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Antibodies to fibroblast growth factor-like polypeptides 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/395
출원번호 US-0270449 (2008-11-13)
등록번호 US7879323 (2011-01-18)
발명자 / 주소
  • Thomason, Arlen
  • Liu, Benxian
출원인 / 주소
  • Amgen Inc.
대리인 / 주소
    McDonnell Boehnen Hulbert & Berghoff LLP
인용정보 피인용 횟수 : 18  인용 특허 : 28

초록 ▼

The present invention provides novel Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptides. Also provided for are methods for the diagnosis and tr

대표청구항 ▼

What is claimed is: 1. An antibody or fragment thereof that specifically binds:(a) the amino acid sequence of SEQ ID NO: 2;(b) the amino acid sequence of SEQ ID NO: 5;(c) the amino acid sequence of SEQ ID NO: 2 having an amino-terminal methionine;(d) the amino acid sequence of SEQ ID NO: 5 having an

이 특허에 인용된 특허 (28)

  1. Kim Jin-Seok (Salt Lake City UT) Maruyama Atsushi (Yokohama JPX) Akaike Toshihiro (Tokyo JPX) Kim Sung Wan (Salt Lake City UT), Cationic polymer and lipoprotein-containing system for gene delivery.
    상세보기
  2. Edwards, Jean-Baptiste Dumas Milne; Jobert, Severin; Giordano, Jean-Yves, EST's and encoded human proteins.
    상세보기
  3. Itoh, Nobuyuki; Kavanaugh, Michael, Human FGF-21 nucleic acids.
    상세보기
  4. Itoh,Nobuyuki; Kavanaugh,W Michael, Human FGF-21 polypeptides.
    상세보기
  5. David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
    상세보기
  6. Aebischer Patrick (Providence RI) Galletti Pierre M. (Providence RI) Panol George (Warwick RI) Miracoli Luigi (Genoa ITX), Implantable delivery system for biological factors.
    상세보기
  7. Aebischer Patrick (Providence RI) Winn Shelley R. (Providence RI) Galletti Pierre M. (Providence RI), In vivo delivery of neurotransmitters by implanted, encapsulated cells.
    상세보기
  8. Mak Tak W. (Toronto CAX), Knockout mice.
    상세보기
  9. Chang Donald C. (Houston TX), Method for inserting foreign genes into cells using pulsed radiofrequency.
    상세보기
  10. Chappel Scott C. (Jamaica Plain MA), Method for the modification of the expression characteristics of an endogenous gene of a given cell line.
    상세보기
  11. Sanford John C. (Geneva NY) Wolf Edward D. (Ithaca NY) Allen Nelson K. (Newfield NY), Method for transporting substances into living cells and tissues and apparatus therefor.
    상세보기
  12. Brigham Kenneth L. (Nashville TN), Method of in vivo delivery of functioning foreign genes.
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  13. Aslam Muhammed (Rochester NY) Light William (Victor NY), Method of making a projection viewable transparency comprising an electrostatographic toner image.
    상세보기
