$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/395
출원번호 US-0044749 (2005-01-27)
등록번호 US7862817 (2010-12-20)
발명자 / 주소
  • Adams, Camellia W.
  • Presta, Leonard G.
  • Sliwkowski, Mark
출원인 / 주소
  • Genentech, Inc.
대리인 / 주소
    Wendy M., Lee
인용정보 피인용 횟수 : 26  인용 특허 : 108

초록

The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.

대표청구항

What is claimed is: 1. A humanized antibody which binds ErbB2 and blocks ligand activation of an ErbB receptor and comprises the variable light (VL) domain amino acid sequence in SEQ ID NO: 3 and a variable heavy (VH) domain.

이 특허에 인용된 특허 (108)

  1. de Boer Mark (Beverwyle NLX) Conroy Leah B. (Pacifica CA), Anti-CD40 monoclonal antibodies capable of blocking B-cell activation.
    상세보기
  2. Fendly,Brian M., Anti-ErbB2 antibodies.
    상세보기
  3. King C. Richter (Washington DC) Kasprzyk Philip G. (Washington DC) Bird Robert E. (Rockville MD), Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof.
    상세보기
  4. Shawver Laura K. ; Brandis John W. ; Mann Elaina ; Hancock Miriam E. C. ; Mischak Ronald P. ; Monahan John J., Anti-neoplastic drugs in cancer therapy.
    상세보기
  5. Bissery Marie-Christine,FRX, Anti-tumor compositions containing taxane derivatives.
    상세보기
  6. Vandlen Richard L. ; Holmes William E., Antibodies specific for heregulin 2-.alpha..
    상세보기
  7. Senter Peter D. (Seattle WA) Saulnier Mark G. (Middletown CT) Brown Joseph P. (Seattle WA) Kerr David E. (Seattle WA), Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells.
    상세보기
  8. Arakawa Tsutomu ; Kita Yoshiko, Antibody-induced apoptosis.
    상세보기
  9. Tsutomu Arakawa ; Yoshiko Kita, Antibody-induced apoptosis.
    상세보기
  10. Ring David B., Antigen-binding sites of antibody molecules specific for cancer antigens.
    상세보기
  11. Bissery Marie-Christine,FRX, Antitumour compositions containing taxane derivatives.
    상세보기
  12. Plowman Gregory D., Assay for agents active in proliferative disorders.
    상세보기
  13. Ross Jeffrey S. ; Muraca Patrick J., Assessment of prostate cancer.
    상세보기
  14. An Gang ; O'Hara S. Mark ; Ralph David ; Veltri Robert, Biomarkers and targets for diagnosis, prognosis and management of prostate disease.
    상세보기
  15. Capon Daniel J. (Hillsborough CA) Weiss Arthur (Mill Valley CA) Irving Brian A. (San Francisco CA) Roberts Margo R. (San Francisco CA) Zsebo Krisztina (Woodside CA), Chimeric chains for receptor-associated signal transduction pathways.
    상세보기
  16. Greene Mark I. ; Qian Xiaolan, Compositions and methods of treating tumors.
    상세보기
  17. Mark I. Greene ; Donald M. O'Rourke ; Ramachandran Murali ; Byeong-Woo Park, Compositions and methods of treating tumors.
    상세보기
  18. Greene Mark I. (Penn Valley PA) Zhang Xin (Philadelphia PA), Compounds that bind to p185 and methods of using the same.
    상세보기
  19. Huston James S. ; Houston L. L. ; Ring David B. ; Oppermann Hermann, DNA encoding biosynthetic binding protein for cancer marker.
    상세보기
  20. Kraus Matthias H. (Bethesda MD) Aaronson Stuart A. (Vienna VA), DNA segment encoding a gene for a receptor related to the epidermal growth factor receptor.
    상세보기
  21. Carney Walter P. (North Andover MA) McKenzie Sara J. (Lynn MA), Detection and quantification of neu related proteins in the biological fluids of humans.
    상세보기
  22. Carney, Walter P.; McKenzie, Sara J.; Weinberg, Robert A., Detection of neu p185 in cell lysates.
    상세보기
  23. Bargmann Cornelia I. (Arlington MA) Weinberg Robert A. (Brookline MA), Detection of point mutations in neu genes.
    상세보기
