이 특허에 인용된 특허 (399)

1. Tkachuk Zenovy (Kiev SUX) Kvasyuk Eugeny (Kiev SUX) Matsuka Gennady (Kiev SUX) Mikhailopulo Igor (Kiev SUX), (2′-5′) oligoadenylate analogues useful as inhibitors of host-v5.-graft response.

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2. De Clercq Erik D. A. (Lovenjoel BEX) Herdewijn Piet A. M. (Rotselaar BEX) Van Aerschot Arthur A. E. (Heist o/d Berg BEX), 1,5-anhydrohexitol nucleoside analogues.

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3. Beigelman, Leonid; Karpeisky, Alex, 2′-O-alkylthioalkyl and 2′-C-alkylthioalkyl-containing nucleic acids.

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4. Buhr Chris A. ; Matteucci Mark, 2' Modified Oligonucleotides.

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5. Chris A. Buhr ; Mark Matteucci, 2' Modified oligonucleotides.

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6. Manoharan Muthiah ; Cook Phillip Dan, 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides.

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7. Manoharan Muthiah ; Kawasaki Andrew M. ; Cook Phillip Dan ; Fraser Allister S. ; Prakash Thazha P., 2'-O-acetamido modified monomers and oligomers.

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8. Beigelman Leonid ; Karpeisky Alex, 2'-O-alkylthioalkyl and 2'-C-alkylthioalkyl-containing nucleic acids.

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9. Beigelman Leonid ; Karpeisky Alex, 2'-O-alkylthioalkyl and 2'-c-alkylthioalkyl-containing nucleic acids.

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10. Beigelman Leonid ; Karpeisky Alex, 2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes).

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11. Cook Phillip Dan ; Manoharan Muthiah ; Kawasaki Andrew Mamoru, 2'-O-aminooxy-modified oligonucleotides.

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12. Cook Phillip Dan ; Guinosso Charles John, 2'-O-modified nucleosides and phosphoramidites.

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13. Cook Phillip Dan ; Kawasaki Andrew Mamoru, 2'-O-modified oligonucleotides.

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14. Cook Phillip Dan ; Kawasaki Andrew Mamoru, 2'-modified oligonucleotides.

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15. Cook Phillip Dan ; Kawasaki Andrew Mamoru, 2'-modified oligonucleotides.

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16. Cook, Phillip Dan; Kawasaki, Andrew Mamoru, 2'modified oligonucleotides.

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17. Huynh Dinh Tam (Croissy/Seine FRX) Gouyette Catherine (Vanves FRX) Igolen Jean (Le Mesnil St. Denis FRX), 2,N⁶-disubstituted and 2,N⁶-trisubstituted adenosine-3′-phosphoramidites.

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18. Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Konstanz DEX), 2,′,5′-phosphorothioate oligoadenylates and plant antiviral uses thereof.

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19. Buhr Chris A. (Daly City CA) Matteucci Mark (Burlingame CA), 2\modified nucleoside and nucleotide compounds.

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20. Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Constance DEX), 2′,5′-phosphorothioate oligoadenylates and their covalent conjugates with polylysine.

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21. Sproat Brian (Heidelberg DEX) Lamond Angus (Wiesenbach DEX), 2′-O-alkylnucleotides as well as polymers which contain such nucleotides.

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22. Usman Nassim (Boulder CO) Karpeisky Alexander (Boulder CO) Beigelman Leonid (Longmont CO) Modak Anil (Boulder CO), 2′-deoxy-2′alkylnucleotide containing nucleic acid.

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23. Montgomery John A. (Birmingham AL) Secrist ; III John A. (Birmingham AL), 2′-deoxy-4′-thioribonucleosides and their antiviral activity.

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24. Usman Nassim (Boulder CO) Karpeisky Alexander (Boulder CO) Beigelman Leonid (Longmont CO) Modak Anil (Boulder CO), 2′deoxy-2′-alkylnucleotide containing nucleic acid.

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25. Cook P. Dan (Carlsbad CA) Acevedo Oscar L. (San Diego CA) Andrews Robert S. (San Juan Capistrano CA), 3-deazapurines.

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26. Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Constance DEX), 3′-deoxy or 3′-O-substituted-2′,5′-oligoadenylates as antiviral agents.

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27. Cook Philip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA), 4′-desmethyl nucleoside analog compounds.

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28. Cook Philip D. (Carlsbad CA) Delecki Daniel J. (Radnor PA) Guinosso Charles (Vista CA), Acyclic nucleoside analogs and oligonucleotide sequences containing them.

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29. Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR) Stirchak Eugene P. (Corvallis OR), Alpha-morpholino ribonucleoside derivatives and polymers thereof.

