초록 ▼

Methods for producing biocompatible compositions are provided. The biocompatible compositions include an isocyanate-functional polyurethane prepolymer in combination with a foam control agent. The foam control agent decreases the formation of bubbles and/or foam in the biocompatible composition, the

Methods for producing biocompatible compositions are provided. The biocompatible compositions include an isocyanate-functional polyurethane prepolymer in combination with a foam control agent. The foam control agent decreases the formation of bubbles and/or foam in the biocompatible composition, thereby enhancing the physical properties of the biocompatible composition. The presence of the foam control agent does not compromise the strength of the biocompatible composition. The compositions prepared by the methods of the present disclosure may be used as adhesives or sealants for medical/surgical uses.

대표청구항 ▼

What is claimed is: 1. A method comprising: reacting a first polyol selected from the group consisting of polyether polyols, polycaprolactone polyols, and polyhydric alcohols with a first polyisocyanate selected from the group consisting of aromatic, aliphatic and alicyclic diisocyanates, to produc

What is claimed is: 1. A method comprising: reacting a first polyol selected from the group consisting of polyether polyols, polycaprolactone polyols, and polyhydric alcohols with a first polyisocyanate selected from the group consisting of aromatic, aliphatic and alicyclic diisocyanates, to produce an isocyanate end-capped polyol; reacting the isocyanate end-capped polyol with a second polyol to produce a polyurethane; reacting the polyurethane with a second polyisocyanate to produce at least one isocyanate-functional polyurethane prepolymer; contacting the at least one isocyanate-functional polyurethane prepolymer with at least one foam control agent; applying the at least one isocyanate-functional polyurethane prepolymer with at least one foam control agent to tissue; and allowing the at least one isocyanate-functional polyurethane prepolymer to react with the tissue, wherein the at least one isocyanate-functional polyurethane prepolymer crosslinks upon contact with water in the tissue thereby forming a biocompatible composition possessing a strength profile that is not compromised by the presence of the foam control agent. 2. The method of claim 1, wherein the step of reacting the first polyol with the first polyisocyanate comprises reacting a first polyol selected from the group consisting of polyether polyols, polycaprolactone polyols, polyhydric alcohols, polyalkylene oxides, poloxamers, and combinations thereof. 3. The method of claim 1, wherein the step of reacting the first polyol with the first polyisocyanate comprises reacting a first polyol comprising the reaction product of a polyalkylene oxide in combination with an aliphatic dicarboxylic acid. 4. The method of claim 1, wherein the step of reacting the first polyol with the first polyisocyanate comprises utilizing a diisocyanate selected from the group consisting of 4,4′-oxybis(phenyl isocyanate), 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, 2,2′-diphenylmethane diisocyanate, 2,4′-diphenylmethane diisocyanate, 4,4′-diphenylmethane diisocyanate, diphenyldimethylmethane diisocyanate, dibenzyl diisocyanate, naphthylene diisocyanate, phenylene diisocyanate, xylylene diisocyanate, tetramethylxylylene diisocyanate, 2,4,6-trimethyl-1,3 phenylene diisocyanate, tetramethylene diisocyanate, hexamethylene diisocyanate, lysine diisocyanate, 2-methylpentane-1,5-diisocyanate, 3-methylpentane-1,5-diisocyanate, 2,2,4-trimethylhexamethylene diisocyanate, isophorone diisocyanate, cyclohexane diisocyanate, hydrogenated xylylene diisocyanate, hydrogenated diphenylmethane diisocyanate, hydrogenated trimethylxylylene diisocyanate, and combinations thereof. 5. The method of claim 1, wherein the step of reacting the first polyol with the first polyisocyanate comprises utilizing a diisocyanate selected from the group consisting of toluene diisocyanate, 4,4′-diphenylmethane diisocyanate, 1,6-hexamethylene diisocyanate, isophorone diisocyanate, and hexamethylene diisocyanate. 