  24. Slamon Dennis J. (Woodland Hills CA) McGuire William L. (San Antonio TX), Determination of status in neoplastic disease.
    상세보기
  25. Baughman, Sharon A.; Shak, Steven, Dosages for treatment with anti-ErbB2 antibodies.
    상세보기
  26. Baughman,Sharon A.; Shak,Steven, Dosages for treatment with anti-ErbB2 antibodies.
    상세보기
  27. Akita Robert ; Sliwkowski Mark, ErbB3 antibodies.
    상세보기
  28. Carter Paul J. (San Francisco CA), Expression of functional antibody fragments.
    상세보기
  29. Schaefer Gabriele Maria ; Sliwkowski Mark, Gamma-heregulin.
    상세보기
  30. Jensen Ronald H. ; Cher Michael L., Genetic alterations associated with prostate cancer.
    상세보기
  31. Hudziak Robert Michael ; Shepard H. Michael ; Ullrich Axel, HER2 extracellular domain.
    상세보기
  32. Hudziak Robert Michael ; Shepard H. Michael ; Ullrich Axel,DEX, HER2 extracellular domain.
    상세보기
  33. Marks James D. ; Schier Robert, High affinity human antibodies to tumor antigens.
    상세보기
  34. Marks, James D.; Schier, Robert, High affinity human antibodies to tumor antigens.
    상세보기
  35. Adair,John Robert; Athwal,Diljeet Singh; Emtage,John Spencer, Humanised antibodies.
    상세보기
  36. Adams, Camellia W.; Presta, Leonard G.; Sliwkowski, Mark, Humanized anti-ERBB2 antibodies and treatment with anti-ERBB2 antibodies.
    상세보기
  37. Sliwkowski, Mark, Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies.
    상세보기
  38. Carter Paul J. ; Presta Leonard G., Humanized antibodies and methods for making them.
    상세보기
  39. Mendelsohn John (La Jolla CA) Kawamoto Tomoyuki (Hiroshima NY JPX) Sato Gordon (Lake Placid NY) Sato J. Denry (Duarte CA), Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor.
    상세보기
  40. Cheever Martin A. ; Disis Mary L., Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is a.
    상세보기
  41. Cheever Martin A. ; Disis Mary L., Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is a.
    상세보기
  42. Cheever Martin A. ; Disis Mary L., Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the her-2/neu oncogene is a.
    상세보기
  43. Cheever Martin A. ; Disis Mary L., Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated.
    상세보기
  44. Carter Paul J. ; Presta Leonard G., Immunoglobulin variants.
    상세보기
  45. Benz Christopher C. ; Papahadjopoulos Demetrios P. ; Park John W. ; Hong Keelung ; Kirpotin Dmitri, Immunoliposomes that optimize internalization into target cells.
    상세보기
  46. Hudziak Robert M. ; Ullrich Axel ; Fendly Brian M., In vivo tumor detection assay.
    상세보기
  47. Kraus Matthias H. (Bethesda MD) Aaronson Stuart A. (Vienna VA), Isolated polypeptide erbB-3, related to the epidermal growth factor receptor and antibody thereto.
    상세보기
  48. Greene Mark I. (Penn Valley PA) Dobashi Kunio (Gunma PA JPX) Davis James G. (Philadelphia PA) Hamuro Junji (Yokahama JPX), Ligand for the neu gene product.
    상세보기
  49. Lippman Marc E. (Bethesda MD) Lupu Ruth (Gaithersburg MD), Ligand growth factors that bind to the erbB-2 receptor protein and induce cellular responses.
    상세보기
  50. Deborah R. Jaffee ; Kerry J. Flom, Method and kit for the prognostication of breast cancer.
    상세보기
  51. Carter, Paul J.; Presta, Leonard G., Method for making humanized antibodies.
    상세보기
  52. Carter, Paul J.; Presta, Leonard G., Method for making humanized antibodies.
    상세보기
  53. Carter, Paul J.; Presta, Leonard G., Method for making humanized antibodies.
    상세보기
  54. Paul J. Carter ; Leonard G. Presta, Method for making humanized antibodies.
    상세보기
  55. Bacus Sarah S. (Hinsdale IL), Method for prognosticating response to cancer therapy.