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30. Bennett C. Frank ; Cooke Stanley T. ; Manoharan Muthiah ; Wyatt Jacqueline R. ; Baker Brenda F. ; Monia Brett P. ; Freier Susan M. ; McKay Robert ; Karras James G., Alteration of cellular behavior by antisense modulation of mRNA processing.

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31. Fung Steven (Palo Alto CA) Woo Sam L. (Redwood City CA) Smith Lloyd M. (South Pasadena CA), Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof.

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32. Agrawal Sudhir (Shrewsbury MA) Tang Jin-Yan (Shrewsbury MA), Aminoalkylphosphorothioamidate oligonucleotide deratives.

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33. Agrawal Sudhir (Shrewsbury MA) Tang Jin-Yan (Shrewsbury MA), Aminoalkylphosphotriester oligonucleotide derivatives.

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34. Manoharan Muthiah ; Cook Phillip Dan ; Prakash Thazha P. ; Kawasaki Andrew M., Aminooxy-modified oligonucleotides and methods for making same.

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35. Lin Kuei-Ying (Fremont CA) Matteucci Mark (Burlingame CA), Anthraquinone-derivatives oligonucleotides.

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36. Monia Brett P. ; Cowsert Lex M., Antisense inhibition of MAP kinase kinase 6 expression.

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37. Monia Brett P. ; Gaarde William ; Ward Donna T. ; Freier Susan M. ; Wyatt Jacqueline, Antisense inhibition of MEKK2 expression.

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38. Monia Brett P. ; Cowsert Lex M. ; McKay Robert, Antisense inhibition of PTEN expression.

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39. Bennett C. Frank ; Dean Nicholas M. ; Monia Brett P. ; Nickoloff Brian J. ; Zhang QingQing, Antisense modulation of BCL-X expression.

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40. Bennett C. Frank ; Condon Thomas P. ; Flournoy Shin Cheng ; Zhang Hong, Antisense modulation of PECAM-1.

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41. C. Frank Bennett ; Lex M. Cowsert, Antisense modulation of calreticulin expression.

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42. Goodnow ; Jr. Robert Alan ; Tam Steve Yik-Kai, Antisense oligomers.

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43. McKay Robert ; Dean Nicholas ; Monia Brett P. ; Nero Pamela S. ; Gaarde William A., Antisense oligonucleotide compositions and methods for the modulation of JNK proteins.

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44. Baracchini Edgardo ; Bennett C. Frank ; Dean Nicholas M., Antisense oligonucleotide modulation of multidrug resistance-associated protein.

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45. Switzer Christopher (Moreno Valley CA), Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides.

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46. McCormick Randy M. (Wilmington DE), Arabinonucleic acid probes for DNA/RNA assays.

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47. Cook Philip D. (Carlsbad CA) Sanghvi Yogesh S. (Carlsbad CA), Backbone modified oligonucleotide analogs.

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48. De Mesmaeker Alain (Kaenerkinden CHX) Lebreton Jacques (Marseilles FRX) Waldner Adrian (Allschwil CHX) Cook Phillip D. (Carlsbad CA), Backbone modified oligonucleotide analogs.

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49. Sanghvi Yogesh S. ; Cook Phillip Dan, Backbone modified oligonucleotide analogs and preparation thereof through radical coupling.

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50. Sanghvi Yogesh S. (Carlsbad CA) Cook Phillip D. (Carlsbad CA), Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling.

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51. Cook Phillip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA) Morvan Francois (Montpellier FRX), Backbone modified oligonucleotide analogs and solid phase synthesis thereof.

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52. Cook Phillip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA) Vasseur Jean J. (San Marcos CA) Debart Francoise (Montpellier FRX), Backbone modified oligonucleotide analogues.

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53. Cook Phillip Dan ; Sanghvi Yogesh Shantilal ; Vasseur Jean Jacques ; Debart Francoise, Backbone modified oligonucleotide analogues.

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54. Sanghvi Yogesh S. (San Marcos CA) Cook Phillip D. (Vista CA), Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling.

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55. Suhadolnik Robert J. ; Pfleiderer Wolfgang,DEX, Base-modified derivatives of 2',5'-oligoadenylate and antiviral uses thereof.

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56. Usman Nassim ; Beigelman Leonid ; McSwiggen James ; Karpeisky Alex, Base-modified enzymatic nucleic acid.

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57. Leumann Christian (Zurich CHX), Bicyclic nucleosides, oligonucleotides, process for their preparation and intermediates.

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58. Leumann Christian (Zurich CHX), Bicyclic nucleosides, oligonucleotides, process for their preparation and intermediates.

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59. Imanishi Takeshi,JPX ; Obika Satoshi,JPX, Bicyclonucleoside and oligonucleotide analogues.

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60. Matteucci Mark D. (Burlingame CA) Cao Xiaodong (Carlsbad CA), Binding compentent oligomers containing unsaturated 3′,5′and 2′,5′linkages.