6. The method of claim 1, wherein the step of reacting the isocyanate end-capped polyol with a second polyol comprises utilizing a second polyol selected from the group consisting of ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, polyethylene glycol adipate, propylene glycol, dipropylene glycol, polypropylene glycol, tetraethylene glycol, 1,3-butanediol, 1,4-butanediol, 1,2,4-butanetriol, glycerol, trimethylol propane, 1,2,5-hexanetriol, 1,2,6-hexanetriol, polycaprolactone triol, polylactide triol, 4,4′-dihydroxyphenylpropane, 4,4′-dihydroxyphenylmethane, bis(hydroxyethyl)terephthalate, cyclohexane dimethanol, furan dimethanol, pentaerythritol, glucose, sucrose, sorbitol, polyethylene oxide copolymers with polypropylene oxide, and combinations thereof. 7. The method of claim 1, wherein the step of reacting the polyurethane with the second polyisocyanate comprises utilizing a diisocyanate selected from the group consisting of 4,4′-oxybis(phenyl isocyanate), 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, 2,2′-diphenylmethane diisocyanate, 2,4′-diphenylmethane diisocyanate, 4,4′-diphenylmethane diisocyanate, diphenyldimethylmethane diisocyanate, dibenzyl diisocyanate, naphthylene diisocyanate, phenylene diisocyanate, xylylene diisocyanate, tetramethylxylylene diisocyanate, 2,4,6-trimethyl-1,3 phenylene diisocyanate, tetramethylene diisocyanate, hexamethylene diisocyanate, lysine diisocyanate, 2-methylpentane-1,5-diisocyanate, 3-methylpentane-1,5-diisocyanate, 2,2,4-trimethylhexamethylene diisocyanate, isophorone diisocyanate, cyclohexane diisocyanate, hydrogenated xylylene diisocyanate, hydrogenated diphenylmethane diisocyanate, hydrogenated trimethylxylylene diisocyanate, and combinations thereof. 8. The method of claim 1, wherein the at least one foam control agent comprises a hydrophobic component, optionally in combination with a carrier vehicle, optionally in combination with an emulsifier. 9. The method of claim 8, wherein the hydrophobic component is selected from the group consisting of treated silica, waxes, silicones, silicone derivatives, diols, and combinations thereof. 10. The method of claim 8, wherein the carrier vehicle is selected from the group consisting of mineral oils, vegetable oils, silicone oils, alcohols, glycols, water, and combinations thereof, and the emulsifier is selected from the group consisting of ethoxylated alkylphenols, sorbitan esters, polyethylene glycol esters, and combinations thereof. 11. The method of claim 8, wherein the carrier vehicle is selected from the group consisting of liquid paraffin, mixtures of saturated hydrocarbons, cyclic hydrocarbons, almond oil, apricot kernel oil, avocado oil, castor oil, hydrogenated castor oil, coconut oil, hydrogenated coconut fatty glycerides, corn oil, evening primrose oil, jojoba oil, linseed oil, olive oil, palm oil, peanut oil, rapeseed oil, safflower oil, sesame oil, soybean oil, sunflower oil, wheat germ oil, cotton seed oil, palm kernel oil, polydimethyl siloxanes, cyclic dimethyl polysiloxanes, dimethiconol, ethanol, mannitol, sorbitol, glycerol, xylitol, propylene glycol, polypropylene glycol, ethylene glycol, polyethylene glycol, and combinations thereof, and the emulsifier is selected from the group consisting of nonylphenol ethoxylate, sorbitan tristearate, sorbitan sesquioleate, sorbitan monooleate, sorbitan laurate, sorbitan oleate, polyethylene glycol stearyl ether, polyethylene glycol stearate, polyethylene glycol distearate, polyethylene glycol palmitostearate, polyethylene glycol dilaurate, polyethylene glycol dioleate, and combinations thereof. 12. The method of claim 1, wherein the foam control agent is present in an amount from about 0.05% to about 2% by weight of the biocompatible composition. 13. A biocompatible adhesive comprising the biocompatible composition produced by the process of claim 1. 14. A biocompatible sealant comprising the biocompatible composition produced by the process of claim 1. 15. A method for closing a wound comprising: applying the biocompatible composition produced by the method of claim 1 to said wound; and allowing the biocompatible composition to set thereby closing said wound. 16. A method for filling a void in animal tissue comprising: applying the biocompatible composition produced by the method of claim 1 to said void; and allowing the biocompatible composition to set thereby filling said void. 17. A method for adhering a medical device to a surface of animal tissue comprising the steps of: applying the biocompatible composition produced by the method of claim 1 to said device, said surface or both; bringing the device, biocompatible composition and surface into contact with each other; and allowing the biocompatible composition to set thereby adhering the device and surface to each other.