richard J. (Del Mar CA), Apparatus for producing microspherical particles and method for operating such apparatus.
Mitschker Alfred (Odenthal DEX) Lange Peter M. (Leverkusen WV DEX) Kreiss Wolfgang (New Martinsville WV), Bead-shaped crosslinked copolymers containing epoxide groups and basic amino groups, a process for their preparation and.
Eury Robert P. (Half Moon Bay CA) Patel Rajesh (San Mateo CA), Blocked polymeric particles having internal pore networks for delivering active substances to selected environments.
Zdeb Brian D. (Round Lake Park IL) Jepson Steven C. (Palatine IL), Cartridge and adapter for introducing a beneficial agent into an intravenous delivery system.
Kamiya Tetsuro (Suita) Echigo Shigeyuki (Toyonaka) Matsuda Takehisa (Mino) Yoda Ryuichiro (Yokohama) Satoh Nobuko (Kawasaki JPX), Closing plug of a defect for medical use and a closing plug device utilizing it.
Munteanu Marina A. (New York NY) Cseko Christine (Purchase NY) Oltarzewski Edward S. (Mercerville NJ) Lindauer Jerome I. (Hillsdale NJ) Withycombe Donald A. (Lincroft NJ), Cologne consisting of microcapsule suspension.
Leshchiner Adolf (Fairview NJ) Larsen Nancy E. (Southfield NY) Balazs Endre A. (Ft. Lee NJ) Hilal Sadek K. (Englewood Cliffs NJ), Compositions for therapeutic percutaneous embolization and the use thereof.
Modi Pankaj (1298 Main St. W. ; Apt. 608 Hamilton ; Ontario CAX L8S 1J4), Controlled release of drugs or hormones in biodegradable polymer microspheres.
Kolber Chris M. (Nashua NH) Bryant Peter L. (Lake Forest IL) Larkin Mark E. (Lindenhurst IL) Karas Peter J. (Libertyville IL) Ziegler John S. (Arlington Heights IL), Drug storage and delivery system.
Dormandy ; Jr. Ray (San Bruno CA) Berlo Marcelyn A. (San Francisco CA) Paul David J. (Pleasanton CA), Embolization device and apparatus including an introducer cartridge and a delivery catheter and method for delivering th.
Dormandy ; Jr. Ray H. (San Bruno CA) Berlo Marcelyn A. (San Francisco CA), Embolization device and apparatus including an introducer cartridge and method for delivering the same.
Conston Stanley R. (San Carlos CA) Dapper Gregory S. (Newark CA) Murphy Aileen L. (Menlo Park CA) Raeder-Devens Jennifer (Oakland CA) Yamamoto Ronald (San Francisco CA), Embolization plugs for blood vessels.
Kurz Daniel R. ; Wong Rose Y. ; Sein-Lwyn Crystal K. ; Ferrera David A. ; Lei Lok A. ; Debeer Nicholas C., Endoluminal device delivery system using axially recovering shape memory material.
Yan Feng,CHX ; Schneider Michel,CHX ; Brochot Jean,CHX, Gas mixtures useful as ultrasound contrast media contrast agents containing the media and method.
Yan Feng (Carouge CHX) Schneider Michel (Troinex CHX) Brochot Jean (Feigeres FRX), Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method.
Sefton Michael Vivian,CAX ; Babensee Julia E.,CAX ; May Michael H.,CAX, Generating blood vessels with angiogenic material containing a biocompatible polymer and polymerizable compound.
Takahashi Toru (Shizuoka-ken JPX) Nakamura Hideki (Kanagawa-ken JPX) Goto Katsuya (Fukuoka-ken JPX), High polymer gel and vascular lesion embolizing material comprising the same.
Torobin Leonard B. (Materials Technology Corporation ; 120 Interstate N. ; Parkway E. ; Suite 158 Atlanta GA 30339), Hollow porous microspheres as substrates and containers for catalyst.
Tice Thomas R. ; Staas Jay K. ; Ferrell Teresa M., Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol.
Thomas R. Tice ; Jay K. Staas ; Teresa M. Ferrell ; Peter Markland, Injectable opioid partial agonist or opioid antagonist microparticle compositions and their use in reducing consumption of abused substances.
Rhee Woonza M. ; Berg Richard A. ; Chu George H. ; DeLustro Frank A. ; Jolivette Dan M. ; McCullough Kimberly A., Injectable or implantable biomaterials for filling or blocking lumens and voids of the body.