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61. Tomalia Donald A. ; Baker James R. ; Cheng Roberta C. ; Bielinska Anna U. ; Fazio Michael J. ; Hedstrand David M. ; Johnson Jennifer A. ; Kaplan ; deceased Donald A. ; Klakamp Scott L. ; Kruper ; Jr., Bioactive and/or targeted dendrimer conjugates.

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62. Gref Ruxandra (Nancy FRX) Minamitake Yoshiharu (Brookline MA) Langer Robert S. (Newton MA), Biodegradable injectable nanoparticles.

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63. Spielvogel Bernard F. (Raleigh NC) Sood Anup (Durham NC) Hall Iris H. (Chapel Hill NC) Ramsay Shaw Barbara (Durham NC), Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same.

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64. Spielvogel Bernard F. (107 Wood Glen Dr. Cary NC 27511) Sood Anup (5041 Gatewood Dr. Durham NC 27712), Boronated phosphoramidate compounds.

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65. Hogan James J. (Coronado CA) Arnold ; Jr. Lyle J. (San Diego CA) Nelson Norman C. (San Diego CA) Bezverkov Robert (Cardiff by the Sea CA), Branched nucleic acid probes.

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66. Chung Thomas D. Y. ; Cianci Christopher W. ; Hagen Moira ; Krystal Mark ; Colonno Richard J., Capped nucleic acid oligomers that inhibit cap-dependent transcription of the influenza virus endonuclease.

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67. Cook Phillip Dan ; Manoharan Muthiah, Carbamate-derivatized nucleosides and oligonucleosides.

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68. Cook Phillip Dan ; Manoharan Muthiah, Carbamate-derivatized nucleosides and oligonucleosides.

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69. Altmann Karl-Heinz (Basel CHX) Imwinkelried Rene (Brig-Glis CHX) Eschenmoser Albert (Kusnacht CHX), Carbocyclic nucleosides containing bicyclic rings, oligonucleotides therefrom, process for their preparation, their use.

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70. Altmann Karl-Heinz (Basel CHX) Imwinkelried Rene (Brig-Glis CHX) Eschenmoser Albert (Kusnacht CHX), Carbocyclic nucleosides containing bicyclic rings, oligonucleotides therefrom, process for their preparation, their use.

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71. Manoharan Muthiah, Carbohydrate or 2'-modified oligonucleotides having alternating internucleoside linkages.

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72. Manoharan Muthiah, Carbohydrate or 2'-modified oligonucleotides having alternating internucleoside linkages.

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73. Felgner Philip L. (Rancho Santa Fe CA) Kumar Raj (San Diego CA) Basava Channa (San Diego CA) Border Richard C. (Poway CA) Hwang-Felgner Jiin-Yu (Rancho Santa Fe CA), Cationic lipids for intracellular delivery of biologically active molecules.

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74. Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Constance DEX), Cholesterol conjugates of 2′5′-oligoadenylate derivatives and antiviral uses thereof.

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75. Letsinger Robert L. (Wilmette IL), Cholesteryl modified oligonucleotides.

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76. Magda Darren (Cupertino CA) Sessler Jonathan L. (Austin TX) Iverson Brent (Austin TX), Chromophore probe for detection of nucleic acid.

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77. Bertsch-Frank Birgit (Rheinfelden DEX) Klasen Claas-Juergen (Freigericht DEX) Lieser Thomas (Hapau DEX) Mueller Klaus (Hasselroth DEX) Bewersdorf Martin (Gelnhausen DEX), Coated sodium percarbonate particles, a process for their production and detergent, cleaning and bleaching compositions.

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78. Curiel David T. (Chapel Hill NC) Birnstiel Max L. (Vienna ATX) Cotten Matthew (Vienna ATX) Wagner Ernst (Langenzersdorf ATX) Zatloukal Kurt (Vienna ATX) Plank Christian (Vienna ATX) Oberhauser Berndt, Composition for introducing nucleic acid complexes into higher eucaryotic cells.

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79. Snitman David L. (Boulder CO), Compositions and methods for functionalizing nucleic acids.

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80. Phillip Dan Cook ; Thomas Bruice ; Charles John Guinosso ; Andrew Mamoru Kawasaki ; Richard Griffey, Compositions and methods for modulating RNA.

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81. Teng, Ching-Leou; Hardee, Greg, Compositions and methods for the delivery of oligonucleotides via the alimentary canal.

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82. Stec Wojciech J.,PLX ; Wozniak Lucyna,PLX, Compositions and methods for the synthesis of organophosphorus derivatives.

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83. Cook Phillip D. (Carlsbad CA) Bruice Thomas (Carlsbad CA) Guinosso Charles J. (Carlsbad CA) Kawasaki Andrew M. (Oceanside CA), Compositions for inhibiting RNA activity.

