Tissue adhesives and sealants and method for their use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/17
C08L-089/00
출원번호
UP-0712333
(2007-02-28)
등록번호
US-7858079
(2011-02-24)
발명자
/ 주소
Hadba, Ahmad R.
Stopek, Joshua B.
출원인 / 주소
Tyco Healthcare Group LP
인용정보
피인용 횟수 :
6인용 특허 :
10
초록
Compositions provided by mixing a biotin-containing component and an avidin-containing component are useful as an adhesive or sealant for medical/surgical uses.
대표청구항▼
What is claimed is: 1. A biocompatible composition comprising: a biocompatible biotin-containing component comprising a first polymer selected from the group consisting of polyethylene glycols and absorbable polymers, wherein the first polymer is functionalized with biotin; and a biocompatible avid
What is claimed is: 1. A biocompatible composition comprising: a biocompatible biotin-containing component comprising a first polymer selected from the group consisting of polyethylene glycols and absorbable polymers, wherein the first polymer is functionalized with biotin; and a biocompatible avidin-containing component comprising a second polymer selected from the group consisting of polyethylene glycols and absorbable polymers, wherein the second polymer is functionalized with avidin or streptavidin, wherein the composition is suitable for in vivo contact with tissue, wherein at least the first polymer or the second polymer is an absorbable polymer selected from the group consisting of polycaprolactone, poly-D,L-lactic acid, poly-L-lactic acid, poly(lactide-co-glycolide), poly(hydroxybutyrate), poly(hydroxybutyrate-co-valerate), polydioxanone, polyorthoester, polyanhydride, poly(glycolic acid), poly(glycolic acid-cotrimethylene carbonate), polyphosphoester, polyphosphoester urethane, polyglutamic acid, polyaspartic acid, absorbable cyanoacrylates, poly(trimethylene carbonate), copoly(ether-esters), polyalkylene oxalates, polyphosphazenes, polyiminocarbonates, aliphatic polycarbonates, and combinations thereof, and wherein the biotin-containing component and the avidin-containing component form a gel matrix when the two components are combined. 2. The biocompatible composition as in claim 1, wherein the biocompatible biotin-containing component comprises polyethylene glycol, and wherein the biotin-containing component has a molecular weight of from about 500 Daltons to about 5,000 Daltons. 3. The biocompatible composition as in claim 1, wherein the second polymer is functionalized with avidin. 4. The A biocompatible composition as in claim 1, wherein the second polymer is functionalized with streptavidin. 5. The biocompatible composition as in claim 1, wherein the biocompatible composition further comprises a bioactive agent. 6. A method for adhering tissue comprising: approximating a first tissue surface and a second tissue surface; and applying the biocompatible composition of claim 1 to the approximated first and second tissue surfaces to adhere the first tissue surface to the a second tissue surface. 7. A method for adhering a medical device to a tissue surface, the method comprising: approximating a medical device and a tissue surface; and applying the biocompatible composition of claim 1 to the medical device, to the tissue surface, or both, wherein applying the biocompatible composition adheres the medical device to the tissue surface. 8. A biocompatible composition comprising: a biocompatible biotin-containing component comprising a first polymer, wherein the first polymer is functionalized with biotin; and a biocompatible avidin-containing component comprising a second polymer, wherein the second polymer is functionalized with avidin or streptavidin, wherein the first polymer, the second polymer, or both, is selected from the group consisting of polycaprolactone, poly-D,L-lactic acid, poly-L-lactic acid, poly(lactide-co-glycolide), poly(hydroxybutyrate), poly(hydroxybutyrate-co-valerate), polydioxanone, polyorthoester, polyanhydride, poly(glycolic acid), poly(glycolic acid-cotrimethylene carbonate), polyphosphoester, polyphosphoester urethane, polyglutamic acid, polyaspartic acid, absorbable cyanoacrylates, poly(trimethylene carbonate), copoly(ether-esters), polyalkylene oxalates, polyphosphazenes, polyiminocarbonates, aliphatic polycarbonates, and combinations thereof, wherein the composition is suitable for in vivo contact with tissue, and wherein the biotin-containing component and the avidin-containing component form a gel matrix when the two components are combined.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (10)
Redl Heinz (Vienna ATX) Kriwetz Gert (Graz ATX), Apparatus for applying a tissue adhesive on the basis of human or animal proteins.
Schechter, Bilha; Arnon, Ruth; Wilchek, Meir, Modified avidin-type molecules as targeting agents for the liver and cells of the reticuloendothelial system.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.