Cohen Smadar (Petach-Tickva ILX) Bano Carmen (Valencia PA ESX) Visscher Karyn B. (State College PA) Chow Marie (Brookline MA) Allcock Harry R. (State College PA) Langer Robert S. (Newton MA), Ionically cross-linked polymeric microcapsules.
Cohen Smadar (Petach-Tickya ILX) Bano Carmen (Valencia PA ESX) Visscher Karyn B. (State College PA) Chow Marie (Brookline MA) Allcock Harry R. (State College PA) Langer Robert S. (Newton MA), Ionically cross-linked polymeric microcapsules.
Sancoff Gregory E. (Rancho Sante Fe CA) Doyle Mark C. (San Diego CA) Field Frederic P. (Solana Beach CA), Liquid delivery device having a vial attachment or adapter incorporated therein.
Barby Donald (Chester GB2) Haq Zia (Wirral GB2), Low density porous cross-linked polymeric materials and their preparation and use as carriers for included liquids.
Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D., Macromolecular microparticles and methods of production and use.
Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D. ; Riske Frank J., Macromolecular microparticles and methods of production and use.
Tschang Chung-Ji (Frankenthal DEX) Klefenz Heinrich (Hochdorf-Assenheim DEX) Sanner Axel (Frankenthal DEX), Macroporous polymeric carrier for covalently binding proteins, its preparation and its use for fixing active proteins.
Fritzberg Alan R. (Edmonds WA) Kasina Sudhakar (Kirkland WA) Srinivasan Ananthachari (Kirkland WA) Wilbur Daniel S. (Edmonds WA), Metal radionuclide labeled proteins for diagnosis and therapy.
Christoph Heinzen DE; Raphael Pluss-Wenzinger DE; Fritz Widmer DE; Harry Brandenberger DE, Method and device for capsulating microbial, plant and animal cells or biological and chemical substances.
Vrba Jiri (Port Coquitlam CAX) Haid Gordon James (Pitt Meadows CAX) Lee Wai Meng Sixtus (Coquitlam CAX) Taylor Brent Ronald (Coquitlam CAX) Tillotson Mark Alan (Maple Ridge CAX), Method and systems for obtaining higher order gradiometer measurements with lower order gradiometers.
March Keith L. (Carmel IN) Hathaway David R. (Indianapolis IN) Wilensky Robert L. (Indianapolis IN), Method for delivery of smooth muscle cell inhibitors.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Method of preparing gas and gaseous precursor-filled microspheres.
Liberti Paul A. (Huntingdon Valley PA) Rao Galla C. (Princeton NJ) Chiarappa Joseph N. (Flemington NJ), Methods for the manufacture of magnetically responsive particles.
Unger Evan C. ; Fritz Thomas A. ; Matsunaga Terry ; Ramaswami VaradaRajan ; Yellowhair David ; Wu Guanli, Methods of preparing gas and gaseous precursor-filled microspheres.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Methods of preparing gas-filled liposomes.
Klaveness Jo (Oslo NLX) Rongved Pal (Hellvik NLX) Stubberud Lars (Sodertalje NLX), Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging.
Stewart Ray F. (Redwood City CA) Greene Lawrence C. (Boulder Creek CA) Bhaskar Ravi K. (Lawrence KS), Microcapsule having temperature-dependent permeability profile.
Steiner Solomon S. ; Feldstein Robert ; Lian Huiling ; Rhodes Christopher A. ; Shen Gregory S., Microparticles for lung delivery comprising diketopiperazine.
Goldberg Eugene P. (Gainesville FL) Longo William E. (Gainesville FL) Iwata Hiroo (Suita JPX), Microspheres for incorporation of therapeutic substances and methods of preparation thereof.
Lee Chul-Joo,KRX ; Lyoo Won-Seok,KRX ; Kwon Ick-Chan,KRX ; Lee Se-Geun,KRX ; Kim Jae-Pil,KRX ; Han Moon-Hee,KRX, Microspheric embolic materials having a dual structure of poly(vinyl acetate) core and poly(vinyl alcohol) shell and method for preparing the same.
Rhim Won-Kyu (Pasadena CA) Hyson Michael T. (Glendale CA) Chung Sang-Kun (Diamond Bar CA) Colvin Michael S. (Malibu CA) Chang Manchium (Los Angeles CA), Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops.
Franses Elias I. (3732 Capilano Dr. West Lafayette IN 47906) Caruthers James M. (1210 Western West Lafayette IN 47906) Keville Kathleen M. (1155 Anthrop Dr. #3 West Lafayette IN 47906), Nonspherical microparticles and method therefor.
