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Bioabsorbable macromer compositions are provided including a diisocyanate-functional bioabsorbable polymer. In some embodiments, the diisocyanate-functional bioabsorbable polymer can be combined with a functionalized polyol. The resulting bioabsorbable macromer composition can be employed as an adhe

Bioabsorbable macromer compositions are provided including a diisocyanate-functional bioabsorbable polymer. In some embodiments, the diisocyanate-functional bioabsorbable polymer can be combined with a functionalized polyol. The resulting bioabsorbable macromer composition can be employed as an adhesive or sealant for medical/surgical uses.

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What is claimed is: 1. A bioabsorbable macromer composition comprising: a diisocyanate-functional bioabsorbable polymer of the general formula: R2-[A]v-R1-[A]v-R2  (II) wherein R1 is a polymer selected from the group consisting of polysaccharides and polyols, A is a bioabsorbable

What is claimed is: 1. A bioabsorbable macromer composition comprising: a diisocyanate-functional bioabsorbable polymer of the general formula: R2-[A]v-R1-[A]v-R2  (II) wherein R1 is a polymer selected from the group consisting of polysaccharides and polyols, A is a bioabsorbable group, R2 is an isocyanate group, and v is a number from 1 to 20; and at least one functionalized polyol of the formula R7-[(R8)n-R9]d  (VII) wherein R7 is a polyol, R8 is a bioabsorbable group, R9 is an isocyanate group, n is a number from 1 to 10, and d is a number from 2 to 4. 2. A bioabsorbable macromer composition as in claim 1, wherein the polyol of the diisocyanate-functional bioabsorbable polymer is selected from the group consisting of polyethylene oxide, polyethylene glycol, polypropylene glycol, polyethylene oxide-polypropylene oxide copolymers, polyethylene glycol-adipate, polyethylene glycol-polypropylene glycol copolymers, and combinations thereof. 3. A bioabsorbable macromer composition as in claim 1, wherein the polyol of the diisocyanate-functional bioabsorbable polymer comprises polyethylene glycol. 4. A bioabsorbable macromer composition as in claim 1, wherein the bioabsorbable group of the diisocyanate-functional bioabsorbable polymer is selected from the group consisting of lactic acid, glycolic acid, glycolide, lactide, ε-caprolactone, trimethylene carbonate, 1,4-dioxane-2-one, 1,3-dioxane-2-one, succinnic acid, adipic acid, sebacic acid, malonic acid, glutaric acid, azelaic acid, ethyl dichlorophosphate, sebacic acid anhydride, azelaic acid anhydride, and combinations thereof. 5. A bioabsorbable macromer composition as in claim 1, wherein the bioabsorbable group of the diisocyanate-functional bioabsorbable polymer is selected from the group consisting of lactide, glycolide, ε-caprolactone, p-dioxanone, trimethylene carbonate, and combinations thereof. 6. A bioabsorbable macromer composition as in claim 1, wherein v is a number from 1 to about 6. 7. A bioabsorbable macromer composition as in claim 1, wherein the functionalized polyol possesses diisocyanate functional groups. 8. A bioabsorbable macromer composition as in claim 1, wherein the functionalized polyol possesses diisocyanate functional groups selected from the group consisting of toluene diisocyanate, 4,4′-diphenylmethane diisocyanate, 4,4′-oxybis (phenyl isocyanate), 2,4,6-trimethyl-1-,3-phenylene diisocyanate, trimethylhexane diisocyanate, 1,6-hexamethylene diisocyanate and isophorone diisocyanate. 9. A bioabsorbable macromer composition as in claim 1, wherein the functionalized polyol possess bioabsorbable groups selected from the group consisting of lactic acid, glycolic acid, glycolide, lactide, ε-caprolactone, trimethylene carbonate, 1,4-dioxane-2-one, 1,3-dioxane-2-one, succinnic acid, adipic acid, sebacic acid, malonic acid, glutaric acid, azelaic acid, ethyl dichlorophosphate, sebacic acid anhydride, azelaic acid anhydride, and combinations thereof. 10. A bioabsorbable macromer composition as in claim 1, wherein the polyol of the functionalized polyol comprises sorbitol, the bioabsorbable group comprises lactide, and the bioabsorbable macromer composition further includes a biologically active agent. 11. A bioabsorbable macromer composition as in claim 1, wherein the polyol of the functionalized polyol comprises sorbitol, the bioabsorbable group comprises lactide, and the bioabsorbable macromer composition further comprises a medicinal agent. 12. A bioabsorbable macromer composition as in claim 1, wherein the polyol of the functionalized polyol comprises sorbitol, the bioabsorbable group comprises lactide, and the bioabsorbable macromer composition further comprises an enzyme.