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84. Cook Phillip Dan ; Ecker David J. ; Guinosso Charles John ; Acevedo Oscar Leobardo ; Kawasaki Andrew ; Ramasamy Kandasamy, Compound for detecting and modulating RNA activity and gene expression.

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85. Kmiec Eric B. (Malvern PA), Compounds and methods for site directed mutations in eukaryotic cells.

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86. Ohtsuka Eiko (Sappro JPX) Inoue Hideo (Sappro JPX) Morisawa Hirokazu (Kawasaki JPX) Shibahara Susumu (Kawasaki JPX) Mukai Sachiko (Kawasaki JPX) Nishihara Tohru (Kurashiki JPX), Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and st.

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87. Cook Phillip D. (San Marcos CA) Hoke Glenn (Mt. Airy MD), Compounds having phosphorodithioate linkages of high chiral purity.

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88. Cook Phillip D. (San Marcos CA) Teng Kelly (San Diego CA), Conjugated 4′-desmethyl nucleoside analog compounds.

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89. Dange Veerapanani ; Iwao Nozawa JP, Conjugates and methods of forming conjugates of oligonucleotides and carbohydrates.

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90. Curiel David T. (Chapel Hill NC) Hu Ping-chuan (Chapel Hill NC) Birnstiel Max L. (Vienna ATX) Cotten Matthew (Vienna ATX) Wagner Ernst (Langenzersdorf ATX), Conjugates for introducing nucleic acid into higher eucaryotic cells.

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91. Dellinger Douglas J. (Cardiff by the Sea CA), Copolymers of N-vinyl-lactams suitable for oligomer solid phase synthesis.

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92. Saba Don (Tucson AZ) Glass Richard S. (Tucson AZ) Yabusaki Kenichi K. (Albany CA), Coumarin derivatives for use as nucleotide crosslinking reagents.

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93. Linn C. Preston (Durham NC) Pitner J. Bruce (Durham NC) Mize Pat D. (Durham NC), Covalent cyanine dye oligonucleotide conjugates.

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94. Cook Phillip Dan ; Manoharan Muthiah ; Bruice Thomas, Covalently cross-linked oligonucleotides.

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95. Igor V. Kutyavin ; Eugeny A. Lukhtanov ; Howard B. Gamper ; Rich B. Meyer, Jr., Covalently linked oligonucleotide minor groove binder conjugates.

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96. Cook Phillip D. (Carlsbad CA) Baschang Gerhard (Bettingen CHX), Cyclobutyl oligonucleotide surrogates.

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97. Cook Phillip Dan ; Baschang Gerhard,CHX, Cyclobutyl oligonucleotide surrogates.

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98. Smith Lloyd M. (South Pasadena CA) Fung Steven (Palo Alto CA) Kaiser ; Jr. Robert J. (Glendale CA), DNA-reporter conjugates linked via the 2′or 5′-primary amino group of the 5′-terminal nucleoside.

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99. Nilsen Thor W., Dendritic nucleic acids exhibiting maximal self-assembly.

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100. Smith Lloyd M. (South Pasadena CA) Fung Steven (Palo Alto CA), Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for t.

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101. Usman Nassim ; Wincott Francine E. ; Tracz Danuta, Deprotection of RNA with alkylamine.

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102. Manoharan Muthiah ; Cook Phillip Dan ; Bennett Clarence Frank, Derivatized oligonucleotides having improved uptake and other properties.

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103. Muthiah Manoharan ; Phillip Dan Cook ; Clarence Frank Bennett, Derivatized oligonucleotides having improved uptake and other properties.

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104. Baxter Anthony D. (Northwich GB2) Baylis Eric K. (Stockport GB2) Collingwood Stephen P. (Westhoughton GB2) Taylor Roger J. (Stretford GB2) De Mesmaeker Alain (Kanerkinden CHX) Schmit Chantal (Basel C, Dinucleoside phosphinates and their pharmaceutical compositions.

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105. Tagawa Toshiaki (Yokohama JPX) Hosokawa Saiko (Kawasaki JPX) Nagaike Kazuhiro (Sagamihara JPX), Drug-containing protein-bonded liposome.

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106. Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Konstanz DEX), Dual action 2′,5′-oligoadenylate antiviral derivatives and uses thereof.

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107. Wurster Robert L., Dual ended laser swing aid.

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108. Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Constance DEX), Encapsulated 2′,5′-phosphorothioate oligoadenylates.

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109. Sullivan Sean M. (Pasadena CA), Encapsulation process.

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110. Brakel Christine L. (Brightwaters NY) Cook Alan F. (Cedar Groove NJ) Vuocolo Edmund (Bronx NY), End labeled nucleotide probe.

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111. Froehler Brian (Belmont CA) Matteucci Mark (Burlingame CA), Enhanced triple-helix and double-helix formation with oligomers containing modified purines.