Matson, Louis R.; Brandom, Donald K., Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them.
Annonier Claude,FRX ; Autant Pierre,FRX ; Ruel Jacques,FRX ; Porte Hugues,FRX ; Laffay Jean-Claude,FRX ; Sabatier Alain,FRX, Pellets containing active ingredients protected against degradation in the rumen of ruminants.
Pasztor Emil (4 Rakoczi-u Budapest HUX 1072) Lazar Laszlo (4 ; Rozsahegy-u Budapest HUX 1024) Nagy Jozsef (46/b ; Trbalinti-u Budapest HUX 1122) Pallosy nee Becker Katalin (31 ; Vinceller-u ; Budapes, Pharmaceutically acceptable silicon rubber and therapeutical set and the use thereof for surgical embolization.
Pasztor, Emil; Lazar, Laszlo; Nagy, Jozsef; Pallosy nee Becker, Katalin, Pharmaceutically acceptable silicon rubber and therapeutical set and the use thereof for surgical embolization.
Psztor Emil (4 ; Rkczi-u Budapest HUX 1072) Lzr Lszl (4 ; Rzsahegy-u Budapest HUX 1024) Nagy Jzsef (46/b Trkblinti-u Budapest HUX 1122) Pllosy ne Becker Katalin (31 ; Vincellr-u Budapest HUX 1113), Pharmaceutically acceptable silicon rubber and therapeutical set and the use thereof for surgical embolization.
Hyon Suong-Hyu (Tamatsukurimotomachi JPX) Ikada Yoshito (Tamatsukurimotomachi JPX), Porous and transparent poly(vinyl alcohol) gel and method of manufacturing the same.
Itagaki Takaharu (Yokohama JPX) Kusano Hiroshi (Yokohama JPX) Miyata Eiji (Kitakyushu JPX) Tashiro Takayuki (Machida JPX), Porous cross-linked polyvinyl alcohol particles, process for producing the same, and separating agent composed of the sa.
Vanderhoff John W. (Bethlehem PA) Micale Fortunato J. (Bethlehem PA) El-Aasser Mohamed S. (Bethlehem PA) Tseng Chi-Ming (Bethlehem PA), Preparation of large particle size monodisperse latexes.
Faccioli Giovanni (Montova ITX) Soffiatti Renzo (Verona ITX), Process and apparatus for the mixing and direct emplacement of a two-component bone cement.
Frazza Mark S. (Philadelphia PA) Ho Kim S. (Richboro PA) Kowalski Alexander (Plymouth Meeting PA) Raney Robert R. (Newtown Square PA) Vogel Martin (Jenkintown PA), Process for making controlled, uniform-sized particles in the 1 to 50 micrometer range.
Chiou Shang-Jaw (Lower Gwynedd PA) Sheng Miao-Hsun L. (Lower Gwynedd PA) Hook ; III John W. (Warminster PA) Stevens Travis E. (Ambler PA), Process for preparing large dimension emulsion polymer particles, polymer product and uses thereof.
Kelley Donald J. (Lunenburg MA) Williams David J. (Lunenburg MA) Slovenkai Stephen V. (Leominster MA), Process for preparing styrenic polymer particles.
Timm Edward E. (Coleman MI) Leng Douglas E. (Midland MI), Process for preparing uniformly sized polymer particles by suspension polymerization of vibratorily excited monomers in.
Vanderhoff John W. ; Lu Cheng Xun ; Lee Clarence C. ; Tsai Chi-Chun, Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained.
Vanderhoff, John W.; Lu, Cheng Xun; Lee, Clarence C.; Tsai, Chi-Chun, Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained.
Lange Peter M. (Leverkusen DEX) Strver Werner (Cologne DEX), Process for the preparation of bead polymers of uniform particle size by polymerization of microencapsulated monomer.
Hattori Masayuki (Bethlehem PA) Sudol E. David (Bethlehem PA) El-Aasser Mohamed S. (Bethlehem PA), Process for the preparation of cross-linked polymer particles.
Bayer Ernst (Bei der Ochsenweide 17 D-7400 Tbingen DEX) Rapp Wolfgang (Ursrainer Ring 105 D-7400 Tbingen DEX), Process for the preparation of monodispersed polymer beads.
Stowell Donald E. (Oklahoma City OK) Jackson R. Tom (Ponca City OK) Bendig Larry L. (Ponca City OK), Production of high strength alumina spheres by hydrogelling corresponding slurries.
Rembaum Alan (Pasadena CA) Rhim Won-Kyu (Pasadena CA) Hyson Michael T. (Glendale CA) Chang Manchium (Los Angeles CA), Production of monodisperse, polymeric microspheres.
