초록 ▼

An apparatus and method for determining an analyte concentration of a sample, such as a tissue sample. The apparatus may comprise an emitter, close proximity detectors laterally located less than about 2 mm away from the emitter, and far away detectors laterally located greater than about 0.5 cm awa

An apparatus and method for determining an analyte concentration of a sample, such as a tissue sample. The apparatus may comprise an emitter, close proximity detectors laterally located less than about 2 mm away from the emitter, and far away detectors laterally located greater than about 0.5 cm away from the emitter. A plurality of wavelengths may be sent from the emitter to the sample, reflected off of the sample, and received by the detectors. The reflectance value measured by the close proximity detectors may be used to calculate one or more scattering coefficients. The reflectance value measured by the far away detectors may be compared with a reflectance value calculated using the scattering coefficients in a numerical inversion of a diffusion model to determine the analyte concentration of the sample.

대표청구항 ▼

The invention claimed is: 1. A method to determine the concentration of analytes in tissues and samples, the method comprising:a. illuminating a tissue or a sample with a plurality of light wavelengths with one or more light emitters;b. measuring intensity values of light propagated from the tissue

The invention claimed is: 1. A method to determine the concentration of analytes in tissues and samples, the method comprising:a. illuminating a tissue or a sample with a plurality of light wavelengths with one or more light emitters;b. measuring intensity values of light propagated from the tissue or sample at a plurality of distances from the one or more light emitters with at least one detector configured for detecting light, wherein light is measured at a first lateral distance and at a second lateral distance, wherein the first lateral distance is smaller than the second lateral distance;c. calculating one or more scattering coefficients μs′ for the plurality of light wavelengths based on the light intensity values measured at the first lateral distance independent of light intensity values measured at the second lateral distance; andd. calculating analyte concentrations using one or more of the scattering coefficients μs′ and using the intensity values at the plurality of light wavelengths measured at the second lateral distance without calculating scattering coefficients for the plurality of wavelengths based on the light intensity values measured at the second lateral distance.