    상세보기
  56. Vandlen Richard L. (Hillsborough CA) Holmes William E. (Pacifica CA), Method for purifying heregulin.
    상세보기
  57. Wang Mary Ge ; George ; Jr. Albert Louis ; Light Elizabeth Sophia, Method for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue.
    상세보기
  58. Danenberg, Kathleen D., Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates.
    상세보기
  59. Vandlen Richard L. ; Holmes William E., Method of using HRG2-.alpha. to stimulate P185.sup.HeR2.
    상세보기
  60. Bacus Sarah S. (Hinsdale IL), Methods and compositions for cancer therapy and for prognosticating responses to cancer therapy.
    상세보기
  61. Koski Raymond A., Methods and compositions for determining HER-2/neu expression using monoclonal antibodies.
    상세보기
  62. Cheever Martin A. ; Disis Mary L., Methods for eliciting or enhancing reactivity to HER-2/neu protein.
    상세보기
  63. Curiel David T. ; Deshane Jessy, Methods for modulating protein function in cells using intracellular antibody homologues.
    상세보기
  64. Curiel David T. ; Deshane Jessy, Methods for modulating protein function in cells using, intracellular antibody homologues.
    상세보기
  65. Thorpe Philip E. ; Burrows Francis J., Methods for targeting the vasculature of solid tumors.
    상세보기
  66. Bishop Walter R. ; Brassard Diana L. ; Nagabhushan Tattanahalli L., Methods of inducing cancer cell death and tumor regression.
    상세보기
  67. Greene Mark I., Methods of treating cancerous cells with anti-receptor antibodies.
    상세보기
  68. Erickson,Sharon; Schwall,Ralph; Sliwkowski,Mark; Blattler,Walter, Methods of treatment using anti-ErbB antibody-maytansinoid conjugates.
    상세보기
  69. Frankel Arthur E. (Durham NC) Ring David B. (Redwood City CA) Laird Walter (Pinole CA), Monoclonal anti-human breast cancer antibodies.
    상세보기
  70. Frankel Arthur E. (Palo Alto CA) Ring David B. (Redwood City CA) Bjorn Michael J. (Hercules CA), Monoclonal anti-human breast cancer antibodies.
    상세보기
  71. Hudziak Robert M. (Corvallis OR) Shepard H. Michael (Rancho Santa Fe CA) Ullrich Axel (Portola Valley CA) Fendly Brian M. (Half Moon Bay CA), Monoclonal antibodies directed to the HER2 receptor.
    상세보기
  72. Hudziak Robert M. ; Shepard H. Michael ; Ullrich Axel ; Fendly Brian M., Monoclonal antibodies directed to the HER2 receptor.
    상세보기
  73. Hudziak Robert M. ; Shepard H. Michael ; Ullrich Axel ; Fendly Brian M., Monoclonal antibodies directed to the HER2 receptor.
    상세보기
  74. Hudziak Robert M. ; Shepard H. Michael ; Ullrich Axel ; Fendly Brian M., Monoclonal antibodies directed to the HER2 receptor.
    상세보기
  75. Hudziak Robert M. ; Ullrich Axel ; Fendly Brian M., Monoclonal antibodies directed to the HER2 receptor.
    상세보기
  76. Robert M. Hudziak ; H. Michael Shepard ; Axel Ullrich ; Brian M. Fendly, Monoclonal antibodies directed to the HER2 receptor.
    상세보기
  77. Robert M. Hudziak ; H. Michael Shepard ; Axel Ullrich ; Brian M. Fendly, Monoclonal antibodies directed to the HER2 receptor.
    상세보기
  78. Hudziak Robert M. ; Shepard H. Michael ; Ullrich Axel ; Fendly Brian M., Monoclonal antibodies directed to the her2 receptor.
    상세보기
  79. Vandlen Richard L. ; Holmes William E., Nucleic acids vectors and host cells encoding and expressing heregulin 2-.alpha..
    상세보기
  80. Vandlen Richard L. ; Holmes William E., Nucleic acids, vectors and host cells encoding heregulin.
    상세보기
  81. Andya James ; Cleland Jeffrey L. ; Hsu Chung C. ; Lam Xanthe M. ; Overcashier David E. ; Shire Steven J. ; Yang Janet Yu-Feng ; Wu Sylvia Sau-Yan, Protein formulation.
