초록 ▼

A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybas

A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.

대표청구항 ▼

We claim: 1. A biocompatible, biodegradable composition for use in sealing a biological tissue of a living mammal, the composition comprising a hydrogel, the hydrogel being produced by mixing a first solution comprising an acrylated chitosan with a second solution comprising oxidized dextran to pro

We claim: 1. A biocompatible, biodegradable composition for use in sealing a biological tissue of a living mammal, the composition comprising a hydrogel, the hydrogel being produced by mixing a first solution comprising an acrylated chitosan with a second solution comprising oxidized dextran to produce a mixture comprising from about 1% to about 10% by weight of the acrylated chitosan that forms the hydrogel, wherein the acrylated chitosan has a degree of substitution of a chitosan backbone with acrylate groups in the range of from about 0.25 to about 0.5, and wherein the mixture, when applied to a biological tissue in need of sealing, forms a hydrogel within a minute after mixing thereby sealing the biological tissue. 2. The composition of claim 1 wherein the hydrogel is adapted to adhere to biological tissue of a living mammal, to adhesively seal the tissue. 3. The composition of claim 1 wherein the living mammal is a living human being. 4. The composition of claim 1 further comprising a dye material or a radio-opaque material. 5. The composition of claim 1 further comprising a therapeutic or protective agent. 6. The composition of claim 5, wherein the therapeutic or protective agent comprises an antimicrobial agent. 7. The composition of claim 5 wherein the therapeutic or protective agent comprises a peptide or a protein, a growth factor, or a bone morphogenic factor. 8. The composition of claim 5, wherein the therapeutic or protective agent comprises a bone powder or a bone substitute. 9. The composition of claim 5, wherein the therapeutic or protective agent comprises an anti-inflammatory agent. 10. The composition of claim 5, wherein the therapeutic or protective agent comprises an anti-cancer agent. 11. The composition of claim 5, wherein the therapeutic or protective agent comprises a radioactive material. 12. The composition of claim 1 wherein the acrylated chitosan concentration is about 3% to about 7% by weight. 13. The composition of claim 1, wherein the mixture comprises about 5% by weight of the acrylated chitosan. 14. The composition of claim 1, wherein the first solution comprises from about 1% to about 10% acrylated chitosan. 15. The composition of claim 1, wherein the degree of substitution is in the range from about 0.25 to about 0.45. 16. The composition of claim 1, wherein the degree of substitution is about 0.5.