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112. Froehler Brian (Belmont CA) Wagner Rick (Belmont CA) Matteucci Mark (Burlingame CA) Jones Robert J. (Millbrae CA) Gutierrez Arnold J. (Sandy Lane CA) Pudlo Jeff (Burlingame CA), Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines.

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113. Goodchild John, Enhancement of ribozyme catalytic activity by A 2'-O-substituted facilitator oligonucleotide.

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114. Goodchild John (Worcester MA), Enhancement of ribozyme catalytic activity by a neighboring facilitator oligonucleotide.

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115. Uhlmann Eugen,DEX ; Engels Joachim,DEX ; Scherr Michaela,DEX ; Ganser Arnold,DEX, Enzymatic RNA molecules that cleave mutant N-RAS.

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116. Matulic-Adamic Jasenka ; Beigelman Leonid ; Karpeisky Alexander ; Jarvis Thale ; Usman Nassim ; DiRenzo Anthony ; Wincott Francine, Enzymatic nucleic acids containing 5'-and/or 3'-cap structures.

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117. Ingram Lonnie O. (Gainesville FL) Conway Tyrrell (Lincoln NE) Alterthum Flavio (Gainesville FL), Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes.

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118. Weis Alexander L. (Berwyn PA) Oakes Fred T. (Rochester NY) Hausheer Frederick H. (San Antonio TX) Cavanaugh ; Jr. Paul F. (West Chester PA) Moskwa Patricia S. (Phoenixville PA), Exonuclease resistant terminally substituted oligonucleotides.

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119. Froehler Brian C. (Belmont CA), Exonuclease-resistant oligonucleotides.

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120. Brush Charles K. (Whitefish Bay WI), Fluorescein labelled phosphoramidites.

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121. Cook Phillip D. (Vista CA) Monia Brett P. (Carlsbad CA), Gapped 2′modified oligonucleotides.

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122. Fire, Andrew; Kostas, Stephen; Montgomery, Mary; Timmons, Lisa; Xu, SiQun; Tabara, Hiroaki; Driver, Samuel E.; Mello, Craig C., Genetic inhibition by double-stranded RNA.

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123. Bayer Ernst (Bei der Ochsenweide D-7400 Tubingen DEX) Rapp Wolfgang (Stuttgart DEX), Graft copolymers of crosslinked polymers and polyoxyethylene, processes for their production, and their usage.

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124. Manoharan, Muthiah; Cook, Phillip Dan; Prakash, Thazha P.; Mohan, Venkatraman, Guanidinium functionalized nucleotides and precursors thereof.

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125. Manoharan, Muthiah; Cook, Phillip Dan; Prakash, Thazha P.; Mohan, Venkatraman, Guanidinium functionalized oligonucleotides and method/synthesis.

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126. Cook Phillip D. (Carlsbad CA) Sanghvi Yogesh S. (Carlsbad CA), Heteroatomic oligonucleoside linkages.

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127. Cook Phillip Dan ; Sanghvi Yogesh Shantilal, Heteroatomic oligonucleoside linkages.

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128. Teng Kelly (San Diego CA) Sanghvi Yogesh S. (San Marcos CA) Cook Phillip Dan (San Marcos CA), Heteroatomic oligonucleoside linkages.

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129. Schally Andrew V. ; Izdebski Jan, Highly potent agonists of growth hormone releasing hormone.

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130. Metelev Valeri (Shrewsbury MA) Agrawal Sudhir (Shrewsbury MA), Hybrid oligonucleotide phosphorothioates.

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131. Metelev, Valeri; Agrawal, Sudhir, Hybrid oligonucleotide phosphorothioates.

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132. Froehler Brian C. (Belmont CA) Buhr Chris A. (Daly City CA), Hydrogen phosphonodithioate compositions.

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133. Krieg Arthur M. ; Kline Joel ; Klinman Dennis ; Steinberg Alfred D., Immunostimulatory nucleic acid molecules.

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134. Rogers Thomas E. (Manchester MO) Gray Steven H. (Ellisville MO) Devadas Balekudru (Chesterfield MO) Adams Steven P. (St. Charles MO), Improved probes using nucleosides containing 3-dezauracil analogs.

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135. Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke She L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.

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136. Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke She L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.

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137. Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke Shee L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.

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138. Hoffman Allan S. ; Stayton Patrick S., Interactive molecular conjugates.

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139. Coassin Peter J. (San Juan Capistrano CA) Konrad Kenneth D. (Long Beach CA) Rampal Jang B. (Yorba Linda CA) Cook Ronald M. (San Rafael CA), Inverse linkage oligonucleotides for chemical and enzymatic processes.

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140. Agrawal Sudhir (Shrewsbury MA), Inverted chimeric and hybrid oligonucleotides.