  14. Roninson Igor B. (818 S. Laflin St. Chicago IL 60607) Holzmayer Tatyana (1451 W. Flournoy St. ; Apt. 2E Chicago IL 60607) Choi Kyunghee (1121 Albion St. ; Apt. 806 Denver CO 80220), Methods and applications for efficient genetic suppressor elements.
    상세보기
  15. Roninson Igor B. ; Holzmayer Tatyana ; Kyunghee Choi ; Gudkov Andrei, Methods and applications for efficient genetic suppressor elements.
    상세보기
  16. Wurm Florian M. (Strasbourg FRX) Jordan Martin (San Bruno CA), Methods for calcium phosphate transfection.
    상세보기
  17. Zhang Ke ; Pacifici Robert, Methods for identifying novel secreted mammalian polypeptides.
    상세보기
  18. Aebischer Patrick (Providence RI) Winn Shelley R. (Providence RI), Neurological therapy devices.
    상세보기
  19. Davis Frank F. (19 Farmingdale Rd. East Brunswick NJ 08816) Van Es Theodorus (313 Overbrook Rd. Piscataway NJ 08854) Palczuk Nicholas C. (45 W. Franklin St. Bound Brook NJ 08805), Non-immunogenic polypeptides.
    상세보기
  20. Harris J. Milton (Huntsville AL) Sedaghat-Herati M. R. (Huntsville AL), Preparation and use of polyethylene glycol propionaldehyde.
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  21. Vegeto Elisabetta (7707 Eads Ave. LaJolla CA 92037) McDonnell Donald P. (10382 Rue Riviere Verte San Diego CA 92131) O\Malley Bert W. (629 Ramblewood Houston TX 77079), Progesterone receptor having C. terminal hormone binding domain truncations.
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  22. Cabilly Shmuel (Monrovia CA) Heyneker Herbert L. (Burlingame CA) Holmes William E. (Pacifica CA) Riggs Arthur D. (La Verne CA) Wetzel Ronald B. (San Francisco CA), Recombinant immunoglobin preparations.
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  23. Eglitis Martin (McLean VA) Thompson J. Anthony (Birmingham AL) Anderson W. French (Bethesda MD), Retroviral vectors.
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  24. Kriegler Michael (Ambler PA) McCormick Francis P. (Albany CA), Retroviral vectors expressing cytokines.
    상세보기
  25. Bujard Hermann (Heidelberg DEX) Gossen Manfred (El Cerrito DEX) Hillen Wolfgang (Erlangen DEX) Helbl Vera (Fuerth DEX) Schnappinger Dirk (Bad Driburg DEX), Tetracycline regulated transcriptional modulators with altered DNA binding specificities.
    상세보기
  26. Bujard Hermann (Heidelberg DEX) Gossen Manfred (Berkeley CA), Tetracycline-inducible transcriptional activator and tetracycline-regulated transcription units.
    상세보기
  27. Bujard Hermann (Heidelberg DEX) Gossen Manfred (Heidelberg DEX) Salfeld Jochen G. (North Grafton MA) Voss Jeffrey W. (Framingham MA), Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters.
    상세보기
  28. Robinson Murray O. (Malibu CA) Hunt Pamela (Thousand Oaks CA) Bosselman Robert A. (Thousand Oaks CA), Transgenic animal models for thrombocytopenia.
    상세보기