    상세보기
  82. Andya, James; Cleland, Jeffrey L.; Hsu, Chung C.; Lam, Xanthe M.; Overcashier, David E.; Shire, Steven J.; Yang, Janet Yu-Feng; Wu, Sylvia Sau-Yan, Protein formulation.
    상세보기
  83. Cleland, Jeffrey L.; Hsu, Chung C.; Lam, Xanthe M.; Overcashier, David E.; Yang, Janet Yu-Feng, Protein formulation.
    상세보기
  84. Blank Gregory S., Protein purification.
    상세보기
  85. Blank, Gregory S., Protein purification.
    상세보기
  86. Carol D. Basey ; Greg S. Blank, Protein purification.
    상세보기
  87. Carol D. Basey ; Greg S. Blank, Protein purification.
    상세보기
  88. Carol D. Basey ; Greg S. Blank, Protein purification.
    상세보기
  89. Blank Gregory S., Protein purification by Protein A chromatography.
    상세보기
  90. King C. Richter ; Kraus Matthias H. ; Aaronson Stuart A., Protein related to but distinct from EGF receptor and antibodies reactive therewith.
    상세보기
  91. Slamon Dennis J. ; Press Michael F., Quantitative measurement of tissue protein identified by immunohistochemistry and standardized protein determination.
    상세보기
  92. Wels Winfried S. (Basel CHX) Hynes Nancy E. (Basel CHX) Harweth Ina-Maria (Grenzach-Wyhlen DEX) Groner Bernd (Basel CHX) Hardman Norman (Riehen CHX) Zwickl Markus (Basel CHX), Recombinant antibodies specific for a growth factor receptor.
    상세보기
  93. Wels Winfried Stephan,CHX ; Hynes Nancy E.,CHX ; Harwerth Ina-Maria,DEX ; Groner Bernd,CHX ; Hardman Norman,CHX ; Zwickl Markus,CHX, Recombinant antibodies specific for a growth factor receptor.
    상세보기
  94. Erickson, Sharon; King, Kathleen; Schwall, Ralph, Rodent HER2 tumor model.
    상세보기
  95. Vandlen Richard L. (Hillsborough CA) Holmes William E. (Pacifica CA), Structure, production and use of heregulin.
    상세보기
  96. Anderson Darrell R. ; Hanna Nabil ; Leonard John E. ; Newman Roland A. ; Reff Mitchell E. ; Rastetter William H., Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen.
    상세보기
  97. Deo Yashwant M. ; Goldstein Joel ; Graziano Robert ; Somasundaram Chezian, Therapeutic compounds comprised of anti-Fc receptor antibodies.
    상세보기
  98. Deo Yashwant M. ; Goldstein Joel ; Graziano Robert ; Somasundaram Chezian, Therapeutic compounds comprised of anti-Fc receptor antibodies.
    상세보기
  99. Yashwant M. Deo ; Joel Goldstein ; Robert Graziano ; Chezian Somasundaram, Therapeutic compounds comprised of anti-Fc receptor antibodies.
    상세보기
  100. Deo Yashwant M. ; Graziano Robert ; Keler Tibor, Therapeutic multispecific compounds comprised of anti-Fc.alpha. receptor antibodies.
    상세보기
  101. Andrew J. Dannenberg ; Kotha Subbaramaiah, Treating cancers associated with overexpression of HER-2/neu.
    상세보기
  102. Sliwkowski,Mark X., Treating prostate cancer with anti-ErbB2 antibodies.
    상세보기
  103. Greene Mark I. ; Drebin Jeffrey A., Treatment of tumors with monoclonal antibodies against oncogene antigens.
    상세보기
  104. Adams,Camellia W.; Presta,Leonard G.; Sliwkowski,Mark, Treatment with anti-ErbB2 antibodies and anti-hormonal compounds.
    상세보기
  105. Adams,Camellia W.; Presta,Leonard G.; Sliwkowski,Mark, Treatment with anti-ErbB2 antibodies and chemotherapeutic agents.
    상세보기
  106. Adams,Camellia W.; Presta,Leonard G.; Sliwkowski,Mark, Treatment with anti-ErbB2 antibody combinations.
    상세보기
  107. Vogel Charles L. ; Bellet Robert E., Use of docetaxel for treating cancers.
    상세보기
  108. King C. Richter ; Kraus Matthias H. ; Aaronson Stuart A., erbB-2 gene segments, probes, recombinant DNA and kits for detection.
    상세보기