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141. Donald L. Wollesen, Junction profiling using a scanning voltage micrograph.

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142. Agrawal Sudhir (Shrewsbury MA) Tang Jin-Yan (Shrewsbury MA), Linear aminoalkylphosphoramidate oligonucleotide derivatives.

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143. Miller Paul S. (Baltimore MD) Ts\O Paul O. P. (Lutherville MD), Linkage of proteins to nucleic acids.

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144. Arnold ; Jr. Lyle J. (San Diego CA) Reynolds Mark A. (San Diego CA) Bhatt Ram S. (San Diego CA), Linking reagents for nucleotide probes.

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145. Zalipsky Samuel (Fremont CA) Woodle Martin C. (Menlo Park CA) Lasic Danilo D. (Newark CA) Martin Francis J. (San Francisco CA), Lipid-polymer conjugates and liposomes.

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146. Louis C. Smith ; James T. Sparrow ; Jochen Hauer ; Martha P. Mims, Lipophilic peptides for macromolecule delivery.

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147. Tari Ana Maria (Houston TX) Lopez-Berestein Gabriel (Houston TX) Deisseroth Albert B. (Houston TX), Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use.

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148. Bally Marcel B. (Bowen Island CAX) Boman Nancy L. (Richmond CAX) Cullis Pieter R. (Vancouver CAX) Mayer Lawrence D. (North Vancouver CAX), Liposomal compositions for enhanced retention of bioactive agents.

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149. Woodle Martin C. (Menlo Park CA) Martin Francis J. (San Francisco CA) Yau-Young Annie (Los Altos CA) Redemann Carl T. (Walnut Creek CA), Liposomes with enhanced circulation time.

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150. Langel Ulo,SEX ; Bartfai Tamas,CHX ; Pooga Margus,EEX ; Valkna Andres,EEX ; Saar Kulliki,SEX ; Hallbrink Mattias,SEX, Membrane-permeable constructs for transport across a lipid membrane.

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151. Thomas H. Adams ; Mark A. Reynolds, Metal complex containing oligonucleoside cleavage compounds and therapies.

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152. Low Philip S. (West Lafayette IN) Horn Mark A. (West Lafayette IN) Heinstein Peter F. (West Lafayette IN), Method for enhanced transmembrane transport of exogenous molecules.

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153. Low Philip S. (West Lafayette IN) Horn Mark A. (West Lafayette IN) Heinstein Peter F. (West Lafayette IN), Method for enhancing transmembrane transport of exogenous molecules.

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154. Benner Steven A. (Hadlaubstrasse 151 CH-8006 Zurich CHX), Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases.

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155. Arnold ; Jr. Lyle J. ; Reynolds Mark A. ; Giachetti Cristina, Method for inhibiting RNA translation using chimeric oligonucleoside compounds.

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156. Kaji Akira (1-9 ; Daimoncho 1-chome Higashikurume-shi ; Tokyo JPX), Method for inhibiting propagation of virus and anti-viral agent.

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157. Matteucci Mark D. (Burlingame CA) Zhang Jiancun (San Francisco CA), Method for oligonucleotide analog synthesis.

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158. Torrence Paul (Silver Spring MD) Silverman Robert (Shaker Heights OH) Maitra Ratan (Euclid OH) Lesiak Krystyna (Gaithersburg MD), Method of cleaving specific strands of RNA and medical treatments thereby.

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159. Agnello Vincent, Method of detecting hepatitis C virus in tissues.

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160. Agrawal Sudhir (Shrewsbury MA) Diasio Robert B. (Birmingham AL) Zhang Ruiwen (Birmingham AL), Method of down-regulating gene expression.

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161. Magda Darren (Cupertino CA) Sessler Jonathan L. (Austin TX) Iverson Brent L. (Austin TX) Sansom Petra I. (Austin TX) Crofts Shaun P. (Campbell CA), Method of expanded porphyrin-oligonucleotide conjugate synthesis.

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162. Irving Edward (Burwell GB2) Banks Christopher P. (Saffron Walden GB2), Method of forming images.

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163. Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.

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164. Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.

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165. Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.

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166. Stec Wojciech J. (Lodz PLX) Uznanski Bogdan (Lodz CA PLX) Bergot B. John (Redwood City CA) Hirschbein Bernard L. (San Francisco CA) Fearon Karen L. (Union City CA), Method of synethesizing sulfurized oligonucleotide analogs.

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167. Benderev Theodore V. (27748 Sommerset La. San Juan Capistrano CA 92675) Naves Neil H. (28852 Woodcreek Mission Viego CA 92692) Legome Mark J. (3255 Driza Mission Viego CA 92692), Method of tensioning a suspended tissue mass.

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168. Woodle Martin C. (Menlo Park CA) Martin Francis J. (San Francisco CA) Huang Shi K. (Castro Valley CA), Method of treatment of inflamed tissues.