이 특허를 인용한 특허 (18)

  1. Gorski, Kevin; Parnes, Jane R.; Bigler, Jeannette; Boedigheimer, Michael J.; Welcher, Andrew A., Assay for detecting Th1 and Th2 cell populations.
    상세보기
  2. Smith, Richard; Bakker, Alice; Duguay, Amy N.; Li, Peng; Li, Yang, Binding proteins that bind to human FGFR1C, human β-klotho and both human FGFR1C and human β-klotho.
    상세보기
  3. Li, Yang; Wu, Xinle; Wang, Zhulun, Chimeric polypeptides and uses thereof.
    상세보기
  4. Belouski, Edward John; Ellison, Murielle Marie; Hamburger, Agnes Eva; Hecht, Randy Ira; Li, Yue-Sheng; Michaels, Mark Leo; Sun, Jeonghoon; Xu, Jing, FGF 21 polypeptides comprising two or more mutations and uses thereof.
    상세보기
  5. Belouski, Edward John; Ellison, Murielle Marie; Hamburger, Agnes Eva; Hecht, Randy Ira; Li, Yue-Sheng; Michaels, Mark Leo; Sun, Jeonghoon; Xu, Jing, FGF mutants with reduced proteolysis and aggregation.
    상세보기
  6. Walker, Kenneth W.; Gegg, Jr., Colin V.; Hecht, Randy I.; Belouski, Edward J.; Li, Yue-Sheng; Michaels, Mark L.; Xu, Jing; Ellison, Murielle M., FGF-21 mutants comprising polyethylene glycol and uses thereof.
    상세보기
  7. Belouski, Edward John; Ellison, Murielle Marie; Hamburger, Agnes Eva; Hecht, Randy Ira; Li, Yue-Sheng; Michaels, Mark Leo; Sun, Jeonghoon; Xu, Jing, FGF21 mutant fusion polypeptides and uses thereof.
    상세보기
  8. Belouski, Edward John; Ellison, Murielle Marie; Hamburger, Agnes Eva; Hecht, Randy Ira; Li, Yue-Sheng; Michaels, Mark Leo; Sun, Jeonghoon; Xu, Jing, FGF21 mutants and uses thereof.
    상세보기
  9. Belouski, Edward John; Ellison, Murielle Marie; Hamburger, Agnes Eva; Hecht, Randy Ira; Li, Yue-Sheng; Michaels, Mark Leo; Sun, Jeonghoon; Xu, Jing, FGF21 mutants and uses thereof.
    상세보기
  10. Belouski, Edward John; Ellison, Murielle Marie; Hamburger, Agnes Eva; Hecht, Randy Ira; Li, Yue-Sheng; Michaels, Mark Leo; Sun, Jeonghoon; Xu, Jing, FGF21 mutants comprising a mutation at position 98, 171 and/or 180.
    상세보기
  11. Belouski, Edward John; Ellison, Murielle Marie; Hamburger, Agnes Eva; Hecht, Randy Ira; Li, Yue-Sheng; Michaels, Mark Leo; Sun, Jeonghoon; Xu, Jing, FGF21 mutants multimers and uses thereof.
    상세보기
  12. Belouski, Edward John; Ellison, Murielle Marie; Hamburger, Agnes Eva; Hecht, Randy Ira; Li, Yue-Sheng; Michaels, Mark Leo; Sun, Jeonghoon; Xu, Jing, FGF21 polypeptides comprising two or more mutations.
    상세보기
  13. Belouski, Edward John; Ellison, Murielle Marie; Hamburger, Agnes Eva; Hecht, Randy Ira; Li, Yue-Sheng; Michaels, Mark Leo; Sun, Jeonghoon; Xu, Jing, FGF21 polypeptides comprising two or more mutations and uses thereof.
    상세보기
  14. Fachini, Roger; Foltz, Ian; Han, Seog Joon; Harris, Susie Miki; Hu, Shaw-Fen Sylvia; King, Chadwick Terence; Li, Yang; Lu, Ji; Michaels, Mark Leo; Sun, Jeonghoon, Human FGF receptor and β-Klotho binding proteins.
    상세보기
  15. Hu, Shaw-Fen Sylvia; Foltz, Ian; King, Chadwick Terence; Li, Yang; Arora, Taruna, Human antigen binding proteins that bind β-Klotho, FGF receptors and complexes thereof.
    상세보기
  16. Hu, Shaw-Fen Sylvia; Foltz, Ian Nevin; King, Chadwick Terence; Li, Yang; Arora, Taruna, Human antigen binding proteins that bind β-klotho, FGF receptors and complexes thereof.
    상세보기
  17. Belouski, Edward John; Ellison, Murielle Marie; Hamburger, Agnes Eva; Hecht, Randy Ira; Li, Yue-Sheng; Michaels, Mark Leo; Sun, Jeonghoon; Xu, Jing, Methods of treating of diabetes and obesity using FGF21 mutants.
    상세보기
  18. Belouski, Edward John; Ellison, Murielle Marie; Hamburger, Agnes Eva; Hecht, Randy Ira; Li, Yue-Sheng; Michaels, Mark Leo; Sun, Jeonghoon; Xu, Jing, Uses of FGF21 polypeptides comprising two or more mutations.
    상세보기

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