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Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • C07H-021/02
  • C07H-021/04
  • C12P-019/34
출원번호 UP-0051646 (2005-01-27)
등록번호 US-7842459 (2011-01-31)
발명자 / 주소
  • Ayalon-Soffer, Michal
  • Pollock, Sarah
  • Shemesh, Ronen
  • Sorek, Rotem
  • Levine, Zurit
  • Shaqed, Zipi
  • Toporik, Amir
  • Cojocaru, Gad S.
  • Dahary, Dvir
  • Kol, Guy
  • Akiva, Pinchas
  • Novik, Amit
  • Nemzer, Sergey
  • Diber, Alexander
  • Shklar, Maxim
  • Sella-Tavor, Osnat
  • Bazak, Lily
  • Farkash, Ariel
  • Cohen, Yossi
출원인 / 주소
  • Compugen Ltd.
대리인 / 주소
    Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
인용정보 피인용 횟수 : 4  인용 특허 : 52

초록

Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.

대표청구항 ▼

What is claimed is: 1. An isolated polynucleotide consisting of the sequence selected from the group consisting of SEQ ID NOs 869, and 876 or a polynucleotide at least 95% identical thereto. 2. An isolated polynucleotide consisting of SEQ ID NO. 6889. 3. A method for diagnosing lung cancer, com

이 특허에 인용된 특허 (52)