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169. Alul Rushdi (Columbia MD), Methods and compositions for sequence-specific hybridization of RNA by 2′-5′oligonucleotides.

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170. Walder Joseph A. (Iowa City IA) Walder Roxanne Y. (Iowa City IA) Eder Paul S. (Iowa City IA) Dagle John M. (Iowa City IA), Methods for blocking the expression of specifically targeted genes.

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171. Gururaja Turuvekere R. (North Andover MA) Adams Darwin P. (Lexington MA) Herrick Benjamin M. (Boxborough MA) Prater David M. (Melrose MA), Methods for controlling sensitivity of electrostrictive transducers.

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174. Cook Phillip Dan (Vista CA) Teng Kelly (San Diego CA), Methods of making conjugated 4′desmethyl nucleoside analog compounds.

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175. Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Methods of preparing gas-filled liposomes.

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176. Froehler Brian ; Wagner Rick ; Matteucci Mark ; Jones Robert J. ; Gutierrez Arnold J. ; Pudlo Jeff, Methods of using oligomers containing modified pyrimidines.

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177. Daily William J. ; Schwartz David Aaron, Methylphosphonate dimer synthesis.

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178. Sundaramoorthi Swaminathan ; Mark Matteucci ; Jeff Pudlo ; Robert J. Jones, Modified internucleoside linkages (II).

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179. Swaminathan Sundaramoorthi ; Matteucci Mark ; Pudlo Jeff ; Jones Robert J., Modified internucleoside linkages (II).

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180. Matteucci Mark (Burlingame CA) Jones Robert J. (Daly City CA) Munger John (San Francisco CA), Modified internucleoside linkages having one nitrogen and two carbon atoms.

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181. Mishra Nrusingha C. (Germantown MD) Khorshidi Hossein S. (Vienna VA) Gan Yuxiang (Bethesda MD) Szweda Pam (Cleveland Heights OH) George Jay (Gaithersburg MD), Modified nucleotides for nucleic acid labeling.

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182. Pieles Uwe (Gttingen DEX) Englisch Uwe (Gttingen DEX) Cramer Friedrich (Gttingen DEX), Modified oligonucleotides.

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183. Sanghvi Yogesh S. ; Cook Phillip Dan, Modified oligonucleotides.

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184. Beaton Graham (Boulder CO) Fisher Eric F. (Boulder CO), Modified oligonucleotides and intermediates useful in nucleic acid therapeutics.

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185. Seela Frank,DEX ; Thomas Horst,DEX, Modified oligonucleotides, their preparation and their use.

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186. Eckstein Fritz (Gottingen DEX) Pieken Wolfgang (Boulder CO) Benseler Fritz (Gleichen/Etzborn DEX) Olsen David B. (West Point PA) Williams David M. (Cambridge GB2) Heidenreich Olaf (Gottingen DEX), Modified ribozymes.

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187. Eckstein Fritz (Gottingen DEX) Pieken Wolfgang (Boulder CO) Benseler Fritz (Gleichen/Etzborn DEX) Olsen David B. (West Point PA) Williams David M. (Cherry Hinton GB2) Heindenreich Olaf (Gottingen DEX, Modified ribozymls.

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188. Martin ; Jr. Thomas J. (Kearny NJ), Modular valve service box.

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189. Chang Tse-wen (Houston TX) deVilliers Jean (Houston TX) Gordon Wayne (Houston TX), Molecular conjugates containing cell membrane-blending agents.

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190. Cook Phillip D. (Carlsbad CA), Monomers for preparation of oligonucleotides having chiral phosphorus linkages.

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191. Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Morpholino-subunit combinatorial library and method.

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192. Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), Multifunctional nucleic acid monomer.

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193. Cook P. Dan (Carlsbad CA) Ramasamy Kanda S. (Laguna Hills CA) Manoharan Muthiah (Carlsbad CA), N-2 substituted purines.

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194. Chang Chu-An (Piedmont CA) Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith.

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195. Chang Chu-An (Piedmont CA) Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith.

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196. Srivastava Suresh C. (Burlington MA) Roy Saroj K. (Waltham MA), N-protected-2′-O-methyl-ribonucleosides and N-protected 2′-O-methyl-3′-cyanoethyl-N-,N-diisopropyl phosphoramidite ri.

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197. Zablocki Jeff A. ; Palle Venkata P. ; Ibrahim Prabha N. ; Belardenelli Luiz, N6 heterocyclic 8-modified adenosine derivatives.

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198. Nelson Paul S. (Union City CA) Kent Mark A. (Sunnyvale CA), Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides.

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199. Lin Kuei-Ying (Fremont CA) Matteucci Mark (Burlingame CA), Non-nucleoside linkers for convenient attachment of labels to oligonucleotides using standard synthetic methods.