Takada Shigeyuki (Salt Lake City UT) Uda Yoshiaki (Takarazuka JPX) Ogawa Yasuaki (Kyoto JPX), Prolonged release microparticle preparation and production of the same.
Takada Shigeyuki (Salt Lake City UT) Uda Yoshiaki (Takarazuka JPX) Ogawa Yasuaki (Ohyamazaki-cho JPX), Prolonged release microparticle preparation and production of the same.
Lo Ray Jia (San Leandro CA) Villafranca Ernesto Noe (Oakland CA), Solid microspheres for agriculturally active compounds and process for their production.
Courteille Frederic (Cachan FRX) Coutel Anne (Antony FRX) Lebreton Guy (Gif-Sur-Yvette FRX) Veillard Michel (Sceaux FRX), Solid porous unitary form comprising micro-particles and/or nano-particles, and its preparation.
Cercone Ronald J. (East Lyme CT) Gatto Dom L. (Branford CT) Gertzman Arthur A. (Woodbridge CT) Valentine Douglas R. (Oakdale CT), Surgical sponge device.
Hofstetter John M. (Vernon Hills IL) O\Neil John A. (Mundelein IL) Grabenkort Richard W. (Barrington IL), Syringe system accommodating separately storable prefilled containers for two constituents.
Dormandy ; Jr. Ray H. (South San Francisco CA) Bell Julie D. (South San Francisco CA), System for artificial vessel embolization and devices for use therewith.
Unger Evan C. ; Fritz Thomas A. ; Matsunaga Terry ; Ramaswami VaradaRajan ; Yellowhair David ; Wu Guanli, Targeted gas and gaseous precursor-filled liposomes.
Ersek Robert A. (62 Pascal Austin TX 78746) Beisang ; III Arthur A. (5883 Carlson St. Shoreview MN 55126) Beisang Arthur A. (1300 Ingerson Rd. Arden Hills MN 55112), Textured micro implants.
Wallace Sidney (Houston TX) Yang David (Sugar Lan TX) Wallace Michael (Houston TX) Li Chun (Houston TX) Kuang Li-Ren (Houston TX), Therapeutic and diagnostic use of modified polymeric microcapsules.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Therapeutic delivery systems related applications.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Therapeutic drug delivery systems.
Kunz Lawrence L. ; Klein Richard A. ; Reno John M. ; Grainger David J.,GBX ; Metcalfe James C.,GBX ; Weissberg Peter L.,GBX ; Anderson Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
Kennedy Joseph P. (Akron OH) Puskas Judit E. (Akron OH) Kaszas Gabor (Akron OH) Hager William G. (Akron OH), Thermoplastic elastomers of isobutylene and process of preparation.
Ersek Robert A. (62 Pascal Austin TX 78746) Beisang Arthur A. (1300 Ingerson Rd. Arden Hills MN 55112) Beisang ; III Arthur A. (5883 Carlson St. Shoreview MN 55126), Treatment of urological and gastric fluid reflux disorders by injection of mmicro particles.
Hargrove William W. (Indianapolis IN) Harris Dale C. (Fairland IN) Akers Michael J. (Greenwood IN) Sperry Charles R. (Westport CT), Vacuum vial infusion system.
Morgan Tamela A. (Olmsted Township ; Cuyahoga County OH) Julian Gary L. (Parma OH) Stanislawczyk Vic (North Ridgeville OH), Vinylidene chloride emulsion interpolymer composition.
Rothberg, Jonathan M.; Bustillo, James; Milgrew, Mark James; Schultz, Jonathan; Marran, David; Rearick, Todd; Johnson, Kim L., Integrated sensor arrays for biological and chemical analysis.
Rothberg, Jonathan M.; Hinz, Wolfgang; Johnson, Kim L.; Bustillo, James; Leamon, John; Schultz, Jonathan, Methods and apparatus for measuring analytes using large scale FET arrays.
Inman, Christina E.; Mastroianni, Alexander; Hinz, Wolfgang; Li, Shifeng; Benson, Scott C., Methods and systems for point of use removal of sacrificial material.
Matulevich, Yury; Moon, Sung-Hwan; Choi, Jong-Seo; Kim, Jae-Hyuk; Lee, Chun-Gyoo; Kwon, Seung-Uk; Park, Yo-Han; Suh, Soon-Sung; Jeong, Chang-Ui, Negative active material for lithium battery, method of preparing the negative active material, and lithium battery employing the negative active material.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.