IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0965385
(2007-12-27)
|
등록번호 |
US-7846202
(2011-01-31)
|
발명자
/ 주소 |
- Bates, Brian L.
- Ragheb, Anthony O.
- Fearnot, Neal E.
- Voorhees, III, William D.
- Kozma, Thomas G.
|
출원인 / 주소 |
- Cook Incorporated
- Med Institute, Inc.
|
대리인 / 주소 |
Brinks Hofer Gilson & Lione
|
인용정보 |
피인용 횟수 :
2 인용 특허 :
153 |
초록
▼
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posit
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, where the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 may be posited over the bioactive material layer 18, where the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
대표청구항
▼
The invention claimed is: 1. An implantable medical device comprising: an expandable metal vascular stent having at least one metal surface, the stent being composed of a base material; at least one coating layer comprising parylene or a parylene derivative that is positioned directly against the a
The invention claimed is: 1. An implantable medical device comprising: an expandable metal vascular stent having at least one metal surface, the stent being composed of a base material; at least one coating layer comprising parylene or a parylene derivative that is positioned directly against the at least one metal surface; at least one layer comprising a first bioactive material; wherein the at least one layer comprising the first bioactive material is positioned on the coating layer; and at least one layer of a porous layer comprising a first polymer positioned on the at least one layer comprising the first bioactive material; wherein upon implantation into a patient, the porous layer controls release of the bioactive agent from the at least one layer comprising the first bioactive material. 2. The medical device of claim 1, where the first polymer is a biostable polymer with a relatively low chronic tissue response selected from the group consisting of polyurethanes, silicones, and polyesters. 3. The medical device of claim 1, where the first polymer is a polyurethane. 4. The medical device of claim 1, where the base material is a biocompatible metal selected from the group consisting of stainless steel, nickel, silver, platinum, gold, titanium, tantalum, iridium, tungsten, nitinol, and inconel. 5. The medical device of claim 3, where the base material is a biocompatible metal selected from the group consisting of stainless steel, nickel, silver, platinum, gold, titanium, tantalum, iridium, tungsten, nitinol, and inconel. 6. The medical device of claim 5, where the base material is nitinol. 7. The medical device of claim 6, wherein the bioactive material is paclitaxel or a derivative thereof. 8. The medical device of claim 1, wherein the bioactive material is paclitaxel or a derivative thereof. 9. The medical device of claim 1, wherein the bioactive material is paclitaxel.
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