  1. Tkachuk Zenovy (Kiev SUX) Kvasyuk Eugeny (Kiev SUX) Matsuka Gennady (Kiev SUX) Mikhailopulo Igor (Kiev SUX), (2′-5′) oligoadenylate analogues useful as inhibitors of host-v5.-graft response.
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  2. Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Constance DEX), 2′,5′-phosphorothioate oligoadenylates and their covalent conjugates with polylysine.
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  3. Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR) Stirchak Eugene P. (Corvallis OR), Alpha-morpholino ribonucleoside derivatives and polymers thereof.
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  4. Agrawal Sudhir (Shrewsbury MA) Tang Jin-Yan (Shrewsbury MA), Aminoalkylphosphorothioamidate oligonucleotide deratives.
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  5. Agrawal Sudhir (Shrewsbury MA) Tang Jin-Yan (Shrewsbury MA), Aminoalkylphosphotriester oligonucleotide derivatives.
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  6. Zhang Hong ; Cowsert Lex M., Antisense modulation of caspase 3 expression.
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  7. De Mesmaeker Alain (Kaenerkinden CHX) Lebreton Jacques (Marseilles FRX) Waldner Adrian (Allschwil CHX) Cook Phillip D. (Carlsbad CA), Backbone modified oligonucleotide analogs.
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  8. Cook Phillip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA) Morvan Francois (Montpellier FRX), Backbone modified oligonucleotide analogs and solid phase synthesis thereof.
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  9. Cook Phillip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA) Vasseur Jean J. (San Marcos CA) Debart Francoise (Montpellier FRX), Backbone modified oligonucleotide analogues.
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  10. Sanghvi Yogesh S. (San Marcos CA) Cook Phillip D. (Vista CA), Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling.
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  11. Matteucci Mark D. (Burlingame CA) Cao Xiaodong (Carlsbad CA), Binding compentent oligomers containing unsaturated 3′,5′and 2′,5′linkages.
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  12. Cook Phillip D. (San Marcos CA) Teng Kelly (San Diego CA), Conjugated 4′-desmethyl nucleoside analog compounds.
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  13. Baxter Anthony D. (Northwich GB2) Baylis Eric K. (Stockport GB2) Collingwood Stephen P. (Westhoughton GB2) Taylor Roger J. (Stretford GB2) De Mesmaeker Alain (Kanerkinden CHX) Schmit Chantal (Basel C, Dinucleoside phosphinates and their pharmaceutical compositions.
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  14. Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Konstanz DEX), Dual action 2′,5′-oligoadenylate antiviral derivatives and uses thereof.
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  15. Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Constance DEX), Encapsulated 2′,5′-phosphorothioate oligoadenylates.
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  16. Cook Phillip D. (Carlsbad CA) Sanghvi Yogesh S. (Carlsbad CA), Heteroatomic oligonucleoside linkages.
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  17. Teng Kelly (San Diego CA) Sanghvi Yogesh S. (San Marcos CA) Cook Phillip Dan (San Marcos CA), Heteroatomic oligonucleoside linkages.
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  18. Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke She L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
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  19. Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke She L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
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  20. Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke Shee L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
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  21. Agrawal Sudhir (Shrewsbury MA) Tang Jin-Yan (Shrewsbury MA), Linear aminoalkylphosphoramidate oligonucleotide derivatives.
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  22. Matteucci Mark (Burlingame CA) Jones Robert J. (Daly City CA) Munger John (San Francisco CA), Modified internucleoside linkages having one nitrogen and two carbon atoms.
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  23. Beaton Graham (Boulder CO) Fisher Eric F. (Boulder CO), Modified oligonucleotides and intermediates useful in nucleic acid therapeutics.
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  24. Ts\o Paul O. P. (2117 Folkstone Rd. Lutherville MD 21093) Miller Paul S. (225 Hopkins Rd. Baltimore MD 21212), Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof.
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  25. Meyer ; Jr. Rich B. (Woodinville WA) Adams A. David (Snohomish WA) Petrie Charles R. (Woodinville WA), Oligo (aa 상세보기
  • Letsinger Robert L. (Wilmette IL) Gryaznov Sergei M. (San Mateo CA), Oligodeoxyribonucleotides including 3′-aminonucleoside-phosphoramidate linkages and terminal 3′-amino groups.
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  • Sanghvi Yogesh S. (Carlsbad CA) Cook Phillip D. (Carlsbad CA), Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms.
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  • Hecht Sidney M. (Charlottesville VA), Oligonucleotide N-alkylphosphoramidates.
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  • Bischofberger Norbert (San Carlos CA) Kent Ken (Mountain View CA) Wagner Rick (Burlingame CA) Buhr Chris (Daly City CA) Lin Kuei-Ying (Fremont CA), Oligonucleotide analogs capable of passive cell membrane permeation.
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  • Benner Steven A. (Grossmannstrasse 16 ; #7 CH-8049 Zurich CHX), Oligonucleotide analogs containing sulfur linkages.
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  • Matteucci Mark (Burlingame CA), Oligonucleotide analogs with novel linkages.
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  • Matteucci Mark (Burlingame CA), Oligonucleotide analogs with novel linkages.
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  • Huie Edward M. (Wilmington DE) Trainor George L. (Wilmington DE), Oligonucleotide analogs with sulfamate linkages.
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  • Weis Alexander Ludvik (Berwyn PA) Hausheer Frederick Herman (San Antonio TX) Chaturvedula Prasad Venkata Chala (Exton PA) Delecki Daniel Joseph (Radnor PA) Cavanaugh ; Jr. Paul Francis (West Chester , Oligonucleotide analogues containing phosphate diester linkage substitutes, compositions thereof, and precursor dinucleo.
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  • Chaturvedula Prasad Venkata Chala (Exton PA), Oligonucleotide dimers with amide linkages replacing phosphodiester linkages.
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  • Tullis Richard H. (La Jolla CA), Oligonucleotide therapeutic agent and method of making same.
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  • Cook Phillip D. (San Marcos CA) Hoke Glenn (Mt. Airy MD), Oligonucleotides having phosphorothioate linkages of high chiral purity.
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  • Froehler Brian (Belmont CA), Oligonucleotides with inverted polarity.
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  • Imbach Jean-Louis (Montpellier FRX) Gosselin Gilles J. M. (Montpellier FRX), Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon.
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  • Spielvogel Bernard F. (Raleigh NC) Sood Anup (Durham NC) Hall Iris H. (Chapel Hill NC) Shaw Barbara R. (Durham NC), Oligoribonucleoside and oligodeoxyribonucleoside boranophosphates.
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  • Nielsen Peter E. (Hjortevanget 509 DK 2980 Kokkedal DKX) Buchardt Ole (Sondergardsvej 73 DK 3500 Vaerlose DKX) Egholm Michael (Johnstrup Alle 3 DK 1923 Frederiksberg DKX) Berg Rolf H. (Strandvaenget , Peptide nucleic acids.
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  • Buchardt ; deceased Ole,DKX ; Buchardt ; legal representative by Dorte,DKX ; Egholm Michael ; Nielsen Peter Eigil,DKX ; Berg Rolf Henrik,DKX, Peptide nucleic acids having amino acid side chains.
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  • Buchardt ; deceased Ole,DKX ; Buchardt ; representative by Dorte,DKX ; Egholm Michael ; Nielsen Peter Eigil,DKX ; Berg Rolf Henrik,DKX, Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility.
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  • Maddry Joseph A. (Birmingham AL) Reynolds Robert C. (Birmingham AL) Secrist John A. (Birmingham AL) Montgomery John A. (Birmingham AL) Crooks Peter A. (Lexington KY), Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages.
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  • Caruthers Marvin H. (Boulder CO) Marshall William S. (Boulder CO) Brill Wolfgang (Freiburg DEX) Nielsen John (Horsholm DKX), Polynucleotide phosphorodithioate.
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  • Caruthers Marvin H. (Boulder CO) Marshall William S. (Boulder CO), Polynucleotide phosphorodithioates.
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  • Weis Alexander L. (Berwyn PA) Saha Ashis K. (Frazer PA) Hausheer Frederick H. (San Antonio TX), Process of linking nucleosides with a siloxane bridge.
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  • Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Sequence-specific binding polymers for duplex nucleic acids.
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  • Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Sequence-specific binding polymers for duplex nucleic acids.
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  • Agrawal, Sudhir; Tang, Jinyan, Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling.
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  • Summerton, James E.; Weller, Dwight D., Uncharged morpholino-based polymers having achiral intersubunit linkages.
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  • Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages.
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