이 특허를 인용한 특허 (26)

  1. Roschke, Viktor; Lafleur, David; Hilbert, David M.; Kiener, Peter, Ang-2-binding modular recognition domain complexes and pharmaceutical compositions thereof.
    상세보기
  2. Andya, James; Gwee, Shiang C.; Liu, Jun; Shen, Ye, Antibody formulations.
    상세보기
  3. Barbas, III, Carlos F., Antibody targeting through a modular recognition domain.
    상세보기
  4. Weisser, Nina E.; Ng, Gordon Yiu Kon; Wickman, Grant Raymond; Dixit, Surjit Bhimarao; Escobar-Cabrera, Eric; Sanches, Mario, Bispecific antigen-binding constructs targeting HER2.
    상세보기
  5. Harris, Reed J.; Motchnik, Paul A., Composition comprising antibody that binds to domain II of HER2 and acidic variants thereof.
    상세보기
  6. Harris, Reed J.; Motchnik, Paul A., Composition comprising antibody that binds to domain II of HER2 and acidic variants thereof.
    상세보기
  7. Blättler, Walter A.; Chari, Ravi V. J., Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents.
    상세보기
  8. Chari, Ravi V. J.; Blättler, Walter A., Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents.
    상세보기
  9. Barbas, III, Carlos F., EFGR antibodies comprising modular recognition domains.
    상세보기
  10. Roschke, Viktor; Lafleur, David; Hilbert, David M.; Kiener, Peter, EGFR-binding modular recognition domains.
    상세보기
  11. Barbas, III, Carlos F., ERBB2 antibodies comprising modular recognition domains.
    상세보기
  12. Derynck, Mika K.; Kelsey, Stephen M., Extending time to disease progression or survival in cancer patients.
    상세보기
  13. Allison, David E.; Bruno, Rene; Lu, Jian-Feng; Ng, Chee M., Fixed dosing of HER antibodies.
    상세보기
  14. Kao, Yung-Hsiang; Vanderlaan, Martin, HER2 antibody composition.
    상세보기
  15. Chari, Ravi V. J.; Widdison, Wayne C., Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates.
    상세보기
  16. Chari, Ravi; Widdison, Wayne, Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates.
    상세보기
  17. Steeves, Rita M.; Chari, Ravi V. J.; Blattler, Walter A., Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates.
    상세보기
  18. Steeves, Rita M.; Chari, Ravi V. J.; Blattler, Walter A., Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates.
    상세보기
  19. Andya, James; Gwee, Shiang C.; Liu, Jun; Shen, Ye, Method of treating cancer with a pharmaceutical formulation comprising a HER2 antibody.
    상세보기
  20. Blättler, Walter; Chari, Ravi V. J., Methods of treatment using anti-ERBB antibody-maytansinoid conjugates.
    상세보기
  21. Barbas, III, Carlos F., Multispecific antibody targeting and multivalency through modular recognition domains.
    상세보기
  22. Gennaro, Lynn A.; Kao, Yung-Hsiang; Zhang, Yonghua, Pertuzumab variants and evaluation thereof.
    상세보기
  23. Gennaro, Lynn A.; Kao, Yung-Hsiang; Zhang, Yonghua, Pertuzumab variants and evaluation thereof.
    상세보기
  24. Roschke, Viktor; Lafleur, David; Hilbert, David M.; Kiener, Peter, Polynucleotides encoding angiopoietin-2 (ang-2) binding polypeptides.
    상세보기
  25. Amler, Lukas C.; Birkner, Merrill; Lin, Chin-Yu; Moecks, Joachim; Strauss, Andreas, Predicting response to a HER inhibitor.
    상세보기
  26. Barbas, III, Carlos F., VEGF antibodies comprising modular recognition domains.
    상세보기

관련 콘텐츠

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로