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200. Usman, Nassim; Wincott, Francine; Matulic-Adamic, Jasenka; Beigelman, Leonid; Karpeisky, Alex, Non-nucleotide containing RNA.

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201. Usman Nassim ; Wincott Francine ; Matulic-Adamic Jasenka ; Beigelman Leonid ; Karpeisky Alex, Non-nucleotide containing enzymatic nucleic acid.

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202. Usman Nassim ; Wincott Francine ; Matulic-Adamic Jasenka ; Beigelman Leonid ; Karpeisky Alex, Non-nucleotide containing enzymatic nucleic acid.

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203. Shizuya Hiroaki (1632 Indiana Ave. South Pasadena CA 91030) Millar Sharon L. (1825 Lanai St. West Covina CA 91792), Non-radioisotope tagging of fragments.

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204. Ts\o Paul O. P. (2117 Folkstone Rd. Lutherville MD 21093) Miller Paul S. (225 Hopkins Rd. Baltimore MD 21212), Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof.

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205. Tullis Richard H. (Leucadia CA), Novel amphiphilic nucleic acid conjugates.

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206. Nguyen Thanh T. (Tigy FRX) Helene Claude (Saint Cyr en Val FRX) Asseline Ulysse (La Source FRX), Novel compounds containing an oligonucleotide sequence bonded to an intercalating agent, a process for their synthesis a.

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207. Weis Alexander L. (Berwyn PA) Oakes Fred T. (Rochester NY) Hausheer Frederick H. (San Antonio TX) Cavanaugh ; Jr. Paul F. (West Chester PA) Moskwa Patricia S. (Phoenixville PA), Nuclease resistant compounds.

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209. Swaminathan Sundaramoorthi ; Matteucci Mark ; Jones Robert J. ; Pudlo Jeff ; Munger John, Nuclease stable and binding competent oligomers and methods for their use.

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210. Walder Joseph A. (Iowa City IA) Walder Roxanne Y. (Iowa City IA), Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled.

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211. Bischofberger Norbert W. (San Carlos CA) Matteucci Mark D. (Burlingame CA), Nucleic acid intercalating agents.

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212. Thompson, James; Beigelman, Leonid; McSwiggen, James; Karpeisky, Alexander; Bellon, Laurent; Reynolds, Mark; Zwick, Michael; Jarvis, Thale; Woolf, Tod; Haeberli, Peter; Matulic-Adamic, Jasenka, Nucleic acid molecules with novel chemical compositions capable of modulating gene expression.

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213. Ramachandran Kuzhalmannam L. (Natick MA) Cate Richard L. (Plymouth MA), Nucleic acid probe linked to a label having a terminal cysteine.

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214. Rokita Steven E. (Port Jefferson NY) Chatterjee Moneesh (Stony Brook NY), Nucleic acids labeled with naphthoquinone probe.

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215. Buhr Chris (Daly City CA) Matteucci Mark (Burlingame CA) Bischofberger Norbert W. (San Carlos CA) Froehler Brian (Belmont CA), Nucleoside 5′-methylene phosphonates.

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216. Haralambidis Jim (Victoria AUX), Nucleoside derivatives.

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217. Froehler Brian C. (Belmont CA) Buhr Chris A. (Daly City CA), Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues.

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218. Baxter Anthony D. (Northwich GB2) Baylis Eric K. (Stockport GB2) Collingwood Stephen P. (Westhoughton GB2) Taylor Roger J. (Stretford GB2) Mesmaeker Alain (Kanerkinden CHX) Schmit Chantal (Basel CHX), Nucleoside phosphinate compounds and compositions.

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219. Martin Pierre,CHX, Nucleosides and oligonucleotides having 2'-ether groups.

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220. Caruthers Marvin H. (Boulder CO) Matteucci Mark D. (San Francisco CA), Nucleosides useful in the preparation of polynucleotides.

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221. Andrei P. Guzaev ; Phillip Dan Cook ; Muthiah Manoharan ; Balkrishen Bhat, Nucleosidic and non-nucleosidic folate conjugates.

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222. Klevan Leonard (Washington DC) Gebeyehu Gulilat (Silver Spring MD) Rao Prasad Y. (Damascus MD), Nucleotide analogs for nucleic acid labeling and detection.

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223. Imanishi Takeshi,JPX, Nucleotide analogues.

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224. Khan Shaheer H. ; Rosenblum Barnett B. ; Zhen Weiguo ; Menchen Steven M., Nucleotide compounds including a rigid linker.

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225. Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), Nucleotides for introducing selectably cleavable and/or abasic sites into oligonucleotides.

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226. Meyer ; Jr. Rich B. (Woodinville WA) Adams A. David (Snohomish WA) Petrie Charles R. (Woodinville WA), Oligo